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WASH complex subunit 4 (WASH complex subunit SWIP)

 WASC4_MOUSE             Reviewed;        1173 AA.
Q3UMB9; Q3TTQ9; Q6ZPZ7; Q8CAK8; Q8CGK0;
03-APR-2007, integrated into UniProtKB/Swiss-Prot.
03-APR-2007, sequence version 2.
28-FEB-2018, entry version 87.
RecName: Full=WASH complex subunit 4 {ECO:0000312|MGI:MGI:2441787};
AltName: Full=WASH complex subunit SWIP {ECO:0000305};
Name=Washc4 {ECO:0000312|MGI:MGI:2441787};
Synonyms=Kiaa1033 {ECO:0000312|MGI:MGI:2441787};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1145 AND 818-1173.
STRAIN=C57BL/6J; TISSUE=Hypothalamus, Mammary gland, and Testis;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-1145.
STRAIN=Czech II; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 124-1173.
TISSUE=Brain;
PubMed=14621295; DOI=10.1093/dnares/10.4.167;
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
Saga Y., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene:
III. The complete nucleotide sequences of 500 mouse KIAA-homologous
cDNAs identified by screening of terminal sequences of cDNA clones
randomly sampled from size-fractionated libraries.";
DNA Res. 10:167-180(2003).
[5]
FUNCTION OF THE WASH COMPLEX.
PubMed=19922875; DOI=10.1016/j.devcel.2009.09.010;
Derivery E., Sousa C., Gautier J.J., Lombard B., Loew D., Gautreau A.;
"The Arp2/3 activator WASH controls the fission of endosomes through a
large multiprotein complex.";
Dev. Cell 17:712-723(2009).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Acts at least in part as component of the WASH core
complex whose assembly at the surface of endosomes seems to
inhibit WASH nucleation-promoting factor (NPF) activity in
recruiting and activating the Arp2/3 complex to induce actin
polymerization, and which is involved in regulation of the fission
of tubules that serve as transport intermediates during endosome
sorting (PubMed:19922875). {ECO:0000250|UniProtKB:Q2M389,
ECO:0000305|PubMed:19922875}.
-!- SUBUNIT: Component of the WASH core complex also described as WASH
regulatory complex (SHRC) composed of WASH (WASHC1, WASH2P or
WASH3P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5.
The WASH core complex associates via WASHC2 with the F-actin-
capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and
CAPZB) in a transient or substoichiometric manner which was
initially described as WASH complex (By similarity).
{ECO:0000250|UniProtKB:Q2M389}.
-!- SUBCELLULAR LOCATION: Early endosome
{ECO:0000250|UniProtKB:Q2M389}.
-!- SIMILARITY: Belongs to the SWIP family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH20314.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=AAH20314.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Sequence=BAE36266.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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EMBL; AC153508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AK038582; BAC30055.1; -; mRNA.
EMBL; AK145000; BAE26179.1; -; mRNA.
EMBL; AK161247; BAE36266.1; ALT_INIT; mRNA.
EMBL; AK166233; BAE38648.1; -; mRNA.
EMBL; BC020314; AAH20314.1; ALT_SEQ; mRNA.
EMBL; AK129269; BAC98079.1; -; mRNA.
CCDS; CCDS36015.1; -.
RefSeq; NP_001028547.2; NM_001033375.2.
UniGene; Mm.491194; -.
ProteinModelPortal; Q3UMB9; -.
BioGrid; 235172; 1.
STRING; 10090.ENSMUSP00000039322; -.
iPTMnet; Q3UMB9; -.
PhosphoSitePlus; Q3UMB9; -.
SwissPalm; Q3UMB9; -.
EPD; Q3UMB9; -.
MaxQB; Q3UMB9; -.
PaxDb; Q3UMB9; -.
PeptideAtlas; Q3UMB9; -.
PRIDE; Q3UMB9; -.
Ensembl; ENSMUST00000038388; ENSMUSP00000039322; ENSMUSG00000034560.
GeneID; 319277; -.
KEGG; mmu:319277; -.
UCSC; uc007gkj.1; mouse.
CTD; 23325; -.
MGI; MGI:2441787; Washc4.
eggNOG; KOG3578; Eukaryota.
eggNOG; ENOG410XRKB; LUCA.
GeneTree; ENSGT00390000002524; -.
HOGENOM; HOG000031074; -.
HOVERGEN; HBG106578; -.
InParanoid; Q3UMB9; -.
KO; K18465; -.
OMA; WFPDNFL; -.
OrthoDB; EOG091G01MK; -.
PhylomeDB; Q3UMB9; -.
TreeFam; TF324604; -.
PRO; PR:Q3UMB9; -.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000034560; -.
CleanEx; MM_A230046K03RIK; -.
ExpressionAtlas; Q3UMB9; baseline and differential.
Genevisible; Q3UMB9; MM.
GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
GO; GO:0005768; C:endosome; IDA:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0071203; C:WASH complex; ISS:UniProtKB.
GO; GO:0016197; P:endosomal transport; IMP:UniProtKB.
GO; GO:0007032; P:endosome organization; ISO:MGI.
GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
InterPro; IPR028283; WASH-7_C.
InterPro; IPR028282; WASH-7_central.
InterPro; IPR028191; WASH-7_N.
InterPro; IPR027307; WASH7.
PANTHER; PTHR31409; PTHR31409; 1.
Pfam; PF14746; WASH-7_C; 1.
Pfam; PF14744; WASH-7_mid; 1.
Pfam; PF14745; WASH-7_N; 1.
1: Evidence at protein level;
Acetylation; Coiled coil; Complete proteome; Endosome; Phosphoprotein;
Protein transport; Reference proteome; Transport.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:Q2M389}.
CHAIN 2 1173 WASH complex subunit 4.
/FTId=PRO_0000282576.
REGION 705 1173 Sufficient for interaction with WASHC5.
{ECO:0000250|UniProtKB:Q2M389}.
COILED 27 56 {ECO:0000255}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:Q2M389}.
MOD_RES 7 7 Phosphoserine.
{ECO:0000250|UniProtKB:Q2M389}.
MOD_RES 1154 1154 Phosphothreonine.
{ECO:0000250|UniProtKB:Q2M389}.
SEQUENCE 1173 AA; 136370 MW; B4473C932FAE26AF CRC64;
MAVDTLSPDW DFDRVDDGSQ KIHAEVQLKN YGRFLEEYTS QLRRIEDALD DLIGDVWDFN
LDPIALKLLP YEQSSLLELI KTENKVLNKV ITVYAALCCE IKKLKYEAET KFYNGLLFYG
EGATDSSMVE GDCQIQMGRF VSFLQELSCF VTRCYEVVMN VIHQLAALYI SNKIGPKIIE
TTGVHFQTMY EHLGELLTVL LTLDEIVDNH VTLKDHWTMY KRLLKSVHHN PSKFGIQEEK
LKPFEKFLLK LEGQLLDGMI FQACIEQQFD SLNGGISVSK NSTFAEEFAH SIRSIFANVE
AKLGEPSEID QRDKYVGICG LFVLHFQIFR TVDKKFYKSL LDICKKVPAI TLTANIIWFP
DNFLIHKMPA AAKLLDRKSL QAIKIHRDTF LQQKAQSLNK DVQSYYVFVS SWMMKMESML
SKEQRMDTFA EDLTNRCNVF IQGFLYAYSI STIIKTTMNL YMSMQKPMTK TSVKALCRLI
ELLKAIEHMF YRRSMVVADS VSHITQHLQH QALSSISVAK KRVISDKKYS EQRLDVLSAL
VLAENTLNGP STKQRRLIVS LALSVGTQMK TFKDEELFPL QVVMKKLDLI SELRERVQAQ
CDCCFLYWHR AVFPIYLDDV YENAVDAARL HYMFSALRDC VPAMMHSRHL ESHELLLDCY
DKEIMDILNE HLLDKLCKEI EKDLRLSVHT HLKLDDRNPF KVGRKDLALF FSLNPIRFFN
RFIDIRAYVT HYLDKTFYNL TTVALHDWAT YSEMRNLATQ RYGLVMTEAH LPSQTLEQGL
DVLEIMRNIH IFVSRYLYNL NNQIFIERTS NNKHLNTINI RHIANSIRTH GTGIMNTTVN
FTYQFLKKKF YIFSQFMYDE HIKSRLIKDI RFFREIKDQN DHKYPFDRAE KFNRGIRKLG
ITPEGQSYLD QFRQLISQIG NAMGYIRMIR SGGLHCSSNA IRFVPDLEDI VSFEELVKEE
GLAEETLRAA RHLDSVLSDH TRNSAEGTEY FKMLVDVFAP EFRRPKNIHL RNFYIIVPPL
TLNFVEHSIS CKEKLNKKNK LGAAFTDDGF AMGVAYTLKL LDQYQEFDSL HWFQSVREKY
IKEIRAVAKQ QNVQSTSQDE KLLQTMNLTQ KRLEVYLQEF ELLYFSLSSA RIFFRADKTA
AEENQEKKEK EEETKTSNGD GPESTVSADP VVK


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