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WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15)

 WDR11_HUMAN             Reviewed;        1224 AA.
Q9BZH6; Q5VWA1; Q9P2J6;
16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
10-OCT-2018, entry version 155.
RecName: Full=WD repeat-containing protein 11;
AltName: Full=Bromodomain and WD repeat-containing protein 2;
AltName: Full=WD repeat-containing protein 15;
Name=WDR11; Synonyms=BRWD2, KIAA1351, WDR15;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND CHROMOSOMAL TRANSLOCATION WITH ZNF320.
PubMed=11536051; DOI=10.1038/sj.onc.1204694;
Chernova O.B., Hunyadi A., Malaj E., Pan H., Crooks C., Roe B.,
Cowell J.K.;
"A novel member of the WD-repeat gene family, WDR11, maps to the 10q26
region and is disrupted by a chromosome translocation in human
glioblastoma cells.";
Oncogene 20:5378-5392(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=10718198; DOI=10.1093/dnares/7.1.65;
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XVI.
The complete sequences of 150 new cDNA clones from brain which code
for large proteins in vitro.";
DNA Res. 7:65-73(2000).
[3]
SEQUENCE REVISION.
PubMed=12168954; DOI=10.1093/dnares/9.3.99;
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
"Construction of expression-ready cDNA clones for KIAA genes: manual
curation of 330 KIAA cDNA clones.";
DNA Res. 9:99-106(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164054; DOI=10.1038/nature02462;
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of
the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[8]
SUBCELLULAR LOCATION, CHROMOSOMAL TRANSLOCATION, INTERACTION WITH
EMX1, VARIANTS HH14 TRP-395; THR-435; GLN-448; GLN-690 AND LEU-1150,
VARIANT GLN-978, AND CHARACTERIZATION OF VARIANTS HH14 TRP-395;
THR-435; GLN-448; GLN-690 AND LEU-1150.
PubMed=20887964; DOI=10.1016/j.ajhg.2010.08.018;
Kim H.G., Ahn J.W., Kurth I., Ullmann R., Kim H.T., Kulharya A.,
Ha K.S., Itokawa Y., Meliciani I., Wenzel W., Lee D., Rosenberger G.,
Ozata M., Bick D.P., Sherins R.J., Nagase T., Tekin M., Kim S.H.,
Kim C.H., Ropers H.H., Gusella J.F., Kalscheuer V., Choi C.Y.,
Layman L.C.;
"WDR11, a WD protein that interacts with transcription factor EMX1, is
mutated in idiopathic hypogonadotropic hypogonadism and Kallmann
syndrome.";
Am. J. Hum. Genet. 87:465-479(2010).
[9]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205 AND SER-209, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[12]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[13]
INTERACTION WITH TBC1D23.
PubMed=29084197; DOI=10.1038/ncb3627;
Shin J.J.H., Gillingham A.K., Begum F., Chadwick J., Munro S.;
"TBC1D23 is a bridging factor for endosomal vesicle capture by golgins
at the trans-Golgi.";
Nat. Cell Biol. 19:1424-1432(2017).
[14]
FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH EMX1 AND GLI3,
VARIANT HH14 LEU-537, AND CHARACTERIZATION OF VARIANTS HH14 TRP-395;
THR-435; GLN-448; LEU-537; GLN-690 AND LEU-1150.
PubMed=29263200; DOI=10.15252/embr.201744632;
Kim Y.J., Osborn D.P., Lee J.Y., Araki M., Araki K., Mohun T.,
Kaensaekoski J., Brandstack N., Kim H.T., Miralles F., Kim C.H.,
Brown N.A., Kim H.G., Martinez-Barbera J.P., Ataliotis P., Raivio T.,
Layman L.C., Kim S.H.;
"WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy
related to Kallmann syndrome.";
EMBO Rep. 19:269-289(2018).
[15]
FUNCTION, SUBCELLULAR LOCATION, AND IDENTIFICATION IN A COMPLEX WITH
FAM91A1 AND C17ORF75.
PubMed=29426865; DOI=10.1038/s41467-018-02919-4;
Navarro Negredo P., Edgar J.R., Manna P.T., Antrobus R.,
Robinson M.S.;
"The WDR11 complex facilitates the tethering of AP-1-derived
vesicles.";
Nat. Commun. 9:596-596(2018).
-!- FUNCTION: Involved in the Hedgehog (Hh) signaling pathway, is
essential for normal ciliogenesis (PubMed:29263200). Regulates the
proteolytic processing of GLI3 and cooperates with the
transcription factor EMX1 in the induction of downstream Hh
pathway gene expression and gonadotropin-releasing hormone
production (PubMed:29263200). WDR11 complex facilitates the
tethering of Adaptor protein-1 complex (AP-1)-derived vesicles.
WDR11 complex acts together with TBC1D23 to facilitate the golgin-
mediated capture of vesicles generated using AP-1
(PubMed:29426865). {ECO:0000269|PubMed:29263200,
ECO:0000269|PubMed:29426865}.
-!- SUBUNIT: Component of the complex WDR11 composed of C17orf75,
FAM91A1 and WDR11; FAM91A1 and WDR11 are required for proper
location of the complex (PubMed:29426865). Interacts (via the N-
terminal and the central portion of the protein) with EMX1
(PubMed:20887964). Interacts with GLI3; the interaction associateS
EMX1 with GLI3 (PubMed:29263200). Interacts with TBC1D23; this
interaction may be indirect and recruits TBC1D23 to AP-1-derived
vesicles (PubMed:29084197, PubMed:29426865).
{ECO:0000269|PubMed:20887964, ECO:0000269|PubMed:29084197,
ECO:0000269|PubMed:29263200, ECO:0000269|PubMed:29426865}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
{ECO:0000269|PubMed:29263200}. Cytoplasm
{ECO:0000269|PubMed:20887964}. Nucleus
{ECO:0000269|PubMed:20887964, ECO:0000269|PubMed:29263200}.
Cytoplasm, cytoskeleton, cilium axoneme
{ECO:0000269|PubMed:29263200}. Cytoplasmic vesicle
{ECO:0000269|PubMed:29426865}. Golgi apparatus, trans-Golgi
network {ECO:0000269|PubMed:29426865}. Note=Shuttles from the
cilium to the nucleus in response to Hh signaling
(PubMed:29263200). Might be shuttling between the nucleus and the
cytoplasm (PubMed:20887964). {ECO:0000269|PubMed:20887964,
ECO:0000269|PubMed:29263200}.
-!- TISSUE SPECIFICITY: Ubiquitous.
-!- DISEASE: Note=A chromosomal aberration involving WDR11 is found in
a form of glioblastoma. Translocation t(10;19)(q26;q13.3) with
ZNF320. {ECO:0000269|PubMed:11536051}.
-!- DISEASE: Note=A chromosomal aberration involving WDR11 is found in
a form of Kallmann syndrome. Translocation
46,XY,t(10;12)(q26.12;q13.11). {ECO:0000269|PubMed:20887964}.
-!- DISEASE: Hypogonadotropic hypogonadism 14 with or without anosmia
(HH14) [MIM:614858]: A disorder characterized by absent or
incomplete sexual maturation by the age of 18 years, in
conjunction with low levels of circulating gonadotropins and
testosterone and no other abnormalities of the hypothalamic-
pituitary axis. In some cases, it is associated with non-
reproductive phenotypes, such as anosmia, cleft palate, and
sensorineural hearing loss. Anosmia or hyposmia is related to the
absence or hypoplasia of the olfactory bulbs and tracts.
Hypogonadism is due to deficiency in gonadotropin-releasing
hormone and probably results from a failure of embryonic migration
of gonadotropin-releasing hormone-synthesizing neurons. In the
presence of anosmia, idiopathic hypogonadotropic hypogonadism is
referred to as Kallmann syndrome, whereas in the presence of a
normal sense of smell, it has been termed normosmic idiopathic
hypogonadotropic hypogonadism (nIHH).
{ECO:0000269|PubMed:20887964, ECO:0000269|PubMed:29263200}.
Note=The disease is caused by mutations affecting the gene
represented in this entry.
-!- SEQUENCE CAUTION:
Sequence=BAA92589.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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EMBL; AF320223; AAK08064.1; -; mRNA.
EMBL; AB037772; BAA92589.2; ALT_INIT; mRNA.
EMBL; AC010998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL391425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC040469; AAH40469.1; -; mRNA.
EMBL; BC071564; AAH71564.1; -; mRNA.
CCDS; CCDS7619.1; -.
RefSeq; NP_060587.8; NM_018117.11.
UniGene; Hs.144447; -.
ProteinModelPortal; Q9BZH6; -.
BioGrid; 120839; 32.
CORUM; Q9BZH6; -.
IntAct; Q9BZH6; 8.
MINT; Q9BZH6; -.
STRING; 9606.ENSP00000263461; -.
iPTMnet; Q9BZH6; -.
PhosphoSitePlus; Q9BZH6; -.
BioMuta; WDR11; -.
DMDM; 17368715; -.
EPD; Q9BZH6; -.
MaxQB; Q9BZH6; -.
PaxDb; Q9BZH6; -.
PeptideAtlas; Q9BZH6; -.
PRIDE; Q9BZH6; -.
ProteomicsDB; 79847; -.
Ensembl; ENST00000263461; ENSP00000263461; ENSG00000120008.
GeneID; 55717; -.
KEGG; hsa:55717; -.
UCSC; uc021pzt.2; human.
CTD; 55717; -.
DisGeNET; 55717; -.
EuPathDB; HostDB:ENSG00000120008.15; -.
GeneCards; WDR11; -.
HGNC; HGNC:13831; WDR11.
HPA; HPA038980; -.
MalaCards; WDR11; -.
MIM; 606417; gene.
MIM; 614858; phenotype.
neXtProt; NX_Q9BZH6; -.
OpenTargets; ENSG00000120008; -.
Orphanet; 478; Kallmann syndrome.
Orphanet; 432; Normosmic congenital hypogonadotropic hypogonadism.
PharmGKB; PA37818; -.
eggNOG; KOG1912; Eukaryota.
eggNOG; ENOG410XT4R; LUCA.
GeneTree; ENSGT00390000004068; -.
HOGENOM; HOG000294084; -.
HOVERGEN; HBG060317; -.
InParanoid; Q9BZH6; -.
OMA; GNDESPI; -.
OrthoDB; EOG091G012S; -.
PhylomeDB; Q9BZH6; -.
TreeFam; TF314830; -.
SignaLink; Q9BZH6; -.
ChiTaRS; WDR11; human.
GeneWiki; BRWD2; -.
GenomeRNAi; 55717; -.
PRO; PR:Q9BZH6; -.
Proteomes; UP000005640; Chromosome 10.
Bgee; ENSG00000120008; Expressed in 222 organ(s), highest expression level in kidney.
CleanEx; HS_BRWD2; -.
ExpressionAtlas; Q9BZH6; baseline and differential.
Genevisible; Q9BZH6; HS.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005765; C:lysosomal membrane; HDA:UniProtKB.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
Gene3D; 2.130.10.10; -; 3.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR036322; WD40_repeat_dom_sf.
SMART; SM00320; WD40; 6.
SUPFAM; SSF50978; SSF50978; 4.
PROSITE; PS00678; WD_REPEATS_1; 3.
1: Evidence at protein level;
Cell projection; Chromosomal rearrangement; Complete proteome;
Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Disease mutation;
Golgi apparatus; Hypogonadotropic hypogonadism; Kallmann syndrome;
Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Repeat;
WD repeat.
CHAIN 1 1224 WD repeat-containing protein 11.
/FTId=PRO_0000050889.
REPEAT 59 108 WD 1.
REPEAT 111 154 WD 2.
REPEAT 354 393 WD 3.
REPEAT 471 510 WD 4.
REPEAT 566 605 WD 5.
REPEAT 708 745 WD 6.
REPEAT 747 787 WD 7.
REPEAT 793 831 WD 8.
REPEAT 893 940 WD 9.
MOD_RES 205 205 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 209 209 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 402 402 Phosphoserine.
{ECO:0000250|UniProtKB:Q8K1X1}.
MOD_RES 406 406 Phosphoserine.
{ECO:0000250|UniProtKB:Q8K1X1}.
VARIANT 395 395 R -> W (in HH14; does not affect the
interaction with EMX1; does not affect
the subcellular location of the protein;
decreases capacity to shuttle from cilium
to nucleus; decreases GLI3 protein
levels; dbSNP:rs201051480).
{ECO:0000269|PubMed:20887964,
ECO:0000269|PubMed:29263200}.
/FTId=VAR_069194.
VARIANT 435 435 A -> T (in HH14; abolishes the
interaction with EMX1; does not affect
the subcellular location of the protein;
decreases capacity to shuttle from cilium
to nucleus; decreases interaction with
EMX1; decreases GLI3 protein levels;
dbSNP:rs318240760).
{ECO:0000269|PubMed:20887964,
ECO:0000269|PubMed:29263200}.
/FTId=VAR_069195.
VARIANT 448 448 R -> Q (in HH14; reduces the interaction
with EMX1; does not affect the
subcellular location of the protein;
decreases capacity to shuttle from cilium
to nucleus; decreases GLI3 protein
levels; dbSNP:rs144440500).
{ECO:0000269|PubMed:20887964,
ECO:0000269|PubMed:29263200}.
/FTId=VAR_069196.
VARIANT 537 537 P -> L (in HH14; mild phenotype;
decreases capacity to shuttle from cilium
to nucleus; decreases interaction with
EMX1; no effect on GLI3 protein levels).
{ECO:0000269|PubMed:29263200}.
/FTId=VAR_080856.
VARIANT 690 690 H -> Q (in HH14; abolishes the
interaction with EMX1; decreases capacity
to shuttle from cilium to nucleus;
decreases interaction with EMX1;
decreases GLI3 protein levels;
dbSNP:rs318240761).
{ECO:0000269|PubMed:20887964,
ECO:0000269|PubMed:29263200}.
/FTId=VAR_069197.
VARIANT 978 978 K -> Q (in dbSNP:rs144531702).
{ECO:0000269|PubMed:20887964}.
/FTId=VAR_069198.
VARIANT 1150 1150 F -> L (in HH14; does not affect the
subcellular location of the protein;
decreases capacity to shuttle from cilium
to nucleus; decreases GLI3 protein
levels; dbSNP:rs139007744).
{ECO:0000269|PubMed:20887964,
ECO:0000269|PubMed:29263200}.
/FTId=VAR_069199.
SEQUENCE 1224 AA; 136685 MW; 918221ABEAEFB4ED CRC64;
MLPYTVNFKV SARTLTGALN AHNKAAVDWG WQGLIAYGCH SLVVVIDSIT AQTLQVLEKH
KADVVKVKWA RENYHHNIGS PYCLRLASAD VNGKIIVWDV AAGVAQCEIQ EHAKPIQDVQ
WLWNQDASRD LLLAIHPPNY IVLWNADTGT KLWKKSYADN ILSFSFDPFD PSHLTLLTSE
GIVFISDFSP SKPPSGPGKK VYISSPHSSP AHNKLATATG AKKALNKVKI LITQEKPSAE
FITLNDCLQL AYLPSKRNHM LLLYPREILI LDLEVNQTVG VIAIERTGVP FLQVIPCFQR
DGLFCLHENG CITLRVRRSY NNIFTTSNEE PDPDPVQELT YDLRSQCDAI RVTKTVRPFS
MVCCPVNENA AALVVSDGRV MIWELKSAVC NRNSRNSSSG VSPLYSPVSF CGIPVGVLQN
KLPDLSLDNM IGQSAIAGEE HPRGSILREV HLKFLLTGLL SGLPAPQFAI RMCPPLTTKN
IKMYQPLLAV GTSNGSVLVY HLTSGLLHKE LSIHSCEVKG IEWTSLTSFL SFATSTPNNM
GLVRNELQLV DLPTGRSIAF RGERGNDESA IEMIKVSHLK QYLAVVFRDK PLELWDVRTC
TLLREMSKNF PTITALEWSP SHNLKSLRKK QLATREAMAR QTVVSDTELS IVESSVISLL
QEAESKSELS QNISAREHFV FTDIDGQVYH LTVEGNSVKD SARIPPDGSM GSITCIAWKG
DTLVLGDMDG NLNFWDLKGR VSRGIPTHRS WVRKIRFAPG KGNQKLIAMY NDGAEVWDTK
EVQMVSSLRS GRNVTFRILD VDWCTSDKVI LASDDGCIRV LEMSMKSACF RMDEQELTEP
VWCPYLLVPR ASLALKAFLL HQPWNGQYSL DISHVDYPEN EEIKNLLQEQ LNSLSNDIKK
LLLDPEFTLL QRCLLVSRLY GDESELHFWT VAAHYLHSLS QEKSASTTAP KEAAPRDKLS
NPLDICYDVL CENAYFQKFQ LERVNLQEVK RSTYDHTRKC TDQLLLLGQT DRAVQLLLET
SADNQHYYCD SLKACLVTTV TSSGPSQSTI KLVATNMIAN GKLAEGVQLL CLIDKAADAC
RYLQTYGEWN RAAWLAKVRL NPEECADVLR RWVDHLCSPQ VNQKSKALLV LLSLGCFFSV
AETLHSMRYF DRAALFVEAC LKYGAFEVTE DTEKLITAIY ADYARSLKNL GFKQGAVLFA
SKAGAAGKDL LNELESPKEE PIEE


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EIAAB44425 DCRR1,E3 ubiquitin-protein ligase TTC3,Homo sapiens,Human,Protein DCRR1,RING finger protein 105,RNF105,Tetratricopeptide repeat protein 3,TPR repeat protein 3,TPR repeat protein D,TPRD,TTC3
EIAAB14616 FBL3A,F-box and leucine-rich repeat protein 3A,F-box_LRR-repeat protein 3,F-box_LRR-repeat protein 3A,FBXL3,FBXL3A,Homo sapiens,Human
EIAAB46274 Homo sapiens,Human,PQQ repeat and WD repeat-containing protein,PQWD,WD repeat-containing protein 88,WDR88
EIAAB46450 Homo sapiens,Human,WD repeat-containing protein 8,WD repeat-containing protein antisense to TP73 gene,WD repeat-containing protein WRAP73,WDR8,WRAP73
EIAAB46451 Dd57,Mouse,Mus musculus,WD repeat-containing protein 8,WD repeat-containing protein antisense to TP73 gene,WD repeat-containing protein WRAP73,Wdr8,Wrap73
EIAAB46368 DXImx38e,Mouse,Mus musculus,WD repeat domain phosphoinositide-interacting protein 4,WD repeat domain X-linked 1,WD repeat-containing protein 45,Wdr45,Wdrx1,Wipi4,WIPI-4
EIAAB44365 Kiaa1992,Mouse,Mus musculus,Tetratricopeptide repeat protein 21B,Tetratricopeptide repeat-containing hedgehog modulator 1,Thm1,TPR repeat protein 21B,Ttc21b
EIAAB44363 Mouse,Mus musculus,Tetratricopeptide repeat protein 21A,Tetratricopeptide repeat-containing hedgehog modulator 2,Thm2,TPR repeat protein 21A,Ttc21a
EIAAB46365 Homo sapiens,Human,WD repeat domain phosphoinositide-interacting protein 3,WD repeat-containing protein 45-like,WDR45L,WDR45-like protein,WIPI3,WIPI-3,WIPI49-like protein
EIAAB14621 FBL4,FBL5,F-box and leucine-rich repeat protein 5,F-box protein FBL4_FBL5,F-box_LRR-repeat protein 5,FBXL5,FLR1,Homo sapiens,Human,p45SKP2-like protein
EIAAB44421 Homo sapiens,Human,Protein TBPP2A,Testis development protein NYD-SP14,Tetratricopeptide repeat protein 29,TPR repeat protein 29,TTC29
EIAAB43358 CAG repeat protein 26,CAGH26,EMSY interactor protein,Glycine-tryptophan protein of 182 kDa,GW182 autoantigen,Homo sapiens,Human,KIAA1460,Protein GW1,TNRC6,TNRC6A,Trinucleotide repeat-containing gene 6
EIAAB44455 Bardet-Biedl syndrome 8 protein,BBS8,Homo sapiens,Human,Tetratricopeptide repeat protein 8,TPR repeat protein 8,TTC8
EIAAB43516 Mouse,Mus musculus,Tetratricopeptide repeat protein 15,TPR repeat protein 15,Trafficking protein particle complex subunit 12,Trappc12,Ttc15
EIAAB44456 Bardet-Biedl syndrome 8 protein homolog,Bbs8,Mouse,Mus musculus,Tetratricopeptide repeat protein 8,TPR repeat protein 8,Ttc8
EIAAB46364 Mouse,Mus musculus,WD repeat domain phosphoinositide-interacting protein 3,WD repeat-containing protein 45-like,Wdr45l,WDR45-like protein,Wipi3,WIPI-3
EIAAB14613 FBL2,FBL3,F-box and leucine-rich repeat protein 2,F-box protein FBL2_FBL3,F-box_LRR-repeat protein 2,FBXL2,Homo sapiens,Human
EIAAB43515 CGI-87,Homo sapiens,Human,Tetratricopeptide repeat protein 15,TPR repeat protein 15,Trafficking protein particle complex subunit 12,TRAPPC12,TTC15
EIAAB14617 FBL4,FBL5,F-box and leucine-rich repeat protein 4,F-box protein FBL4_FBL5,F-box_LRR-repeat protein 4,FBXL4,Homo sapiens,Human
EIAAB44406 Cervical cancer proto-oncogene 8 protein,HCC8,HCC-8,Homo sapiens,Human,Tetratricopeptide repeat protein 23,TPR repeat protein 23,TTC23


 

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