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WD repeat-containing protein 35 (Naofen)

 WDR35_RAT               Reviewed;        1170 AA.
A6N6J5;
08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
24-JUL-2007, sequence version 1.
28-MAR-2018, entry version 83.
RecName: Full=WD repeat-containing protein 35;
AltName: Full=Naofen;
Name=Wdr35;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
STRAIN=Wistar;
PubMed=20193664; DOI=10.1016/j.bbrc.2010.02.133;
Feng G.G., Li C., Huang L., Tsunekawa K., Sato Y., Fujiwara Y.,
Komatsu T., Honda T., Fan J.H., Goto H., Koide T., Hasegawa T.,
Ishikawa N.;
"Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor
necrosis factor-induced apoptosis.";
Biochem. Biophys. Res. Commun. 394:153-157(2010).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Component of the IFT complex A (IFT-A), a complex
required for retrograde ciliary transport. Required for
ciliogenesis. May promote CASP3 activation and TNF-stimulated
apoptosis (By similarity). {ECO:0000250,
ECO:0000269|PubMed:20193664}.
-!- SUBUNIT: Component of the IFT complex A (IFT-A). Interacts with
IFT43 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule
organizing center, centrosome {ECO:0000250}. Cytoplasm,
cytoskeleton, cilium axoneme {ECO:0000250}. Cytoplasm,
cytoskeleton, cilium basal body {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed at high levels in testis and at
lower levels in the brain (at protein level). Also present in
other tissues, including heart, uterus, spinal cord, ovary, liver,
kidney, lung, pancreas and stomach. {ECO:0000269|PubMed:20193664}.
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EMBL; EF613262; ABR22620.1; -; mRNA.
EMBL; CH473947; EDM03084.1; -; Genomic_DNA.
RefSeq; NP_001092810.1; NM_001099340.1.
UniGene; Rn.14574; -.
ProteinModelPortal; A6N6J5; -.
STRING; 10116.ENSRNOP00000042019; -.
PaxDb; A6N6J5; -.
PeptideAtlas; A6N6J5; -.
PRIDE; A6N6J5; -.
Ensembl; ENSRNOT00000051970; ENSRNOP00000042019; ENSRNOG00000028783.
GeneID; 503018; -.
KEGG; rno:503018; -.
CTD; 57539; -.
RGD; 1564116; Wdr35.
eggNOG; KOG2041; Eukaryota.
eggNOG; ENOG410XNSQ; LUCA.
GeneTree; ENSGT00610000085970; -.
HOGENOM; HOG000255527; -.
HOVERGEN; HBG079343; -.
InParanoid; A6N6J5; -.
KO; K19674; -.
OMA; QYYVQGR; -.
OrthoDB; EOG091G014X; -.
PhylomeDB; A6N6J5; -.
Reactome; R-RNO-5610787; Hedgehog 'off' state.
Reactome; R-RNO-5620924; Intraflagellar transport.
PRO; PR:A6N6J5; -.
Proteomes; UP000002494; Chromosome 6.
Bgee; ENSRNOG00000028783; -.
Genevisible; A6N6J5; RN.
GO; GO:0005930; C:axoneme; ISS:UniProtKB.
GO; GO:0005813; C:centrosome; ISS:UniProtKB.
GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
GO; GO:0005929; C:cilium; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0030991; C:intraciliary transport particle A; ISS:UniProtKB.
GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
GO; GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
GO; GO:1990830; P:cellular response to leukemia inhibitory factor; ISO:RGD.
GO; GO:1905705; P:cellular response to paclitaxel; IEP:RGD.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IMP:RGD.
GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
GO; GO:0035721; P:intraciliary retrograde transport; ISO:RGD.
GO; GO:0097421; P:liver regeneration; IEP:RGD.
GO; GO:0097756; P:negative regulation of blood vessel diameter; IDA:RGD.
GO; GO:0010629; P:negative regulation of gene expression; IDA:RGD.
GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IDA:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:RGD.
GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:RGD.
GO; GO:0061512; P:protein localization to cilium; IBA:GO_Central.
GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
GO; GO:1901555; P:response to paclitaxel; IEP:RGD.
GO; GO:0009636; P:response to toxic substance; IEP:RGD.
Gene3D; 1.25.40.10; -; 1.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR024977; Apc4_WD40_dom.
InterPro; IPR011990; TPR-like_helical_dom_sf.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
InterPro; IPR017233; WDR35.
PANTHER; PTHR16517:SF1; PTHR16517:SF1; 1.
Pfam; PF12894; ANAPC4_WD40; 1.
PIRSF; PIRSF037536; WD_repeat_p35; 1.
SMART; SM00320; WD40; 4.
SUPFAM; SSF50978; SSF50978; 2.
PROSITE; PS50082; WD_REPEATS_2; 1.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
1: Evidence at protein level;
Cell projection; Cilium; Cilium biogenesis/degradation;
Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome;
Repeat; WD repeat.
CHAIN 1 1170 WD repeat-containing protein 35.
/FTId=PRO_0000405406.
REPEAT 12 51 WD 1.
REPEAT 69 108 WD 2.
REPEAT 113 152 WD 3.
REPEAT 154 193 WD 4.
REPEAT 491 528 WD 5.
SEQUENCE 1170 AA; 132779 MW; 70792ECD36111DEF CRC64;
MFFYLSKKIA VPNNVKLKCI SWNKDQGFIA CGGEDGLLKV LRLETQTDDS KLRGLAAPSN
LSMNQNLEGH SGAVQVVTWN EQYQKLTTSD QNGLIIVWML YKGSWYEEMI NNRNKSVVRS
MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKDLKGIQLC HVTWSADSKI LLFGMANGEI
HIYDNQGNFI MKMKLNCLVN VTGAISIAGI HWYHGTEGYV EPDCPCLAIC FDNGRCQIMR
HENDQNPVLI DTGMYVVGIQ WNHIGSVLAV AGSQKVVTQD KDVNIVQFYT PFGEHLGTLK
VPGKQMCSLS WEGGGLKIAL AVDSFIYFAN IRPDYKWGYC SNTVVYAYTR PDRPEYCVVF
WDTKNNEKYV KYVKSLISIT TCGDFCILAT KADENHPQFV LVLCNSIGTP LDPKYIDLVP
LFVAMTKTHV IAASKEALYT WQYRVAKKLT ALEINQITRS RKEGRERIYH VDDVPSGSVD
GVFDYSKAIQ GTRDPICAIT ASDKTLIVGR ESGVIQRYSF PNVALIQKYS LDCRACQLSL
NCNSSRLAII DIAGVLTFFD LDTRVTDSTG QQVVGELLKL ERKDVWDMKW AKDNPDLFAM
MEKTRMYVFR NLDPEEPIQT SGYICNFEDL EIKSVLLDEI LKNPEHPSKD YIMNFEIRSL
RDSRALIEKV GIEDASQFIE DNPHPRLWRL LAEAALQKLD LYTAQQAFVR CKDYQGIKFV
KRLGNLQSES MKQAEVIAYF GRFEEAERMY LDMDRRDLAI GLRLKLGDWF RVLQLLKTGS
GDADDSLLEQ AHNAIGDYFA DRQKWMNAVQ YYVKGRNQER LAECYYMLED YEGLENLANS
LPENHKLLPE IAQMFVRVGM CEQAVSAFLK CNQPKAAVDT CVHLNQWNKA VELAKSHSMK
EIGSLLARYA SHLLEKNKTL DAIELYRKAS YFFDAAKLMY KIADEEAKKR TKPLRVKKLY
VLSALLIEQY HEQMKNAQRG KVKGKNSEAT SALAGLLEEE VLSTTSRFTD NAWRGAEAYH
FFILAQRQLY EGYVDTALKT ALHLRDYEDI IPSVEIYSLL ALCACASRAF GTCSKAFIKL
ESLETLSAEQ KQQYEDLALE IFTKHTPKDN RKSELNSLLE GGEGKLPTCI ATGSPIIEYQ
FWVCKVCKHY VLAQEISNYN FCPLCHSSVE


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