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WT1( KTS) protein

 Q9I8A0_CHICK            Unreviewed;       417 AA.
Q9I8A0;
01-OCT-2000, integrated into UniProtKB/TrEMBL.
01-OCT-2000, sequence version 1.
05-JUL-2017, entry version 112.
SubName: Full=WT1(+KTS) protein {ECO:0000313|EMBL:BAA94794.1};
Name=WT1(+KTS) {ECO:0000313|EMBL:BAA94794.1};
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031 {ECO:0000313|EMBL:BAA94794.1};
[1] {ECO:0000313|EMBL:BAA94794.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Ovary {ECO:0000313|EMBL:BAA94794.1};
Kudo T.;
"Chicken counterpart of Wilms' tumor suppressor gene 1.";
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
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EMBL; AB033634; BAA94794.1; -; mRNA.
RefSeq; NP_990547.1; NM_205216.1.
UniGene; Gga.42868; -.
ProteinModelPortal; Q9I8A0; -.
PaxDb; Q9I8A0; -.
GeneID; 101747322; -.
KEGG; gga:101747322; -.
CTD; 7490; -.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
HOGENOM; HOG000230937; -.
HOVERGEN; HBG006960; -.
KO; K09234; -.
PhylomeDB; Q9I8A0; -.
GO; GO:0005737; C:cytoplasm; ISA:AgBase.
GO; GO:0016607; C:nuclear speck; ISA:AgBase.
GO; GO:0005654; C:nucleoplasm; ISA:AgBase.
GO; GO:0005634; C:nucleus; IDA:AgBase.
GO; GO:0070742; F:C2H2 zinc finger domain binding; ISA:AgBase.
GO; GO:0003690; F:double-stranded DNA binding; ISA:AgBase.
GO; GO:0010385; F:double-stranded methylated DNA binding; ISS:AgBase.
GO; GO:0044729; F:hemi-methylated DNA-binding; ISS:AgBase.
GO; GO:0003723; F:RNA binding; ISA:AgBase.
GO; GO:0043565; F:sequence-specific DNA binding; ISA:AgBase.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISA:AgBase.
GO; GO:0044212; F:transcription regulatory region DNA binding; ISA:AgBase.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; ISA:AgBase.
GO; GO:0008270; F:zinc ion binding; ISA:AgBase.
GO; GO:0035802; P:adrenal cortex formation; ISA:AgBase.
GO; GO:0030325; P:adrenal gland development; ISA:AgBase.
GO; GO:0006915; P:apoptotic process; ISA:AgBase.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISA:AgBase.
GO; GO:0043010; P:camera-type eye development; ISA:AgBase.
GO; GO:0060923; P:cardiac muscle cell fate commitment; ISA:AgBase.
GO; GO:0071320; P:cellular response to cAMP; ISA:AgBase.
GO; GO:0071371; P:cellular response to gonadotropin stimulus; ISA:AgBase.
GO; GO:0043009; P:chordate embryonic development; IEP:AgBase.
GO; GO:0030855; P:epithelial cell differentiation; ISA:AgBase.
GO; GO:0030317; P:flagellated sperm motility; ISA:AgBase.
GO; GO:0007281; P:germ cell development; ISA:AgBase.
GO; GO:0032836; P:glomerular basement membrane development; ISA:AgBase.
GO; GO:0072015; P:glomerular visceral epithelial cell development; ISA:AgBase.
GO; GO:0072112; P:glomerular visceral epithelial cell differentiation; ISA:AgBase.
GO; GO:0032835; P:glomerulus development; ISA:AgBase.
GO; GO:0008406; P:gonad development; ISA:AgBase.
GO; GO:0007507; P:heart development; ISA:AgBase.
GO; GO:0001822; P:kidney development; ISA:AgBase.
GO; GO:0060993; P:kidney morphogenesis; NAS:AgBase.
GO; GO:0030539; P:male genitalia development; ISA:AgBase.
GO; GO:0008584; P:male gonad development; ISA:AgBase.
GO; GO:0060231; P:mesenchymal to epithelial transition; ISA:AgBase.
GO; GO:0001823; P:mesonephros development; ISA:AgBase.
GO; GO:0072278; P:metanephric comma-shaped body morphogenesis; ISA:AgBase.
GO; GO:0072207; P:metanephric epithelium development; ISA:AgBase.
GO; GO:0072075; P:metanephric mesenchyme development; ISA:AgBase.
GO; GO:0072284; P:metanephric S-shaped body morphogenesis; ISA:AgBase.
GO; GO:0001656; P:metanephros development; ISA:AgBase.
GO; GO:0043066; P:negative regulation of apoptotic process; ISA:AgBase.
GO; GO:0045596; P:negative regulation of cell differentiation; NAS:AgBase.
GO; GO:0030308; P:negative regulation of cell growth; ISA:AgBase.
GO; GO:0008285; P:negative regulation of cell proliferation; ISA:AgBase.
GO; GO:2000195; P:negative regulation of female gonad development; ISA:AgBase.
GO; GO:1900212; P:negative regulation of mesenchymal cell apoptotic process involved in metanephros development; ISA:AgBase.
GO; GO:0072302; P:negative regulation of metanephric glomerular mesangial cell proliferation; ISA:AgBase.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISA:AgBase.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISA:AgBase.
GO; GO:0017148; P:negative regulation of translation; ISA:AgBase.
GO; GO:0043065; P:positive regulation of apoptotic process; ISS:AgBase.
GO; GO:0060421; P:positive regulation of heart growth; ISA:AgBase.
GO; GO:2000020; P:positive regulation of male gonad development; ISA:AgBase.
GO; GO:2001076; P:positive regulation of metanephric ureteric bud development; ISA:AgBase.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISA:AgBase.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISA:AgBase.
GO; GO:0072166; P:posterior mesonephric tubule development; ISA:AgBase.
GO; GO:0003156; P:regulation of animal organ formation; ISA:AgBase.
GO; GO:0010468; P:regulation of gene expression; ISA:AgBase.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISA:AgBase.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISA:AgBase.
GO; GO:0008380; P:RNA splicing; ISA:AgBase.
GO; GO:0072520; P:seminiferous tubule development; ISA:AgBase.
GO; GO:0060009; P:Sertoli cell development; ISA:AgBase.
GO; GO:0007530; P:sex determination; ISA:AgBase.
GO; GO:0007338; P:single fertilization; ISA:AgBase.
GO; GO:0007283; P:spermatogenesis; ISA:AgBase.
GO; GO:0007356; P:thorax and anterior abdomen determination; ISA:AgBase.
GO; GO:0009888; P:tissue development; ISA:AgBase.
GO; GO:0006366; P:transcription from RNA polymerase II promoter; ISA:AgBase.
GO; GO:0001657; P:ureteric bud development; ISA:AgBase.
GO; GO:0001570; P:vasculogenesis; ISA:AgBase.
GO; GO:0061032; P:visceral serous pericardium development; ISA:AgBase.
InterPro; IPR017987; Wilms_tumour.
InterPro; IPR000976; Wilms_tumour_N.
InterPro; IPR013087; Znf_C2H2_type.
Pfam; PF02165; WT1; 1.
PRINTS; PR00049; WILMSTUMOUR.
SMART; SM00355; ZnF_C2H2; 4.
SUPFAM; SSF57667; SSF57667; 2.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
2: Evidence at transcript level;
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
DOMAIN 291 320 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 321 350 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 351 378 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 382 411 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
SEQUENCE 417 AA; 46958 MW; 47BBF7F6448E7F6C CRC64;
MGSDVRDLNA LLPSVPSLPG NSNCAMPVSS AAQWAPVLDF PPGASYGSLG PHSFIKQEPS
WNGSDPHEEQ YLSAFTVHFS GQFTGTAGAC RYGPFGAPPP SQPPSGQARM FPQRPYLPNC
LESQQAIRNQ GYGTVAFDGT PSYGHTPSHH AAQFQNHSFK HEDPMSQQPS LGDQQYSVPP
PVYGCHTPTD TCTGSQALLL RTPYNSDNLY QMTSRLECMT WNQMNLGSTL KGHTTGYENE
NHSAPMLYSC GAQYRIHTHG VFRGIQDVRR VPGVAPTIVR SASETNEKRP FMCAYPGCNK
RYFKLSHLQM HSRKHTGEKP YQCDFKDCER RFSRSDQLKR HQRRHTGVKP FQCKTCQRKF
SRSDHLKTHT RTHTGKTSEK PFSCRWPSCQ KKFARSDELV RHHNMHQRNM TKLQLAL


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