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Wilms tumor 1-KTS isoform

 A9CSE8_RUGRU            Unreviewed;       413 AA.
A9CSE8;
05-FEB-2008, integrated into UniProtKB/TrEMBL.
05-FEB-2008, sequence version 1.
07-JUN-2017, entry version 37.
SubName: Full=Wilms tumor 1-KTS isoform {ECO:0000313|EMBL:BAF95704.1};
Name=WT1 -KTS isoform {ECO:0000313|EMBL:BAF95704.1};
Rugosa rugosa (Japanese wrinkled frog) (Glandirana rugosa).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rugosa.
NCBI_TaxID=8410 {ECO:0000313|EMBL:BAF95704.1};
[1] {ECO:0000313|EMBL:BAF95704.1}
NUCLEOTIDE SEQUENCE.
PubMed=16219985; DOI=10.2108/zsj.22.1045;
Yamamura Y., Aoyama S., Oshima Y., Kato T., Osawa N., Nakamura M.;
"Molecular cloning and expression in gonad of Rana rugosa WT1 and
Fgf9.";
Zool. Sci. 22:1045-1050(2005).
[2] {ECO:0000313|EMBL:BAF95704.1}
NUCLEOTIDE SEQUENCE.
Yamamura Y., Nakamura M.;
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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EMBL; AB372106; BAF95704.1; -; mRNA.
ProteinModelPortal; A9CSE8; -.
HOVERGEN; HBG006960; -.
GO; GO:0005737; C:cytoplasm; ISA:AgBase.
GO; GO:0016607; C:nuclear speck; ISA:AgBase.
GO; GO:0005654; C:nucleoplasm; ISA:AgBase.
GO; GO:0005634; C:nucleus; ISA:AgBase.
GO; GO:0070742; F:C2H2 zinc finger domain binding; ISA:AgBase.
GO; GO:0003690; F:double-stranded DNA binding; ISA:AgBase.
GO; GO:0010385; F:double-stranded methylated DNA binding; ISS:AgBase.
GO; GO:0044729; F:hemi-methylated DNA-binding; ISS:AgBase.
GO; GO:0003723; F:RNA binding; ISA:AgBase.
GO; GO:0043565; F:sequence-specific DNA binding; ISA:AgBase.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISA:AgBase.
GO; GO:0044212; F:transcription regulatory region DNA binding; ISA:AgBase.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; ISA:AgBase.
GO; GO:0008270; F:zinc ion binding; ISA:AgBase.
GO; GO:0035802; P:adrenal cortex formation; ISA:AgBase.
GO; GO:0030325; P:adrenal gland development; ISA:AgBase.
GO; GO:0006915; P:apoptotic process; ISA:AgBase.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISA:AgBase.
GO; GO:0043010; P:camera-type eye development; ISA:AgBase.
GO; GO:0060923; P:cardiac muscle cell fate commitment; ISA:AgBase.
GO; GO:0071320; P:cellular response to cAMP; ISA:AgBase.
GO; GO:0071371; P:cellular response to gonadotropin stimulus; ISA:AgBase.
GO; GO:0060539; P:diaphragm development; ISA:AgBase.
GO; GO:0030855; P:epithelial cell differentiation; ISA:AgBase.
GO; GO:0030317; P:flagellated sperm motility; ISA:AgBase.
GO; GO:0007281; P:germ cell development; ISA:AgBase.
GO; GO:0032836; P:glomerular basement membrane development; ISA:AgBase.
GO; GO:0072015; P:glomerular visceral epithelial cell development; ISA:AgBase.
GO; GO:0072112; P:glomerular visceral epithelial cell differentiation; ISA:AgBase.
GO; GO:0032835; P:glomerulus development; ISA:AgBase.
GO; GO:0008406; P:gonad development; IEP:AgBase.
GO; GO:0007507; P:heart development; ISA:AgBase.
GO; GO:0001822; P:kidney development; ISA:AgBase.
GO; GO:0030539; P:male genitalia development; ISA:AgBase.
GO; GO:0008584; P:male gonad development; ISA:AgBase.
GO; GO:0060231; P:mesenchymal to epithelial transition; ISA:AgBase.
GO; GO:0001823; P:mesonephros development; ISA:AgBase.
GO; GO:0072278; P:metanephric comma-shaped body morphogenesis; ISA:AgBase.
GO; GO:0072207; P:metanephric epithelium development; ISA:AgBase.
GO; GO:0072075; P:metanephric mesenchyme development; ISA:AgBase.
GO; GO:0072284; P:metanephric S-shaped body morphogenesis; ISA:AgBase.
GO; GO:0001656; P:metanephros development; ISA:AgBase.
GO; GO:0043066; P:negative regulation of apoptotic process; ISA:AgBase.
GO; GO:0030308; P:negative regulation of cell growth; ISA:AgBase.
GO; GO:0008285; P:negative regulation of cell proliferation; ISA:AgBase.
GO; GO:2000195; P:negative regulation of female gonad development; ISA:AgBase.
GO; GO:1900212; P:negative regulation of mesenchymal cell apoptotic process involved in metanephros development; ISA:AgBase.
GO; GO:0072302; P:negative regulation of metanephric glomerular mesangial cell proliferation; ISA:AgBase.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISA:AgBase.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISA:AgBase.
GO; GO:0017148; P:negative regulation of translation; ISA:AgBase.
GO; GO:0043065; P:positive regulation of apoptotic process; ISA:AgBase.
GO; GO:0060421; P:positive regulation of heart growth; ISA:AgBase.
GO; GO:2000020; P:positive regulation of male gonad development; ISA:AgBase.
GO; GO:2001076; P:positive regulation of metanephric ureteric bud development; ISA:AgBase.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISA:AgBase.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISA:AgBase.
GO; GO:0072166; P:posterior mesonephric tubule development; ISA:AgBase.
GO; GO:0003156; P:regulation of animal organ formation; ISA:AgBase.
GO; GO:0010468; P:regulation of gene expression; ISA:AgBase.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISA:AgBase.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISA:AgBase.
GO; GO:0008380; P:RNA splicing; ISA:AgBase.
GO; GO:0072520; P:seminiferous tubule development; ISA:AgBase.
GO; GO:0060009; P:Sertoli cell development; ISA:AgBase.
GO; GO:0007530; P:sex determination; ISA:AgBase.
GO; GO:0007338; P:single fertilization; ISA:AgBase.
GO; GO:0007283; P:spermatogenesis; ISA:AgBase.
GO; GO:0007356; P:thorax and anterior abdomen determination; ISA:AgBase.
GO; GO:0009888; P:tissue development; ISA:AgBase.
GO; GO:0006366; P:transcription from RNA polymerase II promoter; ISA:AgBase.
GO; GO:0001657; P:ureteric bud development; ISA:AgBase.
GO; GO:0001570; P:vasculogenesis; ISA:AgBase.
GO; GO:0061032; P:visceral serous pericardium development; ISA:AgBase.
InterPro; IPR017987; Wilms_tumour.
InterPro; IPR000976; Wilms_tumour_N.
InterPro; IPR013087; Znf_C2H2_type.
Pfam; PF02165; WT1; 1.
PRINTS; PR00049; WILMSTUMOUR.
SMART; SM00355; ZnF_C2H2; 4.
SUPFAM; SSF57667; SSF57667; 2.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
2: Evidence at transcript level;
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
DOMAIN 290 319 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 320 349 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 350 377 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 378 407 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
SEQUENCE 413 AA; 46588 MW; EC9E20715059D136 CRC64;
MGSDVRDMNT LLPPVSSLAG NSSCNVPVNS SAQWAPVLDF PPGAPYTSLA PHSFIKQEPA
WNPDLHEDQC LSAFTVHFSG QFTGTAGACR YGAFGAPPPS QAFKGQPRMF PNSPYLPKCL
ENQQGIRNQG YSAMVFDGTP SYGHTPSHHT AQFPNHSFKH EDPITQQSSL GDQQYSVPPP
VYGCHTPTDS CTGSQALLLR SPYNSDNLYQ MTSQLECMTW NQMNLSSSLK GHGTTYENDS
HSTPMLYSCG GQYRIHTHGV FRGLQDVRRV PGVTPAIVRS STETNEKRPF MCAYPGCNKR
YLKLSHLQMH SRKHTGEKPY QCDLKDCERR FSRSDQLKRH QRRHTGVKPF QCKTCQRKFS
RSDHLKTHTR THTGEKPFSC RWPSCQKKFA RSDELVRHHN MHQRNMTKLQ LAL


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