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Wilms tumor protein homolog

 WT1_XENTR               Reviewed;         413 AA.
B5DE03;
09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
14-OCT-2008, sequence version 1.
22-NOV-2017, entry version 51.
RecName: Full=Wilms tumor protein homolog {ECO:0000250|UniProtKB:P22561};
Name=wt1;
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Silurana.
NCBI_TaxID=8364;
[1] {ECO:0000312|EMBL:AAI68476.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis {ECO:0000312|EMBL:AAI68476.1};
NIH - Xenopus Gene Collection (XGC) project;
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Transcription factor required for development of the
vascular component of the pronephric kidney, the glomus; may
repress tubule-specific gene expression in the portion of the
pronephros fated to form the glomus (By similarity). Recognizes
and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity).
Inhibits Wnt-signaling during embryonic development (By
similarity). {ECO:0000250|UniProtKB:B7ZSG3,
ECO:0000250|UniProtKB:P19544}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P22561}.
Cytoplasm {ECO:0000250|UniProtKB:P22561}. Nucleus speckle
{ECO:0000250|UniProtKB:P22561}. Note=Shuttles between nucleus and
cytoplasm. {ECO:0000250|UniProtKB:P22561}.
-!- DOMAIN: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3'
via its C2H2-type zinc fingers. Starting from the N-terminus, the
second zinc finger binds to the 3'-GCG motif, the middle zinc
finger interacts with the central TGG motif, and the C-terminal
zinc finger binds to the 5'-GCG motif. Binds double-stranded
target DNA, irrespective of the cytosine methylation status. Has
reduced affinity for target DNA where the cytosines have been
oxidized to 5-hydroxymethylcytosine, 5-formylcytosine or 5-
carboxylcytosine. {ECO:0000250|UniProtKB:P19544}.
-!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein
family. {ECO:0000255}.
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EMBL; BC168476; AAI68476.1; -; mRNA.
RefSeq; NP_001135625.1; NM_001142153.1.
UniGene; Str.44768; -.
SMR; B5DE03; -.
GeneID; 100216184; -.
KEGG; xtr:100216184; -.
CTD; 7490; -.
Xenbase; XB-GENE-484999; wt1.
HOGENOM; HOG000230937; -.
HOVERGEN; HBG006960; -.
InParanoid; B5DE03; -.
KO; K09234; -.
Proteomes; UP000008143; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO; GO:0010385; F:double-stranded methylated DNA binding; ISS:UniProtKB.
GO; GO:0044729; F:hemi-methylated DNA-binding; ISS:UniProtKB.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO; GO:0072112; P:glomerular visceral epithelial cell differentiation; IBA:GO_Central.
GO; GO:0072013; P:glomus development; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell proliferation; IBA:GO_Central.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
GO; GO:0048793; P:pronephros development; ISS:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR017987; Wilms_tumour.
InterPro; IPR000976; Wilms_tumour_N.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
Pfam; PF02165; WT1; 1.
PRINTS; PR00049; WILMSTUMOUR.
SMART; SM00355; ZnF_C2H2; 4.
SUPFAM; SSF57667; SSF57667; 2.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
2: Evidence at transcript level;
Complete proteome; Cytoplasm; Developmental protein; DNA-binding;
Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Repeat;
RNA editing; RNA-binding; Transcription; Transcription regulation;
Tumor suppressor; Ubl conjugation; Wnt signaling pathway; Zinc;
Zinc-finger.
CHAIN 1 413 Wilms tumor protein homolog.
/FTId=PRO_0000391389.
ZN_FING 290 314 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 320 344 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 350 372 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 378 402 C2H2-type 4. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
REGION 334 348 Important for interaction with target
DNA. {ECO:0000250|UniProtKB:P19544}.
REGION 360 368 Important for interaction with target
DNA. {ECO:0000250|UniProtKB:P19544}.
SITE 388 388 Important for interaction with target
DNA. {ECO:0000250|UniProtKB:P19544}.
SITE 394 394 Important for interaction with target
DNA. {ECO:0000250|UniProtKB:P19544}.
CROSSLNK 56 56 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250|UniProtKB:P19544}.
CROSSLNK 159 159 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250|UniProtKB:P19544}.
SEQUENCE 413 AA; 46461 MW; CF62CB23A13C58A8 CRC64;
MGSDVRDMNA LLPPVSTLSG NSSCSMPVSS SGQWAPVLDF PPGAPYSSLP PHSFIKQEPT
WNPDPHEDQC LSAFTVHFSG QFTGTAGACR YGAFGAPTPS QATTGQARMF PNSPYLSNCL
DNQQGMRNQG YSAVAFDGTP SYGHTPSHHT AQFTNHSFKH EDPMGQQTSL GEQQYSVPPP
VYGCHTPTDS CTGSQALLLR TPYNSDNLYQ MTSQLECMTW NQMNLGSSLK SHGTSYENDS
HSTPMLYSCG GQYRIHTHGV FRGIQDVRRV PGVTPAIVRS STEANEKRPF MCAYPGCNKR
YFKLSHLQMH SRKHTGEKPY QCDFKDCERR FSRSDQLKRH QRRHTGIKPF QCKTCQRKFS
RSDHLKTHTR THTGEKPFSC RWPSCQKKFA RSDELVRHHN MHQRNMTKLQ LAL


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