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Wilms tumor protein homolog B (XWT1b) (XeWT1)

 WT1B_XENLA              Reviewed;         407 AA.
P79958;
09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
25-OCT-2017, entry version 92.
RecName: Full=Wilms tumor protein homolog B;
Short=XWT1b {ECO:0000303|PubMed:16818449};
Short=XeWT1 {ECO:0000303|PubMed:8917094};
Name=wt1-b; Synonyms=wt1 {ECO:0000312|EMBL:BAA11522.1};
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1] {ECO:0000305, ECO:0000312|EMBL:BAA11522.1}
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Testis {ECO:0000312|EMBL:BAA11522.1};
PubMed=8917094; DOI=10.1016/0378-1119(96)00143-6;
Semba K., Saito-Ueno R., Takayama G., Kondo M.;
"cDNA cloning and its pronephros-specific expression of the Wilms'
tumor suppressor gene, WT1, from Xenopus laevis.";
Gene 175:167-172(1996).
[2] {ECO:0000305}
FUNCTION.
PubMed=16818449; DOI=10.1242/dev.02458;
Taelman V., Van Campenhout C., Soelter M., Pieler T., Bellefroid E.J.;
"The Notch-effector HRT1 gene plays a role in glomerular development
and patterning of the Xenopus pronephros anlagen.";
Development 133:2961-2971(2006).
-!- FUNCTION: Transcription factor required for development of the
vascular component of the pronephric kidney, the glomus; may
repress tubule-specific gene expression in the portion of the
pronephros fated to form the glomus (PubMed:16818449). Recognizes
and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity).
Inhibits Wnt-signaling during embryonic development (By
similarity). {ECO:0000250|UniProtKB:B7ZSG3,
ECO:0000250|UniProtKB:P19544, ECO:0000269|PubMed:16818449}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P22561}.
Cytoplasm {ECO:0000250|UniProtKB:P22561}. Nucleus speckle
{ECO:0000250|UniProtKB:P22561}. Note=Shuttles between nucleus and
cytoplasm. {ECO:0000250|UniProtKB:P22561}.
-!- TISSUE SPECIFICITY: Expressed in the pronephric anlage from stage
23 to 30. Also expressed in the adult kidney (mesonephros) and in
testis. {ECO:0000269|PubMed:8917094}.
-!- DOMAIN: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3'
via its C2H2-type zinc fingers. Starting from the N-terminus, the
second zinc finger binds to the 3'-GCG motif, the middle zinc
finger interacts with the central TGG motif, and the C-terminal
zinc finger binds to the 5'-GCG motif. Binds double-stranded
target DNA, irrespective of the cytosine methylation status. Has
reduced affinity for target DNA where the cytosines have been
oxidized to 5-hydroxymethylcytosine, 5-formylcytosine or 5-
carboxylcytosine. {ECO:0000250|UniProtKB:P19544}.
-!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein
family. {ECO:0000255}.
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EMBL; D82051; BAA11522.1; -; mRNA.
PIR; JC5046; JC5046.
RefSeq; NP_001079336.1; NM_001085867.1.
UniGene; Xl.246; -.
ProteinModelPortal; P79958; -.
SMR; P79958; -.
GeneID; 378664; -.
KEGG; xla:378664; -.
CTD; 378664; -.
Xenbase; XB-GENE-6252376; wt1.
HOVERGEN; HBG006960; -.
KO; K09234; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO; GO:0010385; F:double-stranded methylated DNA binding; ISS:UniProtKB.
GO; GO:0044729; F:hemi-methylated DNA-binding; ISS:UniProtKB.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO; GO:0072013; P:glomus development; IMP:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
GO; GO:0048793; P:pronephros development; IEP:UniProtKB.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
Gene3D; 2.40.155.10; -; 1.
InterPro; IPR009017; GFP.
InterPro; IPR017987; Wilms_tumour.
InterPro; IPR000976; Wilms_tumour_N.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
Pfam; PF02165; WT1; 1.
PRINTS; PR00049; WILMSTUMOUR.
SMART; SM00355; ZnF_C2H2; 4.
SUPFAM; SSF57667; SSF57667; 2.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
2: Evidence at transcript level;
Cytoplasm; Developmental protein; DNA-binding; Isopeptide bond;
Metal-binding; Nucleus; Repeat; RNA editing; RNA-binding;
Transcription; Transcription regulation; Tumor suppressor;
Ubl conjugation; Wnt signaling pathway; Zinc; Zinc-finger.
CHAIN 1 407 Wilms tumor protein homolog B.
/FTId=PRO_0000391388.
ZN_FING 284 308 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 314 338 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 344 366 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 372 396 C2H2-type 4. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
REGION 328 342 Important for interaction with target
DNA. {ECO:0000250|UniProtKB:P19544}.
REGION 354 362 Important for interaction with target
DNA. {ECO:0000250|UniProtKB:P19544}.
SITE 382 382 Important for interaction with target
DNA. {ECO:0000250|UniProtKB:P19544}.
SITE 388 388 Important for interaction with target
DNA. {ECO:0000250|UniProtKB:P19544}.
CROSSLNK 55 55 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250|UniProtKB:P19544}.
CROSSLNK 158 158 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250|UniProtKB:P19544}.
SEQUENCE 407 AA; 45983 MW; E2554C658005870C CRC64;
MGSDVRDMNL LPPVSSLSGN SSCNMPVSNS SQWAPVLDFP PGAPYSSLTP HSFIKQEPTW
NPDPHEDQCL SAFTVHFSGQ FTGTAGACRY GPFGAPTPSQ ATTGQARMFP NAPYLSNCLD
NQQSMRNQGY SAVAFDGTPS YGHTPSHHTA QFTNHSFKHE DPISQQTSLG EQQYSVPPPV
YGCHTPTDTC TGSQALLLRT PYNSDNLYQM ECMTWNQMNL GSSLKSHGTT YENDSHSAPM
LYSCGGQYRI HTHGVFRGIQ DVRRVPGVTP AIVRSTEANE KRPFMCAYPG CNKRYFKLSH
LQMHSRKHTG EKPYQCDFKD CERRFSRSDQ LKRHQRRHTG VKPFQCKTCQ RKFSRSDHLK
THTRTHTGEK PFSCRWPSCQ KKFARSDELV RHHNMHQRNM TKLQLAL


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