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X-ray repair complementing defective repair in Chinese hamster cells 6, isoform CRA_a (X-ray repair cross-complementing 6) (Xrcc6 protein)

 Q6AZ64_RAT              Unreviewed;       608 AA.
Q6AZ64;
13-SEP-2004, integrated into UniProtKB/TrEMBL.
13-SEP-2004, sequence version 1.
12-SEP-2018, entry version 125.
SubName: Full=X-ray repair complementing defective repair in Chinese hamster cells 6, isoform CRA_a {ECO:0000313|EMBL:EDM15680.1};
SubName: Full=X-ray repair cross-complementing 6 {ECO:0000313|Ensembl:ENSRNOP00000008819};
SubName: Full=Xrcc6 protein {ECO:0000313|EMBL:AAH78718.1};
Name=Xrcc6 {ECO:0000313|EMBL:AAH78718.1,
ECO:0000313|Ensembl:ENSRNOP00000008819, ECO:0000313|RGD:2643};
ORFNames=rCG_60269 {ECO:0000313|EMBL:EDM15680.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:AAH78718.1};
[1] {ECO:0000313|EMBL:AAH78718.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis {ECO:0000313|EMBL:AAH78718.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2] {ECO:0000313|Ensembl:ENSRNOP00000008819, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000008819,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[3] {ECO:0000313|EMBL:EDM15680.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDM15680.1};
PubMed=15632090; DOI=10.1101/gr.2889405;
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
Istrail S., Li P., Sutton G.;
"Gene and alternative splicing annotation with AIR.";
Genome Res. 15:54-66(2005).
[4] {ECO:0000313|EMBL:EDM15680.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDM15680.1};
Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|Ensembl:ENSRNOP00000008819}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000008819};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AC128377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC078718; AAH78718.1; -; mRNA.
EMBL; CH473950; EDM15680.1; -; Genomic_DNA.
RefSeq; NP_620780.2; NM_139080.2.
UniGene; Rn.161996; -.
ComplexPortal; CPX-2048; Ku70:Ku80 complex.
IntAct; Q6AZ64; 1.
PRIDE; Q6AZ64; -.
Ensembl; ENSRNOT00000008819; ENSRNOP00000008819; ENSRNOG00000006392.
GeneID; 25019; -.
KEGG; rno:25019; -.
CTD; 2547; -.
RGD; 2643; Xrcc6.
eggNOG; KOG2327; Eukaryota.
eggNOG; ENOG410XNXU; LUCA.
GeneTree; ENSGT00390000001422; -.
HOGENOM; HOG000006588; -.
HOVERGEN; HBG006236; -.
KO; K10884; -.
Reactome; R-RNO-5693571; Nonhomologous End-Joining (NHEJ).
Reactome; R-RNO-6798695; Neutrophil degranulation.
Proteomes; UP000002494; Chromosome 7.
Bgee; ENSRNOG00000006392; Expressed in 10 organ(s), highest expression level in spleen.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
GO; GO:0005730; C:nucleolus; IDA:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0032991; C:protein-containing complex; IDA:RGD.
GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
GO; GO:0007420; P:brain development; IEP:RGD.
GO; GO:0071475; P:cellular hyperosmotic salinity response; IDA:RGD.
GO; GO:0071481; P:cellular response to X-ray; IDA:RGD.
GO; GO:0006302; P:double-strand break repair; TAS:RGD.
GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
Gene3D; 1.10.720.30; -; 1.
Gene3D; 2.40.290.10; -; 2.
Gene3D; 3.40.50.410; -; 1.
Gene3D; 4.10.970.10; -; 1.
InterPro; IPR006165; Ku70.
InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
InterPro; IPR027388; Ku70_bridge/pillars_dom_sf.
InterPro; IPR005160; Ku_C.
InterPro; IPR005161; Ku_N.
InterPro; IPR003034; SAP_dom.
InterPro; IPR036361; SAP_dom_sf.
InterPro; IPR016194; SPOC-like_C_dom_sf.
InterPro; IPR036465; vWFA_dom_sf.
PANTHER; PTHR12604:SF2; PTHR12604:SF2; 1.
Pfam; PF02735; Ku; 1.
Pfam; PF03730; Ku_C; 1.
Pfam; PF03731; Ku_N; 1.
Pfam; PF02037; SAP; 1.
PIRSF; PIRSF003033; Ku70; 1.
SMART; SM00559; Ku78; 1.
SMART; SM00513; SAP; 1.
SUPFAM; SSF100939; SSF100939; 1.
SUPFAM; SSF53300; SSF53300; 1.
SUPFAM; SSF68906; SSF68906; 1.
TIGRFAMs; TIGR00578; ku70; 1.
PROSITE; PS50800; SAP; 1.
1: Evidence at protein level;
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Proteomics identification {ECO:0000213|PeptideAtlas:Q6AZ64};
Reference proteome {ECO:0000313|Proteomes:UP000002494}.
DOMAIN 571 605 SAP. {ECO:0000259|PROSITE:PS50800}.
ACT_SITE 29 29 Schiff-base intermediate with DNA; for
5*-deoxyribose-5-phosphate lyase
activity. {ECO:0000256|PIRSR:PIRSR003033-
1}.
SEQUENCE 608 AA; 69486 MW; D42E43CF0C23B716 CRC64;
MSEWESYYKT EGEEEEEEEQ SPDTNGEYKY SGRDSLIFLV DASRAMFESQ GEDELTPFDM
SIQCIQSVYT SKIISSDRDL LAVVFYGTEK DKNSVNFKSI YVLQDLDNPG AKRVLELDRF
KGQQGKKHFR DTIGHGSDYS LSEVLWVCAN LFSDVQFKMS HKRIMLFTNE DDPHGNDSAK
ASRARTKASD LRDTGIFLDL MHLKKRGGFD VSLFYRDIIS IAEDEDLGVH FEESSKLEDL
LRKVRAKETK KRVLSRLKFK LGKDVALMVG VYNLVQKANK PFPVRLYRET NEPVKTKTRT
FNVNTGSLLL PSDTKRSLTF GTRQIVLEKE ETEELKRFDE PGLILMGFKP MVMLKNHHYL
RPSLFLYPEE SLVNGSSTLF SALLTKCVEK EVIAVCRYTA RKNVSPYFVA LVPQEEELDD
QNIQVTPAGF QLVFLPYADD KRKVPFTEKV MANPEQIDKM KAIVQKLRFT YRSDSFENPV
LQQHFRNLEA LALDMMESEQ VVDLTLPKVE AIKKRLGSLA DEFKELVYPP GYNPEGKIAK
RKADNEGSAS KKPKVELSEE ELKDLFAKGT LGKLTVPALR DICKAYGLKS GPKKQELLEA
LSRHLEKN


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