Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP/AP lyase Ku70) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (DNA repair protein XRCC6) (Ku autoantigen protein p70 homolog) (Ku70)

 XRCC6_CHICK             Reviewed;         632 AA.
O93257;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
23-MAY-2018, entry version 120.
RecName: Full=X-ray repair cross-complementing protein 5;
EC=3.6.4.-;
EC=4.2.99.-;
AltName: Full=5'-deoxyribose-5-phosphate lyase Ku70;
Short=5'-dRP/AP lyase Ku70;
AltName: Full=ATP-dependent DNA helicase 2 subunit 1;
AltName: Full=ATP-dependent DNA helicase II 70 kDa subunit;
AltName: Full=DNA repair protein XRCC6;
AltName: Full=Ku autoantigen protein p70 homolog;
Short=Ku70;
Name=XRCC6; Synonyms=G22P1, KU70;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Intestinal mucosa;
PubMed=9736627; DOI=10.1093/emboj/17.18.5497;
Takata M., Sasaki M.S., Sonoda E., Morrison C., Hashimoto M.,
Utsumi H., Yamaguchi-Iwai Y., Shinohara A., Takeda S.;
"Homologous recombination and non-homologous end-joining pathways of
DNA double-strand break repair have overlapping roles in the
maintenance of chromosomal integrity in vertebrate cells.";
EMBO J. 17:5497-5508(1998).
-!- FUNCTION: Single-stranded DNA-dependent ATP-dependent helicase.
Has a role in chromosome translocation. The DNA helicase II
complex binds preferentially to fork-like ends of double-stranded
DNA in a cell cycle-dependent manner. It works in the 3'-5'
direction. Binding to DNA may be mediated by XRCC6. Involved in
DNA non-homologous end joining (NHEJ) required for double-strand
break repair and V(D)J recombination. The XRCC5/6 dimer acts as
regulatory subunit of the DNA-dependent protein kinase complex
DNA-PK by increasing the affinity of the catalytic subunit PRKDC
to DNA by 100-fold. The XRCC5/6 dimer is probably involved in
stabilizing broken DNA ends and bringing them together. The
assembly of the DNA-PK complex to DNA ends is required for the
NHEJ ligation step. Probably also acts as a 5'-deoxyribose-5-
phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination
of the 5' deoxyribose-5-phosphate at an abasic site near double-
strand breaks. 5'-dRP lyase activity allows to 'clean' the termini
of abasic sites, a class of nucleotide damage commonly associated
with strand breaks, before such broken ends can be joined. The
XRCC5/6 dimer together with APEX1 acts as a negative regulator of
transcription (By similarity). {ECO:0000250}.
-!- SUBUNIT: Heterodimer composed of XRCC5/Ku80 and XRCC6/Ku70. The
dimer associates in a DNA-dependent manner with PRKDC to form the
DNA-dependent protein kinase complex DNA-PK, and with the LIG4-
XRCC4 complex to form the core of the non-homologous end joining
(NHEJ) complex. Additional components of the NHEJ complex include
NHEJ1/XLF and PAXX. {ECO:0000250|UniProtKB:P12956,
ECO:0000250|UniProtKB:P23475}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
{ECO:0000250}.
-!- PTM: Phosphorylated on serine residues. {ECO:0000250}.
-!- SIMILARITY: Belongs to the ku70 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AB016529; BAA32018.1; -; mRNA.
RefSeq; NP_990258.2; NM_204927.2.
UniGene; Gga.26690; -.
ProteinModelPortal; O93257; -.
SMR; O93257; -.
BioGrid; 676041; 2.
STRING; 9031.ENSGALP00000037185; -.
PaxDb; O93257; -.
PRIDE; O93257; -.
GeneID; 395767; -.
KEGG; gga:395767; -.
CTD; 2547; -.
eggNOG; KOG2327; Eukaryota.
eggNOG; ENOG410XNXU; LUCA.
HOGENOM; HOG000006588; -.
HOVERGEN; HBG006236; -.
InParanoid; O93257; -.
KO; K10884; -.
PhylomeDB; O93257; -.
Reactome; R-GGA-353423; Non-homologous end joining (NHEJ).
PRO; PR:O93257; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0043564; C:Ku70:Ku80 complex; ISS:UniProtKB.
GO; GO:0070419; C:nonhomologous end joining complex; ISS:UniProtKB.
GO; GO:0000784; C:nuclear chromosome, telomeric region; IBA:GO_Central.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:1990904; C:ribonucleoprotein complex; ISS:UniProtKB.
GO; GO:0051575; F:5'-deoxyribose-5-phosphate lyase activity; ISS:UniProtKB.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
GO; GO:0071480; P:cellular response to gamma radiation; ISS:UniProtKB.
GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.720.30; -; 1.
Gene3D; 2.40.290.10; -; 2.
Gene3D; 3.40.50.410; -; 1.
Gene3D; 4.10.970.10; -; 1.
InterPro; IPR006165; Ku70.
InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
InterPro; IPR027388; Ku70_bridge/pillars_dom_sf.
InterPro; IPR005160; Ku_C.
InterPro; IPR005161; Ku_N.
InterPro; IPR003034; SAP_dom.
InterPro; IPR036361; SAP_dom_sf.
InterPro; IPR016194; SPOC-like_C_dom_sf.
InterPro; IPR036465; vWFA_dom_sf.
PANTHER; PTHR12604:SF2; PTHR12604:SF2; 1.
Pfam; PF02735; Ku; 1.
Pfam; PF03730; Ku_C; 1.
Pfam; PF03731; Ku_N; 1.
Pfam; PF02037; SAP; 1.
PIRSF; PIRSF003033; Ku70; 1.
SMART; SM00559; Ku78; 1.
SMART; SM00513; SAP; 1.
SUPFAM; SSF100939; SSF100939; 1.
SUPFAM; SSF53300; SSF53300; 1.
SUPFAM; SSF68906; SSF68906; 1.
TIGRFAMs; TIGR00578; ku70; 1.
PROSITE; PS50800; SAP; 1.
2: Evidence at transcript level;
Activator; ATP-binding; Chromosome; Complete proteome; DNA damage;
DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase;
Lyase; Multifunctional enzyme; Nucleotide-binding; Nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 632 X-ray repair cross-complementing protein
5.
/FTId=PRO_0000210181.
DOMAIN 283 490 Ku.
DOMAIN 595 629 SAP. {ECO:0000255|PROSITE-
ProRule:PRU00186}.
COMPBIAS 32 43 Asp/Glu-rich (acidic).
ACT_SITE 52 52 Schiff-base intermediate with DNA; for
5'-deoxyribose-5-phosphate lyase
activity. {ECO:0000250}.
SEQUENCE 632 AA; 72289 MW; 5EB391674459B1C0 CRC64;
MEMWVLGEVG MAVLSAAAMA DWVSYYRGDG PDEEEDGEQQ EEEGPEAVAD YRFSGRDSLI
FLVDASKAMF EPYENEEAAT PFDMTMQCIR NVYTSKIISS DKDLLSVVFY GMENNKNSAD
FKHIYVLQEL DNPGAKRILE LDQYRGDEGR VLFRETFGHN ADYSLGEALW ACSNLFSDVR
VRLSHKRIML FTNEDNPHAN DSAKAKLART RAGDLRDTGI ILDLMHLKKP GGFDISLFYR
DIINVAEDED LGIQPDESGK LEHLMKKVRA KETRKRALSR LNLYLNKDLS FSVGVYNLIQ
KAYKPYPVKL YRETNEPVKT KTRVFNGKTG SLLLPSDTKR AQTYGNRQIA MEKEETEEVK
RFDSPGLFLI GFKPLSMLKQ HHHIRPSQFM YPEESLVTGS TTLFNALLMK CLEKEVMALC
RYIARRNTPP RIVALIPQEE EVDEQKVQIA PPGFHIIFLP YADDKRNVDF TEKVPANREQ
VDKMKGIIQK LRFKYRTDSF ENPVLQQHFR NLEALALDML EPEQAEDLTM PKTEEMSRRL
GNLVEEFKQL VYPPDYSPEG KAAKRKQAGD AQAEKRPKIE ISEDSLRSYV QNGTLGKLTV
SALKDTCRHY GLRSGGKKQE LIDALTEYFS GR


Related products :

Catalog number Product name Quantity
EIAAB46587 5'-deoxyribose-5-phosphate lyase Ku70,5'-dRP_AP lyase Ku70,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,Chicken,DNA repair protein XRCC6,G22P1,Gallus gallus,Ku a
EIAAB46585 5'-deoxyribose-5-phosphate lyase Ku70,5'-dRP_AP lyase Ku70,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit,CTC75,CTCBF,DNA rep
EIAAB46586 5'-deoxyribose-5-phosphate lyase Ku70,5'-dRP lyase Ku70,70 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa s
EIAAB46583 ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit,CTC85,CTCBF,DNA repair protein XRCC5,G22p2,Ku autoantigen protein p86 homolog,
18-003-42479 ATP-dependent DNA helicase 2 subunit 1 - EC 3.6.1.-; ATP-dependent DNA helicase II 70 kDa subunit; Lupus Ku autoantigen protein p70; Ku70; 70 kDa subunit of Ku antigen; Thyroid-lupus autoantigen; TLAA 0.1 mg Protein A
18-003-42478 ATP-dependent DNA helicase 2 subunit 1 - EC 3.6.1.-; ATP-dependent DNA helicase II 70 kDa subunit; Lupus Ku autoantigen protein p70; Ku70; 70 kDa subunit of Ku antigen; Thyroid-lupus autoantigen; TLAA 0.1 mg Protein A
20-372-60301 X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen. 70kDa) - Mouse monoclonal anti-human XRCC6 antibody; ATP-dependent DNA helicase II 70 kDa subunit; Lupus Ku auto 0.1 mg
EIAAB46584 86 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit,CTC85,CTCBF,DNA repair protein XRCC5,G22P2,Homo s
EIAAB13174 Bos taurus,Bovine,CXPD,DNA excision repair protein ERCC-2,DNA repair protein complementing XP-D cells,ERCC2,TFIIH basal transcription factor complex helicase XPD subunit,Xeroderma pigmentosum group D-
EIAAB13176 CXPD,DNA excision repair protein ERCC-2,DNA repair protein complementing XP-D cells,Ercc2,Mouse,Mus musculus,TFIIH basal transcription factor complex helicase XPD subunit,Xeroderma pigmentosum group D
10-663-45671 Ku Protein (P70_P80) Human - EC 3.6.1.-; ATP-dependent DNA helicase II 80 kDa subunit; Lupus Ku autoantigen protein p86; Ku86; Ku80; 86 kDa subunit of Ku antigen; Thyroid-lupus autoantigen; TLAA; CTC 1 mg
10-663-45671 Ku Protein (P70_P80) Human - EC 3.6.1.-; ATP-dependent DNA helicase II 80 kDa subunit; Lupus Ku autoantigen protein p86; Ku86; Ku80; 86 kDa subunit of Ku antigen; Thyroid-lupus autoantigen; TLAA; CTC 0.02 mg
10-663-45671 Ku Protein (P70_P80) Human - EC 3.6.1.-; ATP-dependent DNA helicase II 80 kDa subunit; Lupus Ku autoantigen protein p86; Ku86; Ku80; 86 kDa subunit of Ku antigen; Thyroid-lupus autoantigen; TLAA; CTC 0.005 mg
EIAAB13173 ATP-dependent helicase ERCC6-like,DNA excision repair protein ERCC-6-like,ERCC6L,Homo sapiens,Human,PICH,PLK1-interacting checkpoint helicase,Tumor antigen BJ-HCC-15
EIAAB07136 ATP-dependent helicase CHD3,CHD3,CHD-3,Chromodomain-helicase-DNA-binding protein 3,Homo sapiens,Human,hZFH,Mi-2 autoantigen 240 kDa protein,Mi2-alpha,Zinc finger helicase
EIAAB13178 Basic transcription factor 2 89 kDa subunit,BTF2 p89,DNA excision repair protein ERCC-3,DNA repair protein complementing XP-B cells,Ercc3,Mouse,Mus musculus,TFIIH 89 kDa subunit,TFIIH basal transcript
EIAAB13181 Basic transcription factor 2 89 kDa subunit,BTF2 p89,DNA excision repair protein ERCC-3,DNA repair protein complementing XP-B cells,ERCC3,Homo sapiens,Human,TFIIH 89 kDa subunit,TFIIH basal transcript
EIAAB13175 Basic transcription factor 2 80 kDa subunit,BTF2 p80,CXPD,DNA excision repair protein ERCC-2,DNA repair protein complementing XP-D cells,ERCC2,Homo sapiens,Human,TFIIH 80 kDa subunit,TFIIH basal trans
EIAAB46542 DNA excision repair protein ERCC-4,DNA repair endonuclease XPF,DNA repair protein complementing XP-F cells,ERCC11,ERCC4,Homo sapiens,Human,Xeroderma pigmentosum group F-complementing protein,XPF
EIAAB13171 ATP-dependent helicase ERCC6-like,Bos taurus,Bovine,DNA excision repair protein ERCC-6-like,ERCC6L
EIAAB13172 ATP-dependent helicase ERCC6-like,DNA excision repair protein ERCC-6-like,Ercc6l,Mouse,Mus musculus
EIAAB13183 DNA excision repair protein ERCC-5,DNA repair protein complementing XP-G cells homolog,Ercc5,Ercc-5,Mouse,Mus musculus,Xeroderma pigmentosum group G-complementing protein homolog,Xpg
EIAAB07137 ATP-dependent helicase CHD4,CHD4,CHD-4,Chromodomain-helicase-DNA-binding protein 4,Homo sapiens,Human,Mi-2 autoantigen 218 kDa protein,Mi2-beta
EIAAB10832 ATP-dependent RNA helicase p54,Ddx6,DEAD box protein 6,Hlr2,Mouse,Mus musculus,Oncogene RCK homolog,Probable ATP-dependent RNA helicase DDX6,Rck
EIAAB13184 ATP-dependent helicase ERCC6,Cockayne syndrome protein CSB,CSB,DNA excision repair protein ERCC-6,ERCC6,Homo sapiens,Human


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur