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Xanthine phosphoribosyltransferase (EC 2.4.2.22) (Fragment)

 Q4U2M8_STREE            Unreviewed;       162 AA.
Q4U2M8;
19-JUL-2005, integrated into UniProtKB/TrEMBL.
19-JUL-2005, sequence version 1.
05-JUL-2017, entry version 56.
RecName: Full=Xanthine phosphoribosyltransferase {ECO:0000256|SAAS:SAAS00756469};
EC=2.4.2.22 {ECO:0000256|SAAS:SAAS00756469};
Flags: Fragment;
Name=xpt {ECO:0000313|EMBL:CAA13409.1};
Streptococcus pneumoniae.
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
Streptococcus.
NCBI_TaxID=1313 {ECO:0000313|EMBL:CAA13409.1};
[1] {ECO:0000313|EMBL:CAA13409.1}
NUCLEOTIDE SEQUENCE.
PubMed=9846740;
Enright M.C., Spratt B.G.;
"A multilocus sequence typing scheme for Streptococcus pneumoniae:
identification of clones associated with serious invasive disease.";
Microbiology 144:3049-3060(1998).
[2] {ECO:0000313|EMBL:ABR03249.1}
NUCLEOTIDE SEQUENCE.
STRAIN=0g {ECO:0000313|EMBL:ABR03249.1},
0h {ECO:0000313|EMBL:ABR03250.1}, 0i {ECO:0000313|EMBL:ABR03251.1},
327.1FR95 {ECO:0000313|EMBL:ABR03261.1},
335.1SP99 {ECO:0000313|EMBL:ABR03262.1},
335.2SP99 {ECO:0000313|EMBL:ABR03263.1},
335.3SP99 {ECO:0000313|EMBL:ABR03264.1},
336.1UK94 {ECO:0000313|EMBL:ABR03265.1},
336.1ZA98 {ECO:0000313|EMBL:ABR03266.1},
347.1SP95 {ECO:0000313|EMBL:ABR03267.1},
347.2SP95 {ECO:0000313|EMBL:ABR03268.1},
348.1SP95 {ECO:0000313|EMBL:ABR03269.1},
355.1SP96 {ECO:0000313|EMBL:ABR03271.1},
365.2SP96 {ECO:0000313|EMBL:ABR03273.1},
380.10SP95 {ECO:0000313|EMBL:ABR03274.1},
380.11SP95 {ECO:0000313|EMBL:ABR03275.1},
380.12SP96 {ECO:0000313|EMBL:ABR03276.1},
380.13SP97 {ECO:0000313|EMBL:ABR03277.1},
380.15SP97 {ECO:0000313|EMBL:ABR03278.1},
380.16SP99 {ECO:0000313|EMBL:ABR03279.1},
380.1FR00 {ECO:0000313|EMBL:ABR03280.1},
380.3IS99 {ECO:0000313|EMBL:ABR03281.1},
380.7SL99 {ECO:0000313|EMBL:ABR03283.1},
380.8SP00 {ECO:0000313|EMBL:ABR03284.1},
380.9SP94 {ECO:0000313|EMBL:ABR03285.1},
393.1FR95 {ECO:0000313|EMBL:ABR03286.1},
393.1SP95 {ECO:0000313|EMBL:ABR03287.1},
393.2SP95 {ECO:0000313|EMBL:ABR03289.1},
393.3FR95 {ECO:0000313|EMBL:ABR03290.1},
393.3SP95 {ECO:0000313|EMBL:ABR03291.1},
393.4FR95 {ECO:0000313|EMBL:ABR03292.1},
393.4SP95 {ECO:0000313|EMBL:ABR03293.1},
393.5SP95 {ECO:0000313|EMBL:ABR03294.1},
393.6SP95 {ECO:0000313|EMBL:ABR03295.1},
405.10SP94 {ECO:0000313|EMBL:ABR03296.1},
405.11SP94 {ECO:0000313|EMBL:ABR03297.1},
405.13SP94 {ECO:0000313|EMBL:ABR03298.1},
405.14SP95 {ECO:0000313|EMBL:ABR03299.1},
405.15SP95 {ECO:0000313|EMBL:ABR03300.1},
405.16SW99 {ECO:0000313|EMBL:ABR03301.1},
405.1BE96 {ECO:0000313|EMBL:ABR03302.1},
405.2BE97 {ECO:0000313|EMBL:ABR03303.1},
405.3BE99 {ECO:0000313|EMBL:ABR03304.1},
405.4FR94 {ECO:0000313|EMBL:ABR03305.1},
405.5FR94 {ECO:0000313|EMBL:ABR03306.1},
405.7PR00 {ECO:0000313|EMBL:ABR03307.1},
405.8PR98 {ECO:0000313|EMBL:ABR03308.1},
405.9PR99 {ECO:0000313|EMBL:ABR03309.1},
435.1SP95 {ECO:0000313|EMBL:ABR03311.1},
462.1FR96 {ECO:0000313|EMBL:ABR03320.1},
489.1Ca99 {ECO:0000313|EMBL:ABR03324.1},
530.1FR96 {ECO:0000313|EMBL:ABR03340.1},
585.1FR94 {ECO:0000313|EMBL:ABR03353.1},
595.2FR99 {ECO:0000313|EMBL:ABR03358.1},
598.1FR95 {ECO:0000313|EMBL:ABR03362.1},
606.2FR98 {ECO:0000313|EMBL:ABR03372.1},
615.4Oh00 {ECO:0000313|EMBL:ABR03374.1},
640.2FR94 {ECO:0000313|EMBL:ABR03379.1},
640.3FR96 {ECO:0000313|EMBL:ABR03380.1},
640.5IS99 {ECO:0000313|EMBL:ABR03382.1}, and
685.2FR99 {ECO:0000313|EMBL:ABR03411.1};
PubMed=17475572; DOI=10.1016/j.meegid.2007.03.004;
Stanhope M.J., Walsh S.L., Becker J.A., Miller L.A., Lefebure T.,
Lang P., Bitar P.D., Amrine-Madsen H.;
"The relative frequency of intraspecific lateral gene transfer of
penicillin binding proteins 1a, 2b, and 2x, in amoxicillin resistant
Streptococcus pneumoniae.";
Infect. Genet. Evol. 7:520-534(2007).
[3] {ECO:0000313|EMBL:AFK50336.1}
NUCLEOTIDE SEQUENCE.
STRAIN=101018015088 {ECO:0000313|EMBL:AFK50336.1};
PubMed=22815712; DOI=10.1371/journal.pone.0039630;
Boers S.A., van der Reijden W.A., Jansen R.;
"High-throughput multilocus sequence typing: bringing molecular typing
to the next level.";
PLoS ONE 7:E39630-E39630(2012).
-!- FUNCTION: Converts the preformed base xanthine, a product of
nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so
it can be reused for RNA or DNA synthesis.
{ECO:0000256|SAAS:SAAS00756464}.
-!- CATALYTIC ACTIVITY: XMP + diphosphate = 5-phospho-alpha-D-ribose
1-diphosphate + xanthine. {ECO:0000256|SAAS:SAAS00756462}.
-!- PATHWAY: Purine metabolism; XMP biosynthesis via salvage pathway;
XMP from xanthine: step 1/1. {ECO:0000256|SAAS:SAAS00756456}.
-!- SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS00756451}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756467}.
-!- SIMILARITY: Belongs to the purine/pyrimidine
phosphoribosyltransferase family. Xpt subfamily.
{ECO:0000256|SAAS:SAAS00756458}.
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EMBL; EF500874; ABR03249.1; -; Genomic_DNA.
EMBL; EF500875; ABR03250.1; -; Genomic_DNA.
EMBL; EF500876; ABR03251.1; -; Genomic_DNA.
EMBL; EF500886; ABR03261.1; -; Genomic_DNA.
EMBL; EF500887; ABR03262.1; -; Genomic_DNA.
EMBL; EF500888; ABR03263.1; -; Genomic_DNA.
EMBL; EF500889; ABR03264.1; -; Genomic_DNA.
EMBL; EF500890; ABR03265.1; -; Genomic_DNA.
EMBL; EF500891; ABR03266.1; -; Genomic_DNA.
EMBL; EF500892; ABR03267.1; -; Genomic_DNA.
EMBL; EF500893; ABR03268.1; -; Genomic_DNA.
EMBL; EF500894; ABR03269.1; -; Genomic_DNA.
EMBL; EF500896; ABR03271.1; -; Genomic_DNA.
EMBL; EF500898; ABR03273.1; -; Genomic_DNA.
EMBL; EF500899; ABR03274.1; -; Genomic_DNA.
EMBL; EF500900; ABR03275.1; -; Genomic_DNA.
EMBL; EF500901; ABR03276.1; -; Genomic_DNA.
EMBL; EF500902; ABR03277.1; -; Genomic_DNA.
EMBL; EF500903; ABR03278.1; -; Genomic_DNA.
EMBL; EF500904; ABR03279.1; -; Genomic_DNA.
EMBL; EF500905; ABR03280.1; -; Genomic_DNA.
EMBL; EF500906; ABR03281.1; -; Genomic_DNA.
EMBL; EF500908; ABR03283.1; -; Genomic_DNA.
EMBL; EF500909; ABR03284.1; -; Genomic_DNA.
EMBL; EF500910; ABR03285.1; -; Genomic_DNA.
EMBL; EF500911; ABR03286.1; -; Genomic_DNA.
EMBL; EF500912; ABR03287.1; -; Genomic_DNA.
EMBL; EF500914; ABR03289.1; -; Genomic_DNA.
EMBL; EF500915; ABR03290.1; -; Genomic_DNA.
EMBL; EF500916; ABR03291.1; -; Genomic_DNA.
EMBL; EF500917; ABR03292.1; -; Genomic_DNA.
EMBL; EF500918; ABR03293.1; -; Genomic_DNA.
EMBL; EF500919; ABR03294.1; -; Genomic_DNA.
EMBL; EF500920; ABR03295.1; -; Genomic_DNA.
EMBL; EF500921; ABR03296.1; -; Genomic_DNA.
EMBL; EF500922; ABR03297.1; -; Genomic_DNA.
EMBL; EF500923; ABR03298.1; -; Genomic_DNA.
EMBL; EF500924; ABR03299.1; -; Genomic_DNA.
EMBL; EF500925; ABR03300.1; -; Genomic_DNA.
EMBL; EF500926; ABR03301.1; -; Genomic_DNA.
EMBL; EF500927; ABR03302.1; -; Genomic_DNA.
EMBL; EF500928; ABR03303.1; -; Genomic_DNA.
EMBL; EF500929; ABR03304.1; -; Genomic_DNA.
EMBL; EF500930; ABR03305.1; -; Genomic_DNA.
EMBL; EF500931; ABR03306.1; -; Genomic_DNA.
EMBL; EF500932; ABR03307.1; -; Genomic_DNA.
EMBL; EF500933; ABR03308.1; -; Genomic_DNA.
EMBL; EF500934; ABR03309.1; -; Genomic_DNA.
EMBL; EF500936; ABR03311.1; -; Genomic_DNA.
EMBL; EF500945; ABR03320.1; -; Genomic_DNA.
EMBL; EF500949; ABR03324.1; -; Genomic_DNA.
EMBL; EF500965; ABR03340.1; -; Genomic_DNA.
EMBL; EF500978; ABR03353.1; -; Genomic_DNA.
EMBL; EF500983; ABR03358.1; -; Genomic_DNA.
EMBL; EF500987; ABR03362.1; -; Genomic_DNA.
EMBL; EF500997; ABR03372.1; -; Genomic_DNA.
EMBL; EF500999; ABR03374.1; -; Genomic_DNA.
EMBL; EF501004; ABR03379.1; -; Genomic_DNA.
EMBL; EF501005; ABR03380.1; -; Genomic_DNA.
EMBL; EF501007; ABR03382.1; -; Genomic_DNA.
EMBL; EF501036; ABR03411.1; -; Genomic_DNA.
EMBL; JQ740593; AFK50336.1; -; Genomic_DNA.
EMBL; AJ232406; CAA13409.1; -; Genomic_DNA.
eggNOG; ENOG4108UPS; Bacteria.
eggNOG; COG0503; LUCA.
UniPathway; UPA00602; UER00658.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0000310; F:xanthine phosphoribosyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
GO; GO:0046110; P:xanthine metabolic process; IEA:InterPro.
GO; GO:0032265; P:XMP salvage; IEA:UniProtKB-UniPathway.
CDD; cd06223; PRTases_typeI; 1.
InterPro; IPR000836; PRibTrfase_dom.
InterPro; IPR029057; PRTase-like.
InterPro; IPR010079; Xanthine_PRibTrfase.
PANTHER; PTHR43864:SF1; PTHR43864:SF1; 1.
Pfam; PF00156; Pribosyltran; 1.
SUPFAM; SSF53271; SSF53271; 1.
TIGRFAMs; TIGR01744; XPRTase; 1.
3: Inferred from homology;
Cytoplasm {ECO:0000256|SAAS:SAAS00756461};
Glycosyltransferase {ECO:0000256|SAAS:SAAS00756450,
ECO:0000313|EMBL:CAA13409.1};
Purine salvage {ECO:0000256|SAAS:SAAS00756453};
Transferase {ECO:0000256|SAAS:SAAS00756450,
ECO:0000313|EMBL:CAA13409.1}.
DOMAIN 20 139 Pribosyltran. {ECO:0000259|Pfam:PF00156}.
NON_TER 1 1 {ECO:0000313|EMBL:CAA13409.1}.
NON_TER 162 162 {ECO:0000313|EMBL:CAA13409.1}.
SEQUENCE 162 AA; 17361 MW; 344F4A7F4B8472AB CRC64;
DDNILKVDSF LTHQVDFSLM REIGKVFAEK FAAAGITKVV TIEASGIAPA VFTAEALNVP
MIFAKKAKNI TMNEGILTAQ VYSFTKQVTS TVSIAGKFLS PEDKVLIIDD FLANGQAAKG
LIQIIEQAGA TVQAIGIVIE KSFQDGRDLL EKAGYPVLSL AR


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