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Xanthine phosphoribosyltransferase (EC 2.4.2.22) (Fragment)

 Q4U2N0_STREE            Unreviewed;       162 AA.
Q4U2N0;
19-JUL-2005, integrated into UniProtKB/TrEMBL.
19-JUL-2005, sequence version 1.
05-JUL-2017, entry version 64.
RecName: Full=Xanthine phosphoribosyltransferase {ECO:0000256|SAAS:SAAS00756469};
EC=2.4.2.22 {ECO:0000256|SAAS:SAAS00756469};
Flags: Fragment;
Name=xpt {ECO:0000313|EMBL:CAA13407.1};
Streptococcus pneumoniae.
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
Streptococcus.
NCBI_TaxID=1313 {ECO:0000313|EMBL:CAA13407.1};
[1] {ECO:0000313|EMBL:CAA13407.1}
NUCLEOTIDE SEQUENCE.
PubMed=9846740;
Enright M.C., Spratt B.G.;
"A multilocus sequence typing scheme for Streptococcus pneumoniae:
identification of clones associated with serious invasive disease.";
Microbiology 144:3049-3060(1998).
[2] {ECO:0000313|EMBL:CAB60659.1}
NUCLEOTIDE SEQUENCE.
PubMed=10488179;
Enright M.C., Fenoll A., Griffiths D., Spratt B.G.;
"The three major Spanish clones of penicillin-resistant Streptococcus
pneumoniae are the most common clones recovered in recent cases of
meningitis in Spain.";
J. Clin. Microbiol. 37:3210-3216(1999).
[3] {ECO:0000313|EMBL:ABR03210.1}
NUCLEOTIDE SEQUENCE.
STRAIN=0.10FR96 {ECO:0000313|EMBL:ABR03210.1},
0.11FR97 {ECO:0000313|EMBL:ABR03211.1},
0.14GE00 {ECO:0000313|EMBL:ABR03213.1},
0.16GR98 {ECO:0000313|EMBL:ABR03214.1},
0.20IT00 {ECO:0000313|EMBL:ABR03216.1},
0.21IT95 {ECO:0000313|EMBL:ABR03217.1},
0.2BE96 {ECO:0000313|EMBL:ABR03219.1},
0.34PL96 {ECO:0000313|EMBL:ABR03220.1},
0.36PL98 {ECO:0000313|EMBL:ABR03222.1},
0.4BE99 {ECO:0000313|EMBL:ABR03228.1},
0.53SP96 {ECO:0000313|EMBL:ABR03230.1},
0.5CR96 {ECO:0000313|EMBL:ABR03234.1},
0.68Oh92 {ECO:0000313|EMBL:ABR03235.1},
0.71Oh93 {ECO:0000313|EMBL:ABR03238.1},
0.73Oh93 {ECO:0000313|EMBL:ABR03239.1},
0.7FR93 {ECO:0000313|EMBL:ABR03241.1},
0.92FR98 {ECO:0000313|EMBL:ABR03244.1},
0a {ECO:0000313|EMBL:ABR03246.1}, 0c {ECO:0000313|EMBL:ABR03247.1},
0f {ECO:0000313|EMBL:ABR03248.1},
275.1Oh93 {ECO:0000313|EMBL:ABR03256.1},
305.1Oh93 {ECO:0000313|EMBL:ABR03259.1},
320.1SP97 {ECO:0000313|EMBL:ABR03260.1},
380.5PR00 {ECO:0000313|EMBL:ABR03282.1},
393.2FR95 {ECO:0000313|EMBL:ABR03288.1},
415.1SP93 {ECO:0000313|EMBL:ABR03310.1},
439.1BE96 {ECO:0000313|EMBL:ABR03312.1},
440.1ZA99 {ECO:0000313|EMBL:ABR03313.1},
450.1Oh93 {ECO:0000313|EMBL:ABR03316.1},
464.1SP95 {ECO:0000313|EMBL:ABR03321.1},
486.1FR95 {ECO:0000313|EMBL:ABR03323.1},
498.1SP95 {ECO:0000313|EMBL:ABR03325.1},
498.3SP95 {ECO:0000313|EMBL:ABR03326.1},
500.1FR95 {ECO:0000313|EMBL:ABR03329.1},
518.1SP95 {ECO:0000313|EMBL:ABR03332.1},
520.1Oh00 {ECO:0000313|EMBL:ABR03333.1},
521a.1FR96 {ECO:0000313|EMBL:ABR03334.1},
533.1SP95 {ECO:0000313|EMBL:ABR03343.1},
535.1Oh94 {ECO:0000313|EMBL:ABR03344.1},
550.1CR96 {ECO:0000313|EMBL:ABR03346.1},
552.1FR95 {ECO:0000313|EMBL:ABR03347.1},
553.1FR95 {ECO:0000313|EMBL:ABR03348.1},
554.1SP95 {ECO:0000313|EMBL:ABR03350.1},
560.1JA98 {ECO:0000313|EMBL:ABR03351.1},
595.1FR00 {ECO:0000313|EMBL:ABR03357.1},
595.4IT95 {ECO:0000313|EMBL:ABR03359.1},
599.1FR95 {ECO:0000313|EMBL:ABR03363.1},
599.3FR95 {ECO:0000313|EMBL:ABR03364.1},
600.1CR96 {ECO:0000313|EMBL:ABR03366.1},
600.2CR96 {ECO:0000313|EMBL:ABR03367.1},
600.3CR96 {ECO:0000313|EMBL:ABR03368.1},
601.1FR95 {ECO:0000313|EMBL:ABR03369.1},
615.1Oh00 {ECO:0000313|EMBL:ABR03373.1},
615.5Oh00 {ECO:0000313|EMBL:ABR03375.1},
615.6Oh97 {ECO:0000313|EMBL:ABR03376.1},
630.1SP00 {ECO:0000313|EMBL:ABR03377.1},
635.1PL97 {ECO:0000313|EMBL:ABR03378.1},
643.1CH99 {ECO:0000313|EMBL:ABR03384.1},
645.1SL00 {ECO:0000313|EMBL:ABR03385.1},
645.2SL00 {ECO:0000313|EMBL:ABR03386.1},
645.7SP95 {ECO:0000313|EMBL:ABR03387.1},
645.8FR95 {ECO:0000313|EMBL:ABR03388.1},
645.9FR98 {ECO:0000313|EMBL:ABR03389.1},
650.1PL96 {ECO:0000313|EMBL:ABR03390.1},
651.1FR98 {ECO:0000313|EMBL:ABR03391.1},
660.1PL96 {ECO:0000313|EMBL:ABR03395.1},
670.4FR99 {ECO:0000313|EMBL:ABR03401.1},
670.7SL00 {ECO:0000313|EMBL:ABR03403.1},
674.1FR95 {ECO:0000313|EMBL:ABR03406.1},
674.3FR95 {ECO:0000313|EMBL:ABR03408.1},
675.1PL96 {ECO:0000313|EMBL:ABR03409.1},
675.2PL97 {ECO:0000313|EMBL:ABR03410.1},
685.4PL00 {ECO:0000313|EMBL:ABR03413.1},
685.6PL97 {ECO:0000313|EMBL:ABR03414.1},
685.7PL98 {ECO:0000313|EMBL:ABR03415.1},
688.1CH99 {ECO:0000313|EMBL:ABR03417.1},
705.2CH00 {ECO:0000313|EMBL:ABR03419.1},
705.3CH00 {ECO:0000313|EMBL:ABR03420.1},
705.4CH00 {ECO:0000313|EMBL:ABR03421.1},
720.1CH00 {ECO:0000313|EMBL:ABR03422.1},
720.5CH00 {ECO:0000313|EMBL:ABR03423.1}, and
90.1Oh00 {ECO:0000313|EMBL:ABR03425.1};
PubMed=17475572; DOI=10.1016/j.meegid.2007.03.004;
Stanhope M.J., Walsh S.L., Becker J.A., Miller L.A., Lefebure T.,
Lang P., Bitar P.D., Amrine-Madsen H.;
"The relative frequency of intraspecific lateral gene transfer of
penicillin binding proteins 1a, 2b, and 2x, in amoxicillin resistant
Streptococcus pneumoniae.";
Infect. Genet. Evol. 7:520-534(2007).
-!- FUNCTION: Converts the preformed base xanthine, a product of
nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so
it can be reused for RNA or DNA synthesis.
{ECO:0000256|SAAS:SAAS00756464}.
-!- CATALYTIC ACTIVITY: XMP + diphosphate = 5-phospho-alpha-D-ribose
1-diphosphate + xanthine. {ECO:0000256|SAAS:SAAS00756462}.
-!- PATHWAY: Purine metabolism; XMP biosynthesis via salvage pathway;
XMP from xanthine: step 1/1. {ECO:0000256|SAAS:SAAS00756456}.
-!- SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS00756451}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756467}.
-!- SIMILARITY: Belongs to the purine/pyrimidine
phosphoribosyltransferase family. Xpt subfamily.
{ECO:0000256|SAAS:SAAS00756458}.
-----------------------------------------------------------------------
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EMBL; EF500835; ABR03210.1; -; Genomic_DNA.
EMBL; EF500836; ABR03211.1; -; Genomic_DNA.
EMBL; EF500838; ABR03213.1; -; Genomic_DNA.
EMBL; EF500839; ABR03214.1; -; Genomic_DNA.
EMBL; EF500841; ABR03216.1; -; Genomic_DNA.
EMBL; EF500842; ABR03217.1; -; Genomic_DNA.
EMBL; EF500844; ABR03219.1; -; Genomic_DNA.
EMBL; EF500845; ABR03220.1; -; Genomic_DNA.
EMBL; EF500847; ABR03222.1; -; Genomic_DNA.
EMBL; EF500853; ABR03228.1; -; Genomic_DNA.
EMBL; EF500855; ABR03230.1; -; Genomic_DNA.
EMBL; EF500859; ABR03234.1; -; Genomic_DNA.
EMBL; EF500860; ABR03235.1; -; Genomic_DNA.
EMBL; EF500863; ABR03238.1; -; Genomic_DNA.
EMBL; EF500864; ABR03239.1; -; Genomic_DNA.
EMBL; EF500866; ABR03241.1; -; Genomic_DNA.
EMBL; EF500869; ABR03244.1; -; Genomic_DNA.
EMBL; EF500871; ABR03246.1; -; Genomic_DNA.
EMBL; EF500872; ABR03247.1; -; Genomic_DNA.
EMBL; EF500873; ABR03248.1; -; Genomic_DNA.
EMBL; EF500881; ABR03256.1; -; Genomic_DNA.
EMBL; EF500884; ABR03259.1; -; Genomic_DNA.
EMBL; EF500885; ABR03260.1; -; Genomic_DNA.
EMBL; EF500907; ABR03282.1; -; Genomic_DNA.
EMBL; EF500913; ABR03288.1; -; Genomic_DNA.
EMBL; EF500935; ABR03310.1; -; Genomic_DNA.
EMBL; EF500937; ABR03312.1; -; Genomic_DNA.
EMBL; EF500938; ABR03313.1; -; Genomic_DNA.
EMBL; EF500941; ABR03316.1; -; Genomic_DNA.
EMBL; EF500946; ABR03321.1; -; Genomic_DNA.
EMBL; EF500948; ABR03323.1; -; Genomic_DNA.
EMBL; EF500950; ABR03325.1; -; Genomic_DNA.
EMBL; EF500951; ABR03326.1; -; Genomic_DNA.
EMBL; EF500954; ABR03329.1; -; Genomic_DNA.
EMBL; EF500957; ABR03332.1; -; Genomic_DNA.
EMBL; EF500958; ABR03333.1; -; Genomic_DNA.
EMBL; EF500959; ABR03334.1; -; Genomic_DNA.
EMBL; EF500968; ABR03343.1; -; Genomic_DNA.
EMBL; EF500969; ABR03344.1; -; Genomic_DNA.
EMBL; EF500971; ABR03346.1; -; Genomic_DNA.
EMBL; EF500972; ABR03347.1; -; Genomic_DNA.
EMBL; EF500973; ABR03348.1; -; Genomic_DNA.
EMBL; EF500975; ABR03350.1; -; Genomic_DNA.
EMBL; EF500976; ABR03351.1; -; Genomic_DNA.
EMBL; EF500982; ABR03357.1; -; Genomic_DNA.
EMBL; EF500984; ABR03359.1; -; Genomic_DNA.
EMBL; EF500988; ABR03363.1; -; Genomic_DNA.
EMBL; EF500989; ABR03364.1; -; Genomic_DNA.
EMBL; EF500991; ABR03366.1; -; Genomic_DNA.
EMBL; EF500992; ABR03367.1; -; Genomic_DNA.
EMBL; EF500993; ABR03368.1; -; Genomic_DNA.
EMBL; EF500994; ABR03369.1; -; Genomic_DNA.
EMBL; EF500998; ABR03373.1; -; Genomic_DNA.
EMBL; EF501000; ABR03375.1; -; Genomic_DNA.
EMBL; EF501001; ABR03376.1; -; Genomic_DNA.
EMBL; EF501002; ABR03377.1; -; Genomic_DNA.
EMBL; EF501003; ABR03378.1; -; Genomic_DNA.
EMBL; EF501009; ABR03384.1; -; Genomic_DNA.
EMBL; EF501010; ABR03385.1; -; Genomic_DNA.
EMBL; EF501011; ABR03386.1; -; Genomic_DNA.
EMBL; EF501012; ABR03387.1; -; Genomic_DNA.
EMBL; EF501013; ABR03388.1; -; Genomic_DNA.
EMBL; EF501014; ABR03389.1; -; Genomic_DNA.
EMBL; EF501015; ABR03390.1; -; Genomic_DNA.
EMBL; EF501016; ABR03391.1; -; Genomic_DNA.
EMBL; EF501020; ABR03395.1; -; Genomic_DNA.
EMBL; EF501026; ABR03401.1; -; Genomic_DNA.
EMBL; EF501028; ABR03403.1; -; Genomic_DNA.
EMBL; EF501031; ABR03406.1; -; Genomic_DNA.
EMBL; EF501033; ABR03408.1; -; Genomic_DNA.
EMBL; EF501034; ABR03409.1; -; Genomic_DNA.
EMBL; EF501035; ABR03410.1; -; Genomic_DNA.
EMBL; EF501038; ABR03413.1; -; Genomic_DNA.
EMBL; EF501039; ABR03414.1; -; Genomic_DNA.
EMBL; EF501040; ABR03415.1; -; Genomic_DNA.
EMBL; EF501042; ABR03417.1; -; Genomic_DNA.
EMBL; EF501044; ABR03419.1; -; Genomic_DNA.
EMBL; EF501045; ABR03420.1; -; Genomic_DNA.
EMBL; EF501046; ABR03421.1; -; Genomic_DNA.
EMBL; EF501047; ABR03422.1; -; Genomic_DNA.
EMBL; EF501048; ABR03423.1; -; Genomic_DNA.
EMBL; EF501050; ABR03425.1; -; Genomic_DNA.
EMBL; AJ232399; CAA13402.1; -; Genomic_DNA.
EMBL; AJ232404; CAA13407.1; -; Genomic_DNA.
EMBL; AJ232412; CAA13415.1; -; Genomic_DNA.
EMBL; AJ232415; CAA13418.1; -; Genomic_DNA.
EMBL; AJ232419; CAA13422.1; -; Genomic_DNA.
EMBL; AJ232421; CAA13424.1; -; Genomic_DNA.
EMBL; AJ232423; CAA13426.1; -; Genomic_DNA.
EMBL; AJ232426; CAA13429.1; -; Genomic_DNA.
EMBL; AJ232431; CAA13434.1; -; Genomic_DNA.
EMBL; AJ252546; CAB60659.1; -; Genomic_DNA.
ProteinModelPortal; Q4U2N0; -.
eggNOG; ENOG4108UPS; Bacteria.
eggNOG; COG0503; LUCA.
UniPathway; UPA00602; UER00658.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0000310; F:xanthine phosphoribosyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
GO; GO:0046110; P:xanthine metabolic process; IEA:InterPro.
GO; GO:0032265; P:XMP salvage; IEA:UniProtKB-UniPathway.
CDD; cd06223; PRTases_typeI; 1.
InterPro; IPR000836; PRibTrfase_dom.
InterPro; IPR029057; PRTase-like.
InterPro; IPR010079; Xanthine_PRibTrfase.
PANTHER; PTHR43864:SF1; PTHR43864:SF1; 1.
Pfam; PF00156; Pribosyltran; 1.
SUPFAM; SSF53271; SSF53271; 1.
TIGRFAMs; TIGR01744; XPRTase; 1.
3: Inferred from homology;
Cytoplasm {ECO:0000256|SAAS:SAAS00756461};
Glycosyltransferase {ECO:0000256|SAAS:SAAS00756450,
ECO:0000313|EMBL:CAA13407.1};
Purine salvage {ECO:0000256|SAAS:SAAS00756453};
Transferase {ECO:0000256|SAAS:SAAS00756450,
ECO:0000313|EMBL:CAA13407.1}.
DOMAIN 21 139 Pribosyltran. {ECO:0000259|Pfam:PF00156}.
NON_TER 1 1 {ECO:0000313|EMBL:CAA13407.1}.
NON_TER 162 162 {ECO:0000313|EMBL:CAA13407.1}.
SEQUENCE 162 AA; 17333 MW; ABF067ED59ABBED9 CRC64;
GDNILKVDSF LTHQVDFSLM REIGKVFAEK FAATGITKVV TIEASGIAPA VFTAEALNVP
MIFAKKAKNI TMNEGILTAQ VYSFTKQVTS TVSIAGKFLS PEDKVLIIDD FLANGQAAKG
LIQIIEQAGA TVQAIGIVIE KSFQDGRDLL EKAGYPVLSL AR


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