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Zinc finger and SCAN domain-containing protein 12 (Zinc finger protein 305) (Zinc finger protein 96)

 ZSC12_HUMAN             Reviewed;         604 AA.
O43309; O43724;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
25-OCT-2017, entry version 150.
RecName: Full=Zinc finger and SCAN domain-containing protein 12;
AltName: Full=Zinc finger protein 305;
AltName: Full=Zinc finger protein 96;
Name=ZSCAN12; Synonyms=KIAA0426, ZNF305, ZNF96;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=9455477; DOI=10.1093/dnares/4.5.307;
Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N.,
Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. VIII.
78 new cDNA clones from brain which code for large proteins in
vitro.";
DNA Res. 4:307-313(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=14574404; DOI=10.1038/nature02055;
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-20; LYS-25 AND LYS-196, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=28112733; DOI=10.1038/nsmb.3366;
Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
Nielsen M.L.;
"Site-specific mapping of the human SUMO proteome reveals co-
modification with phosphorylation.";
Nat. Struct. Mol. Biol. 24:325-336(2017).
-!- FUNCTION: May be involved in transcriptional regulation.
-!- INTERACTION:
Q8NHQ1:CEP70; NbExp=3; IntAct=EBI-1210440, EBI-739624;
Q9UJV3-2:MID2; NbExp=5; IntAct=EBI-1210440, EBI-10172526;
Q5JR59:MTUS2; NbExp=3; IntAct=EBI-1210440, EBI-742948;
Q9Y2D8:SSX2IP; NbExp=3; IntAct=EBI-1210440, EBI-2212028;
Q9UBB9:TFIP11; NbExp=3; IntAct=EBI-1210440, EBI-1105213;
Q9P0L1:ZKSCAN7; NbExp=3; IntAct=EBI-1210440, EBI-743851;
Q9NWS9-2:ZNF446; NbExp=4; IntAct=EBI-1210440, EBI-740232;
Q8WTR7:ZNF473; NbExp=3; IntAct=EBI-1210440, EBI-751409;
Q96IT1:ZNF496; NbExp=3; IntAct=EBI-1210440, EBI-743906;
I3L3J2:ZSCAN32; NbExp=5; IntAct=EBI-1210440, EBI-10178206;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00187}.
-!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAA24856.2; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AB007886; BAA24856.2; ALT_INIT; mRNA.
EMBL; Z98745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC041661; AAH41661.1; -; mRNA.
UniGene; Hs.134816; -.
ProteinModelPortal; O43309; -.
SMR; O43309; -.
IntAct; O43309; 24.
STRING; 9606.ENSP00000354305; -.
iPTMnet; O43309; -.
PhosphoSitePlus; O43309; -.
EPD; O43309; -.
MaxQB; O43309; -.
PaxDb; O43309; -.
PeptideAtlas; O43309; -.
PRIDE; O43309; -.
Ensembl; ENST00000361028; ENSP00000354305; ENSG00000158691.
Ensembl; ENST00000396827; ENSP00000380039; ENSG00000158691.
UCSC; uc063mll.1; human.
EuPathDB; HostDB:ENSG00000158691.14; -.
GeneCards; ZSCAN12; -.
HGNC; HGNC:13172; ZSCAN12.
HPA; HPA006637; -.
MIM; 603978; gene.
neXtProt; NX_O43309; -.
OpenTargets; ENSG00000158691; -.
PharmGKB; PA37744; -.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00760000118881; -.
HOGENOM; HOG000234619; -.
HOVERGEN; HBG018163; -.
InParanoid; O43309; -.
OMA; SLIPEWQ; -.
OrthoDB; EOG091G02KC; -.
PhylomeDB; O43309; -.
TreeFam; TF338146; -.
PRO; PR:O43309; -.
Proteomes; UP000005640; Chromosome 6.
Bgee; ENSG00000158691; -.
CleanEx; HS_ZSCAN12; -.
ExpressionAtlas; O43309; baseline and differential.
Genevisible; O43309; HS.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR008916; Retrov_capsid_C.
InterPro; IPR003309; SCAN_dom.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
Pfam; PF02023; SCAN; 1.
SMART; SM00431; SCAN; 1.
SMART; SM00355; ZnF_C2H2; 10.
SUPFAM; SSF47353; SSF47353; 1.
SUPFAM; SSF57667; SSF57667; 6.
PROSITE; PS50804; SCAN_BOX; 1.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
1: Evidence at protein level;
Complete proteome; DNA-binding; Isopeptide bond; Metal-binding;
Nucleus; Reference proteome; Repeat; Transcription;
Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
CHAIN 1 604 Zinc finger and SCAN domain-containing
protein 12.
/FTId=PRO_0000047403.
DOMAIN 46 128 SCAN box. {ECO:0000255|PROSITE-
ProRule:PRU00187}.
ZN_FING 274 296 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 302 324 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 330 352 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 358 380 C2H2-type 4. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 386 408 C2H2-type 5. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 414 436 C2H2-type 6. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 442 463 C2H2-type 7. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 469 491 C2H2-type 8. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 497 519 C2H2-type 9. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 525 547 C2H2-type 10. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 553 578 C2H2-type 11; degenerate.
{ECO:0000255|PROSITE-ProRule:PRU00042}.
CROSSLNK 20 20 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000244|PubMed:28112733}.
CROSSLNK 25 25 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000244|PubMed:28112733}.
CROSSLNK 196 196 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000244|PubMed:28112733}.
SEQUENCE 604 AA; 70222 MW; 6A7F8ECB515A7A73 CRC64;
MASTWAIQAH MDQDEPLEVK IEEEKYTTRQ DWDLRKNNTH SREVFRQYFR QFCYQETSGP
REALSRLREL CHQWLRPETH TKEQILELLV LEQFLTILPE ELQAWVQEQH PESGEEVVTV
LEDLERELDE PGEQVSVHTG EQEMFLQETV RLRKEGEPSM SLQSMKAQPK YESPELESQQ
EQVLDVETGN EYGNLKQEVS EEMEPHGKTS SKFENDMSKS ARCGETREPE EITEEPSACS
REDKQPTCDE NGVSLTENSD HTEHQRICPG EESYGCDDCG KAFSQHSHLI EHQRIHTGDR
PYKCEECGKA FRGRTVLIRH KIIHTGEKPY KCNECGKAFG RWSALNQHQR LHTGEKHYHC
NDCGKAFSQK AGLFHHIKIH TRDKPYQCTQ CNKSFSRRSI LTQHQGVHTG AKPYECNECG
KAFVYNSSLV SHQEIHHKEK CYQCKECGKS FSQSGLIQHQ RIHTGEKPYK CDVCEKAFIQ
RTSLTEHQRI HTGERPYKCD KCGKAFTQRS VLTEHQRIHT GERPYKCDEC GNAFRGITSL
IQHQRIHTGE KPYQCDECGK AFRQRKKTSY KEILLKNHSE PQAGVNLLLS SLIPEWQSCF
RRDL


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