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Zinc finger protein 143 (Selenocysteine tRNA gene transcription-activating factor)

 ZN143_XENLA             Reviewed;         565 AA.
Q91853; Q6IR49;
05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
05-MAY-2009, sequence version 2.
25-OCT-2017, entry version 80.
RecName: Full=Zinc finger protein 143;
AltName: Full=Selenocysteine tRNA gene transcription-activating factor;
Name=znf143; Synonyms=staf;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND DNA-BINDING.
TISSUE=Ovary;
PubMed=7641696;
Schuster C., Myslinski E., Krol A., Carbon P.;
"Staf, a novel zinc finger protein that activates the RNA polymerase
III promoter of the selenocysteine tRNA gene.";
EMBO J. 14:3777-3787(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Oocyte;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Transcriptional activator. Activates the gene for
selenocysteine tRNA (tRNAsec). Binds to the activator element (AE)
motif of the selenocysteine tRNA gene promoter.
{ECO:0000269|PubMed:7641696}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q91853-1; Sequence=Displayed;
Name=2;
IsoId=Q91853-2; Sequence=VSP_036981;
-!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH71051.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=CAA59354.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; X84996; CAA59354.1; ALT_INIT; mRNA.
EMBL; BC071051; AAH71051.1; ALT_INIT; mRNA.
PIR; S58681; S58681.
RefSeq; NP_001084373.1; NM_001090904.1.
RefSeq; XP_018115027.1; XM_018259538.1. [Q91853-2]
UniGene; Xl.23822; -.
SMR; Q91853; -.
GeneID; 399467; -.
KEGG; xla:399467; -.
CTD; 399467; -.
Xenbase; XB-GENE-1012509; znf143.
KO; K20828; -.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
SMART; SM00355; ZnF_C2H2; 7.
SUPFAM; SSF57667; SSF57667; 3.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
1: Evidence at protein level;
Activator; Alternative splicing; DNA-binding; Metal-binding; Nucleus;
Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 565 Zinc finger protein 143.
/FTId=PRO_0000370719.
ZN_FING 230 254 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 260 284 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 290 314 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 320 344 C2H2-type 4. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 350 374 C2H2-type 5. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 380 404 C2H2-type 6. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 410 433 C2H2-type 7. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
VAR_SEQ 493 538 Missing (in isoform 2).
{ECO:0000303|Ref.2}.
/FTId=VSP_036981.
SEQUENCE 565 AA; 61418 MW; F83B5A070E2A0387 CRC64;
MLLAQINRDS QAMAEFPGGG GEAQHVTLCL TEAVADGESM DTMEGMSLQA VTLADGSTAY
IQHNTKDGKL IEGQVIQLED GSAAYVQHVP KGDDLSLEDG QAVQLEDGTT AYIHHSSKDS
YDQSSVQAVQ LEDGTTAYIH HAVQVPQSDT ILAIQADGTV AGLHTGEASI DPDTISALEQ
YAAKVSIEGG EGAGSNALIN ESESEKKMQI VLSHGARLPI KAQQTNEKAF RCDYEGCGKL
YTTAHHLKVH ERSHTGDRPY QCDHGSCRKA FATGYGLKSH VRTHTGEKPY RCSEENCTKS
FKTSGDLQKH VRTHTGERPF KCPFEGCGRS FTTSNIRKVH IRTHTGERPY YCSEPGCGRA
FASATNYKNH VRIHTGEKPY VCTVPGCDKR FTEYSSLYKH HVVHTHSKPY NCNHCGKTYK
QISTLAMHKR TAHNDTEPIE EDQESFFVPQ PPDEVIKGSQ ITYVTGVDGE DGISATQSGQ
QLALIAQDGT SHVAIVAQDL SAFHNSETGP QHSHNLGGSD SRPVTLLATS NGRQIAVQIG
EQQSLEEAIR IASRIQQGES PGMED


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