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Zinc finger protein 22 (Zinc finger protein 422) (Zinc finger protein Krox-25) (Zinc finger protein Krox-26)

 ZNF22_MOUSE             Reviewed;         237 AA.
Q9ERU3; Q3TF83; Q8VEK7;
15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
15-MAR-2004, sequence version 2.
05-DEC-2018, entry version 137.
RecName: Full=Zinc finger protein 22;
AltName: Full=Zinc finger protein 422;
AltName: Full=Zinc finger protein Krox-25;
AltName: Full=Zinc finger protein Krox-26;
Name=Znf22; Synonyms=Krox25, Krox26, Zfp422;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000312|EMBL:AAG12466.1};
[1] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=BALB/cJ {ECO:0000312|EMBL:AAG12466.1};
TISSUE=Craniofacial {ECO:0000269|PubMed:14706453};
PubMed=14706453; DOI=10.1016/j.ygeno.2003.08.006;
Lee S.K., Kim Y.S., Lee S.S., Lee Y.J., Song I.S., Park S.C.,
Kozak C., Yamada Y.;
"Molecular cloning, chromosomal mapping, and characteristic expression
in tooth organ of rat and mouse Krox-25.";
Genomics 83:243-253(2004).
[2] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
STAGE.
PubMed=12489153; DOI=10.1080/03008200290001212;
Ganss B., Teo W., Chen H., Poon T.;
"Krox-26 is a novel C2H2 zinc finger transcription factor expressed in
developing dental and osteogenic tissues.";
Connect. Tissue Res. 43:161-166(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Kidney, and Spinal cord;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4] {ECO:0000305}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary gland {ECO:0000269|PubMed:15489334};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5] {ECO:0000305}
DNA-BINDING, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=12952191; DOI=10.1080/713713594;
Teo W., Chen H., Poon T., Ganss B.;
"Developmental expression pattern and DNA-binding properties of the
zinc finger transcription factor Krox-26.";
Connect. Tissue Res. 44:161-166(2003).
[6]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-18 AND LYS-23, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic fibroblast;
PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z.,
Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic
pathways.";
Mol. Cell 50:919-930(2013).
-!- FUNCTION: Binds DNA through the consensus sequence 5'-CAATG-3'.
May be involved in transcriptional regulation and may play a role
in tooth formation. {ECO:0000269|PubMed:12952191,
ECO:0000303|PubMed:12489153}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed predominantly in developing
craniofacial bones and dental organs, and in molar tooth germs of
postnatal animals. Also detected in embryonic heart, liver,
thymus, kidney, brain, lung, muscle and calvaria. In the adult,
highly expressed in lung, kidney, bone and incisors.
{ECO:0000269|PubMed:12489153, ECO:0000269|PubMed:12952191,
ECO:0000269|PubMed:14706453}.
-!- DEVELOPMENTAL STAGE: In the embryo, expression is detected from
day 7 with highest levels between days 11 and 15.
{ECO:0000269|PubMed:12489153, ECO:0000269|PubMed:12952191}.
-!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAG12466.1; Type=Frameshift; Positions=224; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AF281634; AAG12466.1; ALT_FRAME; mRNA.
EMBL; AK082970; BAC38716.1; -; mRNA.
EMBL; AK169251; BAE41015.1; -; mRNA.
EMBL; BC018339; AAH18339.1; -; mRNA.
CCDS; CCDS20459.1; -.
RefSeq; NP_001289368.1; NM_001302439.1.
RefSeq; NP_001289369.1; NM_001302440.1.
RefSeq; NP_080333.1; NM_026057.3.
UniGene; Mm.18810; -.
UniGene; Mm.465923; -.
ProteinModelPortal; Q9ERU3; -.
SMR; Q9ERU3; -.
BioGrid; 212050; 1.
IntAct; Q9ERU3; 1.
MINT; Q9ERU3; -.
STRING; 10090.ENSMUSP00000078685; -.
iPTMnet; Q9ERU3; -.
PhosphoSitePlus; Q9ERU3; -.
EPD; Q9ERU3; -.
MaxQB; Q9ERU3; -.
PaxDb; Q9ERU3; -.
PRIDE; Q9ERU3; -.
Ensembl; ENSMUST00000057540; ENSMUSP00000084926; ENSMUSG00000059878.
Ensembl; ENSMUST00000079749; ENSMUSP00000078685; ENSMUSG00000059878.
Ensembl; ENSMUST00000112880; ENSMUSP00000108501; ENSMUSG00000059878.
GeneID; 67255; -.
KEGG; mmu:67255; -.
UCSC; uc009dkj.1; mouse.
CTD; 67255; -.
MGI; MGI:1914505; Zfp422.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00940000153543; -.
HOGENOM; HOG000234617; -.
HOVERGEN; HBG018163; -.
InParanoid; Q9ERU3; -.
OMA; THLVSSW; -.
OrthoDB; EOG091G0I4B; -.
PhylomeDB; Q9ERU3; -.
TreeFam; TF350836; -.
PRO; PR:Q9ERU3; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000059878; Expressed in 293 organ(s), highest expression level in urinary bladder.
CleanEx; MM_ZFP422; -.
Genevisible; Q9ERU3; MM.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0001077; F:proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
GO; GO:0042476; P:odontogenesis; NAS:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
Pfam; PF00096; zf-C2H2; 5.
SMART; SM00355; ZnF_C2H2; 5.
SUPFAM; SSF57667; SSF57667; 3.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
1: Evidence at protein level;
Acetylation; Complete proteome; DNA-binding; Metal-binding; Nucleus;
Reference proteome; Repeat; Transcription; Transcription regulation;
Zinc; Zinc-finger.
CHAIN 1 237 Zinc finger protein 22.
/FTId=PRO_0000047349.
ZN_FING 55 77 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042, ECO:0000305}.
ZN_FING 83 105 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042, ECO:0000305}.
ZN_FING 111 133 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042, ECO:0000305}.
ZN_FING 139 161 C2H2-type 4. {ECO:0000255|PROSITE-
ProRule:PRU00042, ECO:0000305}.
ZN_FING 167 189 C2H2-type 5. {ECO:0000255|PROSITE-
ProRule:PRU00042, ECO:0000305}.
MOD_RES 18 18 N6-acetyllysine.
{ECO:0000244|PubMed:23806337}.
MOD_RES 23 23 N6-acetyllysine.
{ECO:0000244|PubMed:23806337}.
CONFLICT 192 192 K -> N (in Ref. 1; AAG12466).
{ECO:0000305}.
CONFLICT 216 216 R -> K (in Ref. 1 and 2). {ECO:0000305}.
CONFLICT 224 224 Q -> R (in Ref. 1 and 2). {ECO:0000305}.
CONFLICT 225 237 Missing (in Ref. 2). {ECO:0000305}.
SEQUENCE 237 AA; 27294 MW; 1653220411F3C7DD CRC64;
MRLGKPKGGI SRSASQGKAY ESKRKTARQR QKWGVAIRFD SGLSRRRRNV DEKPYKCAKC
SKSFSQSSTL FQHKKIHTGK KSHKCADCGK SFFQSSNLIQ HRRIHTGEKP YKCDECGERF
KQSSNLIQHQ RIHTGEKPYC CDECGRCFSQ SSHLIQHQRT HTGEKPYQCE ECDKCFSQSS
HLRQHMKVHK EKKPHKRGKN ARVKTHPVSW KRGKGRKAVA GIRQVKGATS GLFKKKK


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