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Zinc finger protein GLIS1 (GLI-similar 1) (Gli homologous protein 1) (GliH1)

 GLIS1_MOUSE             Reviewed;         789 AA.
Q8K1M4; Q6NZF6; Q8R4Z3;
21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 2.
10-MAY-2017, entry version 115.
RecName: Full=Zinc finger protein GLIS1;
AltName: Full=GLI-similar 1;
AltName: Full=Gli homologous protein 1;
Short=GliH1;
Name=Glis1 {ECO:0000312|MGI:MGI:2386723}; Synonyms=Gli5;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1] {ECO:0000305, ECO:0000312|EMBL:AAM93156.1}
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR
LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
STRAIN=BALB/cJ {ECO:0000312|EMBL:AAM93156.1};
TISSUE=Kidney {ECO:0000269|PubMed:12042312};
PubMed=12042312; DOI=10.1074/jbc.M203563200;
Kim Y.-S., Lewandoski M., Perantoni A.O., Kurebayashi S.,
Nakanishi G., Jetten A.M.;
"Identification of Glis1, a novel Gli-related, Kruppel-like zinc
finger protein containing transactivation and repressor functions.";
J. Biol. Chem. 277:30901-30913(2002).
[2] {ECO:0000305, ECO:0000312|EMBL:AAM12150.1}
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY,
AND DEVELOPMENTAL STAGE.
PubMed=12385751; DOI=10.1016/S0925-4773(02)00291-5;
Nakashima M., Tanese N., Ito M., Auerbach W., Bai C., Furukawa T.,
Toyono T., Akamine A., Joyner A.L.;
"A novel gene, GliH1, with homology to the Gli zinc finger domain not
required for mouse development.";
Mech. Dev. 119:21-34(2002).
[3] {ECO:0000305, ECO:0000312|EMBL:AAH66157.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-789 (ISOFORM 1).
STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH66157.1};
TISSUE=Kidney {ECO:0000312|EMBL:AAH66157.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Acts as both a repressor and activator of transcription.
Binds to the consensus sequence 5'-GACCACCCAC-3'.
{ECO:0000269|PubMed:12042312, ECO:0000269|PubMed:12385751}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12042312}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1 {ECO:0000269|PubMed:12042312};
IsoId=Q8K1M4-1; Sequence=Displayed;
Name=2 {ECO:0000269|PubMed:12385751};
IsoId=Q8K1M4-2; Sequence=VSP_051623;
-!- TISSUE SPECIFICITY: In the adult, expressed highly in placenta and
kidney and at lower levels in the testis, brain, colon, brown fat
tissue and thymus. During embryo development, expressed in the
frontal nasal region, branchial arches, somites, vibrissal and
hair follicles, limb buds, craniofacial regions, ventral part of
the tail, intervertebral disks, teeth, eyes and kidney.
{ECO:0000269|PubMed:12042312, ECO:0000269|PubMed:12385751}.
-!- DEVELOPMENTAL STAGE: In the embryo, expression is detected at 10
dpc becoming stronger by 11 dpc and continuing through to 16.5
dpc. {ECO:0000269|PubMed:12042312, ECO:0000269|PubMed:12385751}.
-!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH66157.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AF486579; AAM93156.1; -; mRNA.
EMBL; AF220434; AAM12150.1; -; mRNA.
EMBL; BC066157; AAH66157.1; ALT_INIT; mRNA.
CCDS; CCDS38831.1; -. [Q8K1M4-1]
RefSeq; NP_671754.2; NM_147221.2. [Q8K1M4-1]
RefSeq; XP_006503036.1; XM_006502973.3. [Q8K1M4-1]
RefSeq; XP_006503037.1; XM_006502974.3. [Q8K1M4-1]
RefSeq; XP_006503038.1; XM_006502975.1. [Q8K1M4-1]
UniGene; Mm.331757; -.
ProteinModelPortal; Q8K1M4; -.
SMR; Q8K1M4; -.
STRING; 10090.ENSMUSP00000035650; -.
iPTMnet; Q8K1M4; -.
PhosphoSitePlus; Q8K1M4; -.
PaxDb; Q8K1M4; -.
PRIDE; Q8K1M4; -.
Ensembl; ENSMUST00000046005; ENSMUSP00000035650; ENSMUSG00000034762. [Q8K1M4-1]
GeneID; 230587; -.
KEGG; mmu:230587; -.
UCSC; uc008tzv.1; mouse. [Q8K1M4-1]
CTD; 148979; -.
MGI; MGI:2386723; Glis1.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00760000118771; -.
HOGENOM; HOG000231136; -.
HOVERGEN; HBG051736; -.
InParanoid; Q8K1M4; -.
KO; K09232; -.
OMA; LRPNGYH; -.
OrthoDB; EOG091G0IZP; -.
PhylomeDB; Q8K1M4; -.
TreeFam; TF350216; -.
ChiTaRS; Glis1; mouse.
PRO; PR:Q8K1M4; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000034762; -.
CleanEx; MM_GLIS1; -.
ExpressionAtlas; Q8K1M4; baseline and differential.
Genevisible; Q8K1M4; MM.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; IDA:NTNU_SB.
GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding; IDA:NTNU_SB.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:NTNU_SB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI.
InterPro; IPR030430; GLIS1.
InterPro; IPR013087; Znf_C2H2_type.
PANTHER; PTHR19818:SF97; PTHR19818:SF97; 1.
SMART; SM00355; ZnF_C2H2; 5.
SUPFAM; SSF57667; SSF57667; 3.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
2: Evidence at transcript level;
Activator; Alternative splicing; Complete proteome; DNA-binding;
Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
Transcription; Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 789 Zinc finger protein GLIS1.
/FTId=PRO_0000047210.
ZN_FING 366 391 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 400 427 C2H2-type 2; atypical.
{ECO:0000255|PROSITE-ProRule:PRU00042}.
ZN_FING 433 457 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 463 487 C2H2-type 4. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 493 517 C2H2-type 5. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
MOTIF 511 527 Bipartite nuclear localization signal.
{ECO:0000255}.
COMPBIAS 627 680 Pro-rich.
VAR_SEQ 1 171 Missing (in isoform 2).
{ECO:0000303|PubMed:12385751}.
/FTId=VSP_051623.
CONFLICT 173 173 V -> A (in Ref. 1; AAM93156).
{ECO:0000305}.
CONFLICT 354 354 G -> R (in Ref. 1; AAM93156).
{ECO:0000305}.
CONFLICT 378 378 E -> G (in Ref. 3; AAH66157).
{ECO:0000305}.
CONFLICT 384 384 V -> E (in Ref. 3; AAH66157).
{ECO:0000305}.
CONFLICT 466 466 Q -> R (in Ref. 1; AAM93156).
{ECO:0000305}.
CONFLICT 634 634 V -> A (in Ref. 3; AAH66157).
{ECO:0000305}.
CONFLICT 668 668 Y -> S (in Ref. 3; AAH66157).
{ECO:0000305}.
SEQUENCE 789 AA; 84172 MW; 98D87D9EA20D38FD CRC64;
MHCEVAEALS DKRPKEAPGA PGQGRGPVSL GAHMAFRIAV SGGGCGDGNP LDLLPRLPVP
PPRAHDLLRP RSPRDYGVSK TGSGKVNGSY GHSSEKSLLD LDLAEGPSPS CHQGLFLPAG
TPPPRGHPPV CEKLLHFPHP NRSPRPQATF VNGSLPAAQH IKQEALPDYQ AMVSAHTPLP
THCRAPSSMG LPSDLDFPDR GLTNPAPSCY LLGNEPISDL GPQPEAHLPE GSLKRCCLLG
LPPTSSASSS PCASSDINPV IHSSQTALVS CVNGLRSPPL PGDLGGPPKR SRPGPASSDG
QEGSLQLEAC RKSGFLKQEP MDEFSELFAP HHQGLPPPYP LPQLPTGPGL GGLGLGLAGR
MVAGRQACRW VDCCAAYEQQ EELVRHIEKS HIDQRKGEDF TCFWAGCVRR YKPFNARYKL
LIHMRVHSGE KPNKCMFEGC SKAFSRLENL KIHLRSHTGE KPYLCQHPGC QKAFSNSSDR
AKHQRTHLDT KPYACQIPGC SKRYTDPSSL RKHVKAHSAK EQQVRKKLHT GADPEADVLS
ECLSLQQLQA STLLPASRGK GSQTLSQELL PGVYPGSVTP QNGLASGILS PSHDVPSRHH
PLEVPTGSHH HLSPLPTAES TRDGLGPSLL SPMVSPLKGL GPPPLPPASQ SQSPGGQSFS
TVPSKPTYPS FQSPPPLPSP QGYQGSFHSI QNCFPYADCY RATEPAASRD GLVGDAHGFN
PLRPSTYSSL STPLSAPGYE TLAETPCPPA LQPQPAEDLV PSGPEDCGFF PNGAFDHCLS
HIPSIYTDT


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