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Zinc finger protein ZFAT (Zinc finger protein 406)

 ZFAT_MOUSE              Reviewed;        1237 AA.
Q7TS63; B2C322;
10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
22-JUL-2008, sequence version 2.
25-OCT-2017, entry version 122.
RecName: Full=Zinc finger protein ZFAT;
AltName: Full=Zinc finger protein 406;
Name=Zfat; Synonyms=Gm922, Zfat1, Zfp406, Znf406;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR
LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
STRAIN=C57BL/6J;
PubMed=18329245; DOI=10.1016/j.ygeno.2008.01.009;
Koyanagi M., Nakabayashi K., Fujimoto T., Gu N., Baba I.,
Takashima Y., Doi K., Harada H., Kato N., Sasazuki T., Shirasawa S.;
"ZFAT expression in B and T lymphocytes and identification of ZFAT-
regulated genes.";
Genomics 91:451-457(2008).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Olfactory epithelium;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
STRUCTURE BY NMR OF 345-374 AND 451-478.
RIKEN structural genomics initiative (RSGI);
Submitted (MAR-2007) to the PDB data bank.
-!- FUNCTION: May be involved in transcriptional regulation.
Overexpression causes down-regulation of a number of genes
involved in the immune response. Some genes are also up-regulated.
{ECO:0000269|PubMed:18329245}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18329245}.
Cytoplasm, cytosol {ECO:0000269|PubMed:18329245}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q7TS63-1; Sequence=Displayed;
Name=2;
IsoId=Q7TS63-2; Sequence=VSP_034940, VSP_034941;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Detected in spleen and thymus but not in
liver, muscle, heart, kidney, brain, bone marrow or pancreas.
Expressed in CD19+, CD4+ and CD8+ lymphocytes but not in CD11b+
lymphocytes or peritoneal macrophages (at protein level).
{ECO:0000269|PubMed:18329245}.
-!- DEVELOPMENTAL STAGE: Up-regulated during the transition from
CD4-/CD8- to CD4+/CD8+ thymocytes. {ECO:0000269|PubMed:18329245}.
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EMBL; EU221277; ABY67968.1; -; mRNA.
EMBL; BC053930; AAH53930.1; -; mRNA.
CCDS; CCDS49623.1; -. [Q7TS63-1]
CCDS; CCDS49624.1; -. [Q7TS63-2]
RefSeq; NP_001139360.1; NM_001145888.1. [Q7TS63-1]
RefSeq; NP_941046.1; NM_198644.2. [Q7TS63-2]
UniGene; Mm.309526; -.
PDB; 2ELW; NMR; -; A=352-381.
PDB; 2ELX; NMR; -; A=458-485.
PDB; 2RV4; NMR; -; A=352-381.
PDB; 2RV5; NMR; -; A=458-485.
PDBsum; 2ELW; -.
PDBsum; 2ELX; -.
PDBsum; 2RV4; -.
PDBsum; 2RV5; -.
ProteinModelPortal; Q7TS63; -.
SMR; Q7TS63; -.
STRING; 10090.ENSMUSP00000125257; -.
iPTMnet; Q7TS63; -.
PhosphoSitePlus; Q7TS63; -.
PaxDb; Q7TS63; -.
PRIDE; Q7TS63; -.
Ensembl; ENSMUST00000160248; ENSMUSP00000125257; ENSMUSG00000022335. [Q7TS63-1]
Ensembl; ENSMUST00000162054; ENSMUSP00000125732; ENSMUSG00000022335. [Q7TS63-2]
GeneID; 380993; -.
KEGG; mmu:380993; -.
UCSC; uc007wbd.2; mouse. [Q7TS63-2]
UCSC; uc011zto.1; mouse. [Q7TS63-1]
CTD; 57623; -.
MGI; MGI:2681865; Zfat.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00890000139444; -.
HOGENOM; HOG000155776; -.
HOVERGEN; HBG065928; -.
InParanoid; Q7TS63; -.
OMA; CKKKYSD; -.
OrthoDB; EOG091G00PE; -.
PhylomeDB; Q7TS63; -.
TreeFam; TF350017; -.
EvolutionaryTrace; Q7TS63; -.
PRO; PR:Q7TS63; -.
Proteomes; UP000000589; Chromosome 15.
Bgee; ENSMUSG00000022335; -.
CleanEx; MM_ZFAT; -.
ExpressionAtlas; Q7TS63; baseline and differential.
Genevisible; Q7TS63; MM.
GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IC:MGI.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:MGI.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
GO; GO:0030097; P:hemopoiesis; IMP:MGI.
GO; GO:0060712; P:spongiotrophoblast layer development; IMP:MGI.
Gene3D; 3.30.40.10; -; 1.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
SMART; SM00355; ZnF_C2H2; 19.
SUPFAM; SSF57667; SSF57667; 8.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
1: Evidence at protein level;
3D-structure; Alternative splicing; Complete proteome; Cytoplasm;
DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
Transcription; Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 1237 Zinc finger protein ZFAT.
/FTId=PRO_0000047567.
ZN_FING 12 35 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 116 141 C2H2-type 2; degenerate.
{ECO:0000255|PROSITE-ProRule:PRU00042}.
ZN_FING 271 293 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 299 321 C2H2-type 4. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 326 349 C2H2-type 5. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 354 377 C2H2-type 6. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 404 426 C2H2-type 7. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 432 454 C2H2-type 8. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 458 481 C2H2-type 9. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 737 759 C2H2-type 10. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 765 788 C2H2-type 11. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 793 817 C2H2-type 12. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 825 848 C2H2-type 13. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 875 898 C2H2-type 14; degenerate.
{ECO:0000255|PROSITE-ProRule:PRU00042}.
ZN_FING 904 926 C2H2-type 15. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 932 954 C2H2-type 16. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 961 983 C2H2-type 17. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 989 1012 C2H2-type 18. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 1036 1059 C2H2-type 19. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
VAR_SEQ 144 150 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_034940.
VAR_SEQ 1063 1073 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_034941.
STRAND 357 359 {ECO:0000244|PDB:2ELW}.
STRAND 362 365 {ECO:0000244|PDB:2RV4}.
HELIX 366 376 {ECO:0000244|PDB:2ELW}.
STRAND 461 463 {ECO:0000244|PDB:2ELX}.
STRAND 466 469 {ECO:0000244|PDB:2ELX}.
HELIX 470 479 {ECO:0000244|PDB:2ELX}.
SEQUENCE 1237 AA; 137883 MW; 085176A902B319E9 CRC64;
METRTAENTA IFMCKCCNLF SPNQSELVTH VSEKHGEEGV NVDDVIIPLR PLNTPENPNP
SKGGDEFLVM KRKRGRPKGS TKKPSTEEEV VENLVSPSED GPLATEEGSR LAPSSLECSK
CCRKFSNTRQ LRKHICIIVL NLGEEDGDAG NESDLDLEKT YKEDDREKAS KRPRAQKTEK
VQKISGKEAG QLSGAKKPII SVVLTAHEAI PGATKIIPVE AGPPETGAPP PETTAADLVP
RRGYQEYAIQ QTPYEQPMKS SRLGPTQLKI FTCEYCNKVF KFKHSLQAHL RIHTNEKPYK
CSQCSYASAI KANLNVHLRK HTGEKFACDY CSFTCLSKGH LKVHIERVHK KIKQHCRFCK
KKYSDVKNLI KHIRDMHDPQ DKKVKEALDE LRLMTREGKR QLLYDCHICE RKFKNELDRD
RHMLVHGDKW PFACELCGHG ATKYQALELH VRKHPFVYVC ALCLKKFVSS IRLRSHIREV
HGAAQETLVF TSSINQSFCL LEPGGDIQQE ALGDQLQLAA EEFVCPEIDV RKEEACPGEA
QPEVGLRELV VPGDAHAPPP GPLATPQSES SSLSPCKLET TVVSSDLNSL GVVSDDFLLK
SDTSSAEPPA AAEATSDTQH RDSAQTQGEE VTLLLAKAKS AGPDPESSPG GRQKVGALPA
SESDSSTCLR ANPTEASDLL PTVTDGGDLG VCQPDSCTPS SEHHPGSTAF MKVLDSLQKK
QMNTSLCERI RKVYGDLECE YCGKLFWYQV HFDMHVRTHT REHLYYCSQC HYSSITKNCL
KRHVIQKHSN ILLKCPTDGC DYSTPDKYKL QAHLKVHTEL DKRSYSCPVC EKSFSEDRLI
KSHIKTNHPE VSMNTISEVL GRRVQLKGLI GKRAMKCPYC DFYFMKNGSD LQRHIWAHEG
VKPFKCSLCE YATRSKSNLK AHMNRHSTEK THLCDMCGKK FKSKGTLKSH KLLHTSDGKQ
FKCTVCDYTA AQKPQLLRHM EQHASFKPFR CAHCHYSCNI SGSLKRHYNR KHPNEEYTNV
GSGELAAEAL IQQGGLKCPV CSFVYGTKWE FNRHLKNKHG LKVVEIDGDP KWEPAAETPE
EPSTQYLYIT EAEDVQGTQA AVAALQDLRY TSESGDRLDP TAVNILQQII ELGSETHDAA
AVASVVAMAP GTVTVVKQVT DEEPSSNHTV MIQETLQQAS VELAEQHHLV VSSDDVEGIE
TVTVYTQGGE ASEFIVYVQE AVQPVEEQVG EQPAPEL


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