Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom metalloproteinase brevilysin L4 (SVMP) (Snake venom metalloproteinase hxl-1) (EC 3.4.24.-); Disintegrin brevicaudin-1a; Disintegrin brevicaudin-1b (Disintegrin adinbitor) (Disintegrin halystatin)] (Fragment)

 VM2L4_GLOBR             Reviewed;         319 AA.
Q698K8;
05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
13-NOV-2013, sequence version 3.
12-SEP-2018, entry version 61.
RecName: Full=Zinc metalloproteinase/disintegrin;
Contains:
RecName: Full=Snake venom metalloproteinase brevilysin L4;
Short=SVMP;
AltName: Full=Snake venom metalloproteinase hxl-1;
EC=3.4.24.-;
Contains:
RecName: Full=Disintegrin brevicaudin-1a;
Contains:
RecName: Full=Disintegrin brevicaudin-1b;
AltName: Full=Disintegrin adinbitor;
AltName: Full=Disintegrin halystatin;
Flags: Precursor; Fragment;
Gloydius brevicaudus (Korean slamosa snake) (Agkistrodon halys
brevicaudus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Gloydius.
NCBI_TaxID=259325;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 29-237, MASS
SPECTROMETRY, AND 3D-STRUCTURE MODELING.
TISSUE=Venom, and Venom gland;
PubMed=15777952; DOI=10.1016/j.toxicon.2004.12.005;
Deshimaru M., Ichihara M., Hattori T., Koba K., Terada S.;
"Primary structure of brevilysin L4, an enzymatically active fragment
of a disintegrin precursor from Gloydius halys brevicaudus venom.";
Toxicon 45:571-580(2005).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 244-319, FUNCTION, AND ACTIVITY
REGULATION.
TISSUE=Venom gland;
PubMed=15188058; DOI=10.1093/abbs/36.6.425;
Wang J.-H., Wu Y., Ren F., Lu L., Zhao B.-C.;
"Cloning and characterization of adinbitor, a novel disintegrin from
the snake venom of Agkistrodon halys brevicaudus stejneger.";
Acta Biochim. Biophys. Sin. 36:425-429(2004).
[3]
PROTEIN SEQUENCE OF 247-319, AND FUNCTION.
TISSUE=Venom;
Oshikawa K., Yasukouchi Y., Terada S.;
"Isolation and primary structures of platelet aggregation inhibitors
from Gloydius halys brevicaudus venom.";
Fukuoka Univ. Sci. Rep. 30:201-208(2000).
-!- FUNCTION: Snake venom metalloproteinase brevilysin L4:
metalloproteinase that impairs hemostasis in the envenomed animal
(By similarity). Shows autoproteolysis dependent on pH and
temperature. Does not show hemorrhagic activity. {ECO:0000250,
ECO:0000269|PubMed:15188058, ECO:0000269|Ref.3}.
-!- FUNCTION: Disintegrin brevicaudin-1a: inhibits platelet
aggregation induced by ADP (IC(50) is 200 nM), collagen (IC(50) is
500 nM), thrombin and epinephrin (IC(50) is 300 nM). Does not
inhibit aggregation induced by ristocetin.
-!- FUNCTION: Disintegrin brevicaudin-1b: inhibits platelet
aggregation induced by ADP (IC(50) is 100 nM), collagen (IC(50) is
500 nM), thrombin and epinephrin (IC(50) is 300 nM). Does not
inhibit aggregation induced by ristocetin. Significantly inhibits
angiogenesis both in vivo and in vitro.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
Note=Binds 1 zinc ion per subunit. {ECO:0000250};
-!- ACTIVITY REGULATION: Excess of calcium ions significantly suppress
the autoproteolysis of the enzyme. {ECO:0000269|PubMed:15188058}.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- MASS SPECTROMETRY: Mass=22752; Method=MALDI; Range=29-230;
Evidence={ECO:0000269|PubMed:15777952};
-!- MISCELLANEOUS: The disintegrins belong to the medium disintegrin
subfamily.
-!- SIMILARITY: Belongs to the venom metalloproteinase (M12B) family.
P-II subfamily. P-IIa sub-subfamily. {ECO:0000305}.
-!- CAUTION: The metalloprotease is also encoded by another precursor
(AC Q90WC0). {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAT76292.1; Type=Erroneous termination; Positions=320; Note=Translated as stop.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AY551929; AAT76292.1; ALT_TERM; mRNA.
PIR; A59410; A59410.
PIR; A59411; A59411.
SMR; Q698K8; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
CDD; cd04269; ZnMc_adamalysin_II_like; 1.
Gene3D; 3.40.390.10; -; 1.
Gene3D; 4.10.70.10; -; 1.
InterPro; IPR018358; Disintegrin_CS.
InterPro; IPR001762; Disintegrin_dom.
InterPro; IPR036436; Disintegrin_dom_sf.
InterPro; IPR024079; MetalloPept_cat_dom_sf.
InterPro; IPR001590; Peptidase_M12B.
InterPro; IPR034027; Reprolysin_adamalysin.
Pfam; PF00200; Disintegrin; 1.
Pfam; PF01421; Reprolysin; 1.
PRINTS; PR00289; DISINTEGRIN.
SMART; SM00050; DISIN; 1.
SUPFAM; SSF57552; SSF57552; 1.
PROSITE; PS50215; ADAM_MEPRO; 1.
PROSITE; PS00427; DISINTEGRIN_1; 1.
PROSITE; PS50214; DISINTEGRIN_2; 1.
PROSITE; PS00142; ZINC_PROTEASE; 1.
1: Evidence at protein level;
Calcium; Cell adhesion impairing toxin; Direct protein sequencing;
Disulfide bond; Hemostasis impairing toxin; Hydrolase; Metal-binding;
Metalloprotease; Platelet aggregation inhibiting toxin; Protease;
Secreted; Toxin; Zinc; Zymogen.
PROPEP <1 28 {ECO:0000250}.
/FTId=PRO_0000424444.
CHAIN 29 230 Snake venom metalloproteinase brevilysin
L4.
/FTId=PRO_0000424445.
PROPEP 231 246 {ECO:0000250}.
/FTId=PRO_0000424446.
CHAIN 247 319 Disintegrin brevicaudin-1b.
/FTId=PRO_0000318180.
CHAIN 249 319 Disintegrin brevicaudin-1a.
/FTId=PRO_0000424447.
DOMAIN 34 230 Peptidase M12B. {ECO:0000255|PROSITE-
ProRule:PRU00276}.
DOMAIN 238 319 Disintegrin. {ECO:0000255|PROSITE-
ProRule:PRU00068}.
MOTIF 297 299 Cell attachment site.
ACT_SITE 171 171 {ECO:0000255|PROSITE-ProRule:PRU00276,
ECO:0000255|PROSITE-ProRule:PRU10095}.
METAL 37 37 Calcium. {ECO:0000250}.
METAL 121 121 Calcium. {ECO:0000250}.
METAL 170 170 Zinc; catalytic. {ECO:0000250}.
METAL 174 174 Zinc; catalytic. {ECO:0000250}.
METAL 180 180 Zinc; catalytic. {ECO:0000250}.
METAL 225 225 Calcium; via carbonyl oxygen.
{ECO:0000250}.
METAL 228 228 Calcium. {ECO:0000250}.
DISULFID 145 225 {ECO:0000250}.
DISULFID 185 209 {ECO:0000250}.
DISULFID 187 192 {ECO:0000250}.
DISULFID 252 261 {ECO:0000250}.
DISULFID 254 262 {ECO:0000250}.
DISULFID 267 281 {ECO:0000250}.
DISULFID 275 305 {ECO:0000250}.
DISULFID 280 284 {ECO:0000250}.
DISULFID 293 312 {ECO:0000250}.
CONFLICT 244 246 ELL -> MHM (in Ref. 2; AAT76292).
{ECO:0000305}.
NON_TER 1 1
SEQUENCE 319 AA; 35314 MW; 093F991FA589B1FA CRC64;
EDEAPKMCGV TQNWESYEPI KKASQSNLTP AHQRYIELVI VADHGMFTKY NGDSDKIREW
VRQMVNTVDE IYSYMYIDVA LAGLEIWSNE DLINVQPAAP HTLDSFGKWR ERDLLHRIHH
DNAMLLTAID FDGPTIGLAY VGTMCKPKGS TGVVQDHSTI NLRVAVTMAH EIGHNLGIHH
DTGSCSCGGY SCIMSPVISH EPSKYFSDCS YTQCWDFIMN QKPQCILNKP LRTDTVSTPV
SGNELLEAGE ECDCGSPGNP CCDAATCKLR QGAQCAEGLC CDQCRFMKKG TVCRIARGDD
MDDYCNGISA GCPRNPFHA


Related products :

Catalog number Product name Quantity
15-288-21429 ADAM 23 - A disintegrin and metalloproteinase domain 23; Metalloproteinase-like. disintegrin-like. and cysteine-rich protein 3; MDC-3 Polyclonal 0.05 mg
15-288-21429 ADAM 23 - A disintegrin and metalloproteinase domain 23; Metalloproteinase-like. disintegrin-like. and cysteine-rich protein 3; MDC-3 Polyclonal 0.1 mg
18-661-15015 ADAM 17 - EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.1 mg
E1319h ELISA ADAM 17,ADAM17,CSVP,Disintegrin and metalloproteinase domain-containing protein 17,Homo sapiens,Human,Snake venom-like protease,TACE,TNF-alpha convertase,TNF-alpha-converting enzyme 96T
E1319h ELISA kit ADAM 17,ADAM17,CSVP,Disintegrin and metalloproteinase domain-containing protein 17,Homo sapiens,Human,Snake venom-like protease,TACE,TNF-alpha convertase,TNF-alpha-converting enzyme 96T
U1319h CLIA ADAM 17,ADAM17,CSVP,Disintegrin and metalloproteinase domain-containing protein 17,Homo sapiens,Human,Snake venom-like protease,TACE,TNF-alpha convertase,TNF-alpha-converting enzyme 96T
18-272-195434 ADAM15 - Rabbit polyclonal to ADAM15; EC 3.4.24.-; A disintegrin and metalloproteinase domain 15; Metalloproteinase-like. disintegrin-like. and cysteine-rich protein 15; MDC-15; Metalloprotease RGD di 0.025 mg
18-272-197022 TACE - Rabbit polyclonal to TACE; EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.1 mg
18-272-195436 TACE - Rabbit polyclonal to TACE; EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.05 mg
18-272-195437 TACE - Rabbit polyclonal to TACE; EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.05 mg
18-272-195435 TACE - Rabbit polyclonal to TACE; EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.05 mg
18-661-15039 ADAM 10 - EC 3.4.24.81; A disintegrin and metalloproteinase domain 10; Mammalian disintegrin-metalloprotease; Kuzbanian protein homolog; CDw156c antigen Polyclonal 0.1 mg
E0766p ELISA kit ADAM 10,ADAM10,Disintegrin and metalloproteinase domain-containing protein 10,Kuzbanian protein homolog,Mammalian disintegrin-metalloprotease,Pig,Sus scrofa 96T
U0766p CLIA ADAM 10,ADAM10,Disintegrin and metalloproteinase domain-containing protein 10,Kuzbanian protein homolog,Mammalian disintegrin-metalloprotease,Pig,Sus scrofa 96T
E0766p ELISA ADAM 10,ADAM10,Disintegrin and metalloproteinase domain-containing protein 10,Kuzbanian protein homolog,Mammalian disintegrin-metalloprotease,Pig,Sus scrofa 96T
E0766m ELISA kit ADAM 10,Adam10,Disintegrin and metalloproteinase domain-containing protein 10,Kuz,Kuzbanian protein homolog,Madm,Mammalian disintegrin-metalloprotease,Mouse,Mus musculus 96T
E0766r ELISA ADAM 10,Adam10,Disintegrin and metalloproteinase domain-containing protein 10,Kuzbanian protein homolog,Madm,Mammalian disintegrin-metalloprotease,Rat,Rattus norvegicus 96T
E0766m ELISA ADAM 10,Adam10,Disintegrin and metalloproteinase domain-containing protein 10,Kuz,Kuzbanian protein homolog,Madm,Mammalian disintegrin-metalloprotease,Mouse,Mus musculus 96T
U0766m CLIA ADAM 10,Adam10,Disintegrin and metalloproteinase domain-containing protein 10,Kuz,Kuzbanian protein homolog,Madm,Mammalian disintegrin-metalloprotease,Mouse,Mus musculus 96T
E0766r ELISA kit ADAM 10,Adam10,Disintegrin and metalloproteinase domain-containing protein 10,Kuzbanian protein homolog,Madm,Mammalian disintegrin-metalloprotease,Rat,Rattus norvegicus 96T
U0766r CLIA ADAM 10,Adam10,Disintegrin and metalloproteinase domain-containing protein 10,Kuzbanian protein homolog,Madm,Mammalian disintegrin-metalloprotease,Rat,Rattus norvegicus 96T
E0766h ELISA ADAM 10,ADAM10,CDw156,Disintegrin and metalloproteinase domain-containing protein 10,Homo sapiens,Human,KUZ,Kuzbanian protein homolog,MADM,Mammalian disintegrin-metalloprotease 96T
U0766h CLIA ADAM 10,ADAM10,CDw156,Disintegrin and metalloproteinase domain-containing protein 10,Homo sapiens,Human,KUZ,Kuzbanian protein homolog,MADM,Mammalian disintegrin-metalloprotease 96T
E0766b ELISA ADAM 10,ADAM10,Bos taurus,Bovine,Disintegrin and metalloproteinase domain-containing protein 10,Kuzbanian protein homolog,MADM,Mammalian disintegrin-metalloprotease,Myelin-associated metalloprot 96T
E0766h ELISA kit ADAM 10,ADAM10,CDw156,Disintegrin and metalloproteinase domain-containing protein 10,Homo sapiens,Human,KUZ,Kuzbanian protein homolog,MADM,Mammalian disintegrin-metalloprotease 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur