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Zinc transporter 10 (ZnT-10) (Manganese transporter SLC30A10) (Solute carrier family 30 member 10)

 ZNT10_HUMAN             Reviewed;         485 AA.
Q6XR72; Q49AL9; Q9NPW0;
04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
02-NOV-2010, sequence version 2.
20-JUN-2018, entry version 118.
RecName: Full=Zinc transporter 10;
Short=ZnT-10;
AltName: Full=Manganese transporter SLC30A10;
AltName: Full=Solute carrier family 30 member 10;
Name=SLC30A10; Synonyms=ZNT10, ZNT8;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Huang L., Zhou B., Gitschier J.;
"Characterization of a novel mammalian zinc transporter, ZNT8.";
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-485 (ISOFORM 3).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
TISSUE SPECIFICITY.
PubMed=15154973; DOI=10.1186/1471-2164-5-32;
Seve M., Chimienti F., Devergnas S., Favier A.;
"In silico identification and expression of SLC30 family genes: an
expressed sequence tag data mining strategy for the characterization
of zinc transporters' tissue expression.";
BMC Genomics 5:32-32(2004).
[6]
FUNCTION, INVOLVEMENT IN HMNDYT1, AND VARIANTS HMNDYT1 PRO-89;
105-ALA--PRO-107 DEL; VAL-256 DEL AND PRO-349.
PubMed=22341972; DOI=10.1016/j.ajhg.2012.01.018;
Tuschl K., Clayton P.T., Gospe S.M. Jr., Gulab S., Ibrahim S.,
Singhi P., Aulakh R., Ribeiro R.T., Barsottini O.G., Zaki M.S.,
Del Rosario M.L., Dyack S., Price V., Rideout A., Gordon K.,
Wevers R.A., Chong W.K., Mills P.B.;
"Syndrome of hepatic cirrhosis, dystonia, polycythemia, and
hypermanganesemia caused by mutations in SLC30A10, a manganese
transporter in man.";
Am. J. Hum. Genet. 90:457-466(2012).
[7]
FUNCTION, INVOLVEMENT IN HMNDYT1, AND VARIANT SER-167.
PubMed=22341971; DOI=10.1016/j.ajhg.2012.01.017;
Quadri M., Federico A., Zhao T., Breedveld G.J., Battisti C.,
Delnooz C., Severijnen L.A., Di Toro Mammarella L., Mignarri A.,
Monti L., Sanna A., Lu P., Punzo F., Cossu G., Willemsen R., Rasi F.,
Oostra B.A., van de Warrenburg B.P., Bonifati V.;
"Mutations in SLC30A10 cause parkinsonism and dystonia with
hypermanganesemia, polycythemia, and chronic liver disease.";
Am. J. Hum. Genet. 90:467-477(2012).
[8]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
PubMed=22706290; DOI=10.1039/c2mt20088k;
Bosomworth H.J., Thornton J.K., Coneyworth L.J., Ford D.,
Valentine R.A.;
"Efflux function, tissue-specific expression and intracellular
trafficking of the Zn transporter ZnT10 indicate roles in adult Zn
homeostasis.";
Metallomics 4:771-779(2012).
[9]
FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SLC30A3, AND
INDUCTION.
PubMed=22427991; DOI=10.1371/journal.pone.0033211;
Patrushev N., Seidel-Rogol B., Salazar G.;
"Angiotensin II requires zinc and downregulation of the zinc
transporters ZnT3 and ZnT10 to induce senescence of vascular smooth
muscle cells.";
PLoS ONE 7:E33211-E33211(2012).
[10]
FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-196, AND
CHARACTERIZATION OF VARIANTS HMNDYT1 PRO-89 AND 105-ALA--PRO-107 DEL.
PubMed=25319704; DOI=10.1523/JNEUROSCI.2329-14.2014;
Leyva-Illades D., Chen P., Zogzas C.E., Hutchens S., Mercado J.M.,
Swaim C.D., Morrisett R.A., Bowman A.B., Aschner M., Mukhopadhyay S.;
"SLC30A10 is a cell surface-localized manganese efflux transporter,
and parkinsonism-causing mutations block its intracellular trafficking
and efflux activity.";
J. Neurosci. 34:14079-14095(2014).
[11]
INDUCTION.
PubMed=25582195; DOI=10.1128/MCB.01298-14;
Ogo O.A., Tyson J., Cockell S.J., Howard A., Valentine R.A., Ford D.;
"The zinc finger protein ZNF658 regulates the transcription of genes
involved in zinc homeostasis and affects ribosome biogenesis through
the zinc transcriptional regulatory element.";
Mol. Cell. Biol. 35:977-987(2015).
[12]
FUNCTION.
PubMed=27226609; DOI=10.1074/jbc.M116.728014;
Nishito Y., Tsuji N., Fujishiro H., Takeda T.A., Yamazaki T.,
Teranishi F., Okazaki F., Matsunaga A., Tuschl K., Rao R., Kono S.,
Miyajima H., Narita H., Himeno S., Kambe T.;
"Direct comparison of manganese detoxification/efflux proteins and
molecular characterization of ZnT10 protein as a manganese
transporter.";
J. Biol. Chem. 291:14773-14787(2016).
[13]
FUNCTION, AND MUTAGENESIS OF GLU-25; ASP-40; ASN-127; HIS-244;
ASP-248; HIS-333 AND HIS-350.
PubMed=27307044; DOI=10.1074/jbc.M116.726935;
Zogzas C.E., Aschner M., Mukhopadhyay S.;
"Structural elements in the transmembrane and cytoplasmic domains of
the metal transporter SLC30A10 are required for its manganese efflux
activity.";
J. Biol. Chem. 291:15940-15957(2016).
[14]
SELF-ASSOCIATION, INTERACTION WITH SLC30A2; SLC30A3 AND SLC30A4,
SUBCELLULAR LOCATION, FUNCTION, AND MUTAGENESIS OF TYR-4.
PubMed=26728129; DOI=10.1111/tra.12371;
Zhao Y., Feresin R.G., Falcon-Perez J.M., Salazar G.;
"Differential targeting of SLC30A10/ZnT10 heterodimers to
endolysosomal compartments modulates EGF-induced MEK/ERK1/2
activity.";
Traffic 17:267-288(2016).
-!- FUNCTION: Plays a pivotal role in manganese transport. Manganese
is an essential cation for the function of several enzymes,
including some crucially important for the metabolism of
neurotransmitters and other neuronal metabolic pathways. However,
elevated levels of manganese are cytotoxic and induce oxidative
stress, mitochondrial dysfunction and apoptosis. Acts as manganese
efflux transporter and confers protection against manganese-
induced cell death (PubMed:22341972, PubMed:22341971,
PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts as
zinc transporter involved in zinc homeostasis. Seems to mediate
zinc transport into early endosomes and recycling endosomes to
prevent zinc toxicity; the function may be regulated by
heterodimerization with other zinc transporters of the SLC30A
subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc
transport-dependent regulation of the EGFR/ERK transduction
pathway in endosomes. May be involved in regulation of zinc-
dependent senescence of vascular smooth muscle cells
(PubMed:22706290, PubMed:22427991, PubMed:26728129).
{ECO:0000269|PubMed:22341971, ECO:0000269|PubMed:22341972,
ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:25319704,
ECO:0000269|PubMed:27226609, ECO:0000305|PubMed:22706290}.
-!- SUBUNIT: Forms homodimers. Forms heterodimers and high-molecular
weight oligomers with SLC30A3, SLC30A2 and SLC30A4;
heterodimerization is mediated by covalent-bound tyrosine residues
and occurs probably in a tissue-specific manner.
{ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:26728129}.
-!- INTERACTION:
Q9BRI3:SLC30A2; NbExp=3; IntAct=EBI-13917996, EBI-8644112;
Q99726:SLC30A3; NbExp=3; IntAct=EBI-13917996, EBI-10294651;
O14863:SLC30A4; NbExp=2; IntAct=EBI-13917996, EBI-13918058;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22706290,
ECO:0000269|PubMed:25319704, ECO:0000269|PubMed:26728129}; Multi-
pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi
network {ECO:0000269|PubMed:22706290}. Recycling endosome
{ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:26728129}. Early
endosome {ECO:0000269|PubMed:22427991}. Note=Relocalized from the
trans-Golgi network to the plasma membrane upon elevated
extracellular Zn concentrations (PubMed:22706290).
{ECO:0000269|PubMed:22706290}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q6XR72-4; Sequence=Displayed;
Name=2;
IsoId=Q6XR72-2; Sequence=VSP_029863;
Note=May be produced at very low levels due to a premature stop
codon in the mRNA, leading to nonsense-mediated mRNA decay.;
Name=3;
IsoId=Q6XR72-3; Sequence=VSP_029864, VSP_029865;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Specifically expressed in fetal liver and
fetal brain (PubMed:15154973). Expressed in adult tissues with
relative levels small intestine > liver > testes > brain > ovary >
colon > cervix > prostate > placenta (PubMed:22706290).
{ECO:0000269|PubMed:15154973, ECO:0000269|PubMed:22706290}.
-!- INDUCTION: Down-regulated by ZNF658 in response to zinc. Down-
regulated by angiotensin-2. {ECO:0000269|PubMed:22427991,
ECO:0000269|PubMed:22706290, ECO:0000269|PubMed:25582195}.
-!- DISEASE: Hypermanganesemia with dystonia 1 (HMNDYT1) [MIM:613280]:
A metabolic autosomal recessive disorder characterized by
dystonia, parkinsonism, extrapyramidal signs, severe
hypermanganesemia, polycythemia, and chronic hepatic disease,
including steatosis and cirrhosis. {ECO:0000269|PubMed:22341971,
ECO:0000269|PubMed:22341972, ECO:0000269|PubMed:25319704}.
Note=The disease is caused by mutations affecting the gene
represented in this entry.
-!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAP44332.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in position 427.; Evidence={ECO:0000305};
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EMBL; AY212919; AAP44332.1; ALT_SEQ; mRNA.
EMBL; AL359609; CAB94880.1; -; mRNA.
EMBL; AC093562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC036078; AAH36078.1; -; mRNA.
CCDS; CCDS31026.1; -. [Q6XR72-4]
PIR; T50628; T50628.
RefSeq; NP_061183.2; NM_018713.2. [Q6XR72-4]
UniGene; Hs.284450; -.
ProteinModelPortal; Q6XR72; -.
IntAct; Q6XR72; 4.
STRING; 9606.ENSP00000355893; -.
TCDB; 2.A.4.2.5; the cation diffusion facilitator (cdf) family.
iPTMnet; Q6XR72; -.
PhosphoSitePlus; Q6XR72; -.
BioMuta; SLC30A10; -.
DMDM; 311033506; -.
PaxDb; Q6XR72; -.
PeptideAtlas; Q6XR72; -.
PRIDE; Q6XR72; -.
ProteomicsDB; 67813; -.
ProteomicsDB; 67814; -. [Q6XR72-2]
ProteomicsDB; 67815; -. [Q6XR72-3]
DNASU; 55532; -.
Ensembl; ENST00000356609; ENSP00000349018; ENSG00000196660. [Q6XR72-3]
Ensembl; ENST00000366926; ENSP00000355893; ENSG00000196660. [Q6XR72-4]
GeneID; 55532; -.
KEGG; hsa:55532; -.
UCSC; uc001hlw.4; human. [Q6XR72-4]
CTD; 55532; -.
DisGeNET; 55532; -.
EuPathDB; HostDB:ENSG00000196660.10; -.
GeneCards; SLC30A10; -.
GeneReviews; SLC30A10; -.
H-InvDB; HIX0001600; -.
HGNC; HGNC:25355; SLC30A10.
HPA; HPA064547; -.
MalaCards; SLC30A10; -.
MIM; 611146; gene.
MIM; 613280; phenotype.
neXtProt; NX_Q6XR72; -.
OpenTargets; ENSG00000196660; -.
Orphanet; 309854; Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome.
PharmGKB; PA142670903; -.
eggNOG; KOG1483; Eukaryota.
eggNOG; COG1230; LUCA.
GeneTree; ENSGT00550000074381; -.
HOGENOM; HOG000166089; -.
HOVERGEN; HBG000588; -.
InParanoid; Q6XR72; -.
KO; K14697; -.
OMA; IFQDCAA; -.
OrthoDB; EOG091G04DT; -.
PhylomeDB; Q6XR72; -.
TreeFam; TF313924; -.
Reactome; R-HSA-425410; Metal ion SLC transporters.
ChiTaRS; SLC30A10; human.
GenomeRNAi; 55532; -.
PRO; PR:Q6XR72; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000196660; -.
CleanEx; HS_SLC30A10; -.
Genevisible; Q6XR72; HS.
GO; GO:0005769; C:early endosome; IDA:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0055037; C:recycling endosome; IDA:UniProtKB.
GO; GO:0005384; F:manganese ion transmembrane transporter activity; TAS:Reactome.
GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
GO; GO:1904385; P:cellular response to angiotensin; IDA:UniProtKB.
GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IDA:UniProtKB.
GO; GO:0071421; P:manganese ion transmembrane transport; IDA:UniProtKB.
GO; GO:0006828; P:manganese ion transport; IMP:UniProtKB.
GO; GO:2000773; P:negative regulation of cellular senescence; IDA:UniProtKB.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:UniProtKB.
GO; GO:1903427; P:negative regulation of reactive oxygen species biosynthetic process; IDA:UniProtKB.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO; GO:1905802; P:regulation of cellular response to manganese ion; IDA:UniProtKB.
GO; GO:0061088; P:regulation of sequestering of zinc ion; IBA:GO_Central.
GO; GO:0071579; P:regulation of zinc ion transport; IDA:UniProtKB.
GO; GO:0010043; P:response to zinc ion; IBA:GO_Central.
Gene3D; 1.20.1510.10; -; 1.
InterPro; IPR002524; Cation_efflux.
InterPro; IPR027469; Cation_efflux_TMD_sf.
Pfam; PF01545; Cation_efflux; 1.
SUPFAM; SSF161111; SSF161111; 2.
TIGRFAMs; TIGR01297; CDF; 1.
1: Evidence at protein level;
Alternative splicing; Cell membrane; Complete proteome;
Disease mutation; Dystonia; Endosome; Golgi apparatus; Ion transport;
Manganese; Membrane; Neurodegeneration; Parkinsonism; Polymorphism;
Reference proteome; Transmembrane; Transmembrane helix; Transport;
Zinc; Zinc transport.
CHAIN 1 485 Zinc transporter 10.
/FTId=PRO_0000312580.
TOPO_DOM 1 10 Cytoplasmic. {ECO:0000255}.
TRANSMEM 11 31 Helical. {ECO:0000255}.
TOPO_DOM 32 40 Extracellular. {ECO:0000255}.
TRANSMEM 41 61 Helical. {ECO:0000255}.
TOPO_DOM 62 81 Cytoplasmic. {ECO:0000255}.
TRANSMEM 82 102 Helical. {ECO:0000255}.
TOPO_DOM 103 113 Extracellular. {ECO:0000255}.
TRANSMEM 114 134 Helical. {ECO:0000255}.
TOPO_DOM 135 244 Cytoplasmic. {ECO:0000255}.
TRANSMEM 245 265 Helical. {ECO:0000255}.
TOPO_DOM 266 278 Extracellular. {ECO:0000255}.
TRANSMEM 279 299 Helical. {ECO:0000255}.
TOPO_DOM 300 485 Cytoplasmic. {ECO:0000255}.
REGION 308 485 Required for plasma membrane
localization.
{ECO:0000269|PubMed:25319704}.
COMPBIAS 253 256 Poly-Val.
COMPBIAS 396 399 Poly-Leu.
VAR_SEQ 1 245 Missing (in isoform 2).
{ECO:0000303|PubMed:17974005}.
/FTId=VSP_029863.
VAR_SEQ 214 223 GDSFNTQNEP -> ELIHNTRFLL (in isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_029864.
VAR_SEQ 224 485 Missing (in isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_029865.
VARIANT 89 89 L -> P (in HMNDYT1; abolishes cell
surface localization; dbSNP:rs281860284).
{ECO:0000269|PubMed:22341972,
ECO:0000269|PubMed:25319704}.
/FTId=VAR_072573.
VARIANT 105 107 Missing (in HMNDYT1; abolishes cell
surface localization; decreases manganese
efflux; decreases protection against
manganese-induced neurotoxity).
{ECO:0000269|PubMed:22341972,
ECO:0000269|PubMed:25319704}.
/FTId=VAR_072574.
VARIANT 167 167 F -> S (in dbSNP:rs281860286).
{ECO:0000269|PubMed:22341971}.
/FTId=VAR_072575.
VARIANT 256 256 Missing (in HMNDYT1).
{ECO:0000269|PubMed:22341972}.
/FTId=VAR_072576.
VARIANT 349 349 L -> P (in HMNDYT1; dbSNP:rs281860291).
{ECO:0000269|PubMed:22341972}.
/FTId=VAR_072577.
MUTAGEN 4 4 Y->F: Decreases interaction with SLC30A3;
no effect on self-association; decreases
zinc transport; decreases EGF-induced
ERK1/2 phosphorylation.
{ECO:0000269|PubMed:26728129}.
MUTAGEN 25 25 E->A: Abolishes manganese efflux
activity. {ECO:0000269|PubMed:27307044}.
MUTAGEN 40 40 D->A: Abolishes manganese efflux
activity. {ECO:0000269|PubMed:27307044}.
MUTAGEN 127 127 N->A: Abolishes manganese efflux
activity; when associated with A-244.
{ECO:0000269|PubMed:27307044}.
MUTAGEN 196 196 T->P: Abolishes cell surface
localization.
{ECO:0000269|PubMed:25319704}.
MUTAGEN 244 244 H->A: Abolishes manganese efflux
activity; when associated with A-127.
{ECO:0000269|PubMed:27307044}.
MUTAGEN 248 248 D->A: Abolishes manganese efflux
activity. {ECO:0000269|PubMed:27307044}.
MUTAGEN 333 333 H->A: Decreases manganese efflux
activity. {ECO:0000269|PubMed:27307044}.
MUTAGEN 350 350 H->A: Decreases manganese efflux
activity. {ECO:0000269|PubMed:27307044}.
SEQUENCE 485 AA; 52684 MW; 96A3495EF026DE94 CRC64;
MGRYSGKTCR LLFMLVLTVA FFVAELVSGY LGNSIALLSD SFNMLSDLIS LCVGLSAGYI
ARRPTRGFSA TYGYARAEVV GALSNAVFLT ALCFTIFVEA VLRLARPERI DDPELVLIVG
VLGLLVNVVG LLIFQDCAAW FACCLRGRSR RLQQRQQLAE GCVPGAFGGP QGAEDPRRAA
DPTAPGSDSA VTLRGTSVER KREKGATVFA NVAGDSFNTQ NEPEDMMKKE KKSEALNIRG
VLLHVMGDAL GSVVVVITAI IFYVLPLKSE DPCNWQCYID PSLTVLMVII ILSSAFPLIK
ETAAILLQMV PKGVNMEELM SKLSAVPGIS SVHEVHIWEL VSGKIIATLH IKYPKDRGYQ
DASTKIREIF HHAGIHNVTI QFENVDLKEP LEQKDLLLLC NSPCISKGCA KQLCCPPGAL
PLAHVNGCAE HNGGPSLDTY GSDGLSRRDA REVAIEVSLD SCLSDHGQSL NKTQEDQCYV
NRTHF


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EIAAB39155 Mouse,Mus musculus,Oatp2a1,PGT,Prostaglandin transporter,Slc21a2,Slco2a1,Solute carrier family 21 member 2,Solute carrier organic anion transporter family member 2A1
EIAAB47983 Mouse,Mus musculus,Slc30a7,Solute carrier family 30 member 7,Zinc transporter 7,Znt7,ZnT-7,Zntl2,Znt-like transporter 2
EIAAB47980 Homo sapiens,Human,SLC30A7,Solute carrier family 30 member 7,Zinc transporter 7,ZNT7,ZnT-7,ZNTL2,Znt-like transporter 2
EIAAB47973 Homo sapiens,Human,hZTL1,SLC30A5,Solute carrier family 30 member 5,UNQ863_PRO1879,Zinc transporter 5,ZNT5,ZnT-5,ZNTL1,ZnT-like transporter 1,ZTL1
EIAAB37037 Homo sapiens,Human,LIV-1 subfamily of ZIP zinc transporter 8,LZT-Hs8,SLC39A12,Solute carrier family 39 member 12,Zinc transporter ZIP12,ZIP12,ZIP-12,Zrt- and Irt-like protein 12
EIAAB37039 Homo sapiens,Human,LIV-1 subfamily of ZIP zinc transporter 9,LZT-Hs9,SLC39A13,Solute carrier family 39 member 13,Zinc transporter ZIP13,ZIP13,ZIP-13,Zrt- and Irt-like protein 13
EIAAB37045 Homo sapiens,Human,KIAA0062,LIV-1 subfamily of ZIP zinc transporter 4,LZT-Hs4,SLC39A14,Solute carrier family 39 member 14,Zinc transporter ZIP14,ZIP14,ZIP-14,Zrt- and Irt-like protein 14
EIAAB37003 Mouse,Mus musculus,mZIP1,Slc39a1,Solute carrier family 39 member 1,Zinc transporter ZIP1,Zinc-iron-regulated transporter-like,Zip1,ZIP-1,Zirtl,Zrt- and Irt-like protein 1
EIAAB37001 CGI-08,CGI-71,Homo sapiens,Human,hZIP1,IRT1,SLC39A1,Solute carrier family 39 member 1,Zinc transporter ZIP1,Zinc-iron-regulated transporter-like,ZIP1,ZIP-1,ZIRTL,Zrt- and Irt-like protein 1
EIAAB36707 Ergothioneine transporter,ET transporter,ETT,Homo sapiens,Human,OCTN1,Organic cation_carnitine transporter 1,SLC22A4,Solute carrier family 22 member 4,UT2H
EIAAB39150 Liver-specific organic anion transporter 1,LST-1,Mouse,Mus musculus,Oatp1b2,Slc21a10,SLC21A6,Slco1b2,Solute carrier family 21 member 10,Solute carrier organic anion transporter family member 1B2
EIAAB36639 Homo sapiens,Human,OCTP,Osteoclast transporter,Peptide transporter 3,Peptide_histidine transporter 2,PHT2,PTR3,SLC15A3,Solute carrier family 15 member 3
EIAAB39158 Oatp2b1,Organic anion transporter moatp1,Rat,Rattus norvegicus,Slc21a9,Slco2b1,Solute carrier family 21 member 9,Solute carrier organic anion transporter family member 2B1
EIAAB39171 Homo sapiens,Human,OATP5A1,OATPRP4,OATP-RP4,Organic anion transporter polypeptide-related protein 4,SLC21A15,SLCO5A1,Solute carrier family 21 member 15,Solute carrier organic anion transporter family
EIAAB12295 Eaat1,Excitatory amino acid transporter 1,GLAST-1,Glial glutamate transporter,Rat,Rattus norvegicus,Slc1a3,Sodium-dependent glutamate_aspartate transporter 1,Solute carrier family 1 member 3
EIAAB39141 OAT-K1,OAT-K2,Oatp1a3,Rat,Rattus norvegicus,rOAT-K,Slc21a4,Slco1a3,Sodium-independent organic anion transporter K1,Solute carrier family 21 member 4,Solute carrier organic anion transporter family mem
EIAAB12308 Eaat4,Excitatory amino acid transporter 4,High-affinity neuronal glutamate transporter,Rat,Rattus norvegicus,Slc1a6,Sodium-dependent glutamate_aspartate transporter,Solute carrier family 1 member 6
EIAAB12307 Eaat4,Excitatory amino acid transporter 4,High-affinity neuronal glutamate transporter,Mouse,Mus musculus,Slc1a6,Sodium-dependent glutamate_aspartate transporter,Solute carrier family 1 member 6
60281 IgG,solute carrier family 30 (zinc transporter), member 9 (SLC30A9) 0.1 mg
EIAAB39168 Homo sapiens,Human,OATP4C1,OATP-H,OATP-M1,OATPX,Organic anion transporter M1,SLC21A20,SLCO4C1,Solute carrier family 21 member 20,Solute carrier organic anion transporter family member 4C1
EIAAB25211 Homo sapiens,Human,MCT 7,MCT 8,MCT8,Monocarboxylate transporter 7,Monocarboxylate transporter 8,SLC16A2,Solute carrier family 16 member 2,X-linked PEST-containing transporter,XPCT


 

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