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Zona pellucida sperm-binding protein 4 (RC55) (Zona pellucida glycoprotein 4) (Zp-4) (Zona pellucida glycoprotein X) (Zp-X) (Zona pellucida protein B) [Cleaved into: Processed zona pellucida sperm-binding protein 4]

 ZP4_RABIT               Reviewed;         540 AA.
Q00193;
01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
01-OCT-1994, sequence version 1.
30-AUG-2017, entry version 109.
RecName: Full=Zona pellucida sperm-binding protein 4;
AltName: Full=RC55;
AltName: Full=Zona pellucida glycoprotein 4;
Short=Zp-4;
AltName: Full=Zona pellucida glycoprotein X;
Short=Zp-X;
AltName: Full=Zona pellucida protein B;
Contains:
RecName: Full=Processed zona pellucida sperm-binding protein 4;
Flags: Precursor;
Name=ZP4; Synonyms=ZPB, ZPX;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 25-49.
TISSUE=Ovary;
PubMed=1707882;
Schwoebel E., Prasad S., Timmons T.M., Cook R., Kimura H., Niu E.-M.,
Cheung P., Skinner S., Avery S.E., Wilkins B., Dunbar B.S.;
"Isolation and characterization of a full-length cDNA encoding the 55-
kDa rabbit zona pellucida protein.";
J. Biol. Chem. 266:7214-7219(1991).
[2]
DOMAINS.
PubMed=8518738; DOI=10.1002/pro.5560020417;
Bork P.;
"A trefoil domain in the major rabbit zona pellucida protein.";
Protein Sci. 2:669-670(1993).
[3]
IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
TISSUE=Ovary;
PubMed=22842159; DOI=10.1016/j.jprot.2012.07.027;
Stetson I., Izquierdo-Rico M.J., Moros C., Chevret P., Lorenzo P.L.,
Ballesta J., Rebollar P.G., Gutierrez-Gallego R., Aviles M.;
"Rabbit zona pellucida composition: a molecular, proteomic and
phylogenetic approach.";
J. Proteomics 75:5920-5935(2012).
-!- FUNCTION: The mammalian zona pellucida, which mediates species-
specific sperm binding, induction of the acrosome reaction and
prevents post-fertilization polyspermy, is composed of three to
four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm
receptor.
-!- SUBCELLULAR LOCATION: Processed zona pellucida sperm-binding
protein 4: Secreted, extracellular space, extracellular matrix
{ECO:0000269|PubMed:22842159}. Note=The glycoproteinaceous
translucent extracellular matrix that surrounds the mammalian
oocyte is called zona pellucida. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22842159};
Single-pass type I membrane protein {ECO:0000255}.
-!- TISSUE SPECIFICITY: Oocytes (at protein level).
{ECO:0000269|PubMed:22842159}.
-!- DOMAIN: The ZP domain is involved in the polymerization of the ZP
proteins to form the zona pellucida. {ECO:0000269|PubMed:8518738}.
-!- PTM: Proteolytically cleaved before the transmembrane segment to
yield the secreted ectodomain incorporated in the zona pellucida.
-!- SIMILARITY: Belongs to the ZP domain family. ZPB subfamily.
{ECO:0000305}.
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EMBL; M58160; AAA31501.1; -; mRNA.
PIR; A39783; A39783.
RefSeq; NP_001075764.1; NM_001082295.2.
UniGene; Ocu.1977; -.
ProteinModelPortal; Q00193; -.
SMR; Q00193; -.
STRING; 9986.ENSOCUP00000022164; -.
Ensembl; ENSOCUT00000032066; ENSOCUP00000022164; ENSOCUG00000002467.
GeneID; 100009131; -.
KEGG; ocu:100009131; -.
CTD; 57829; -.
eggNOG; ENOG410IE4J; Eukaryota.
eggNOG; ENOG4111H75; LUCA.
GeneTree; ENSGT00530000063096; -.
HOGENOM; HOG000059607; -.
HOVERGEN; HBG050410; -.
InParanoid; Q00193; -.
OMA; TRDSIFR; -.
OrthoDB; EOG091G0UNU; -.
TreeFam; TF332794; -.
Proteomes; UP000001811; Chromosome 16.
Bgee; ENSOCUG00000002467; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
GO; GO:0032190; F:acrosin binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0060478; P:acrosomal vesicle exocytosis; IEA:Ensembl.
GO; GO:2000360; P:negative regulation of binding of sperm to zona pellucida; IEA:Ensembl.
GO; GO:2000344; P:positive regulation of acrosome reaction; IEA:Ensembl.
GO; GO:0002922; P:positive regulation of humoral immune response; IEA:Ensembl.
GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
CDD; cd00111; Trefoil; 1.
InterPro; IPR017957; P_trefoil_CS.
InterPro; IPR000519; P_trefoil_dom.
InterPro; IPR001507; ZP_dom.
InterPro; IPR017977; ZP_dom_CS.
Pfam; PF00088; Trefoil; 1.
Pfam; PF00100; Zona_pellucida; 1.
PRINTS; PR00023; ZPELLUCIDA.
SMART; SM00018; PD; 1.
SMART; SM00241; ZP; 1.
PROSITE; PS00025; P_TREFOIL_1; 1.
PROSITE; PS51448; P_TREFOIL_2; 1.
PROSITE; PS00682; ZP_1; 1.
PROSITE; PS51034; ZP_2; 1.
1: Evidence at protein level;
Cell membrane; Cleavage on pair of basic residues; Complete proteome;
Direct protein sequencing; Disulfide bond; Extracellular matrix;
Fertilization; Glycoprotein; Membrane; Receptor; Reference proteome;
Secreted; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 24 {ECO:0000269|PubMed:1707882}.
CHAIN 25 466 Zona pellucida sperm-binding protein 4.
/FTId=PRO_0000041731.
CHAIN 25 ? Processed zona pellucida sperm-binding
protein 4.
/FTId=PRO_0000304580.
PROPEP 467 540 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000041732.
TOPO_DOM 25 515 Extracellular. {ECO:0000255}.
TRANSMEM 516 536 Helical. {ECO:0000255}.
TOPO_DOM 537 540 Cytoplasmic. {ECO:0000255}.
DOMAIN 145 187 P-type. {ECO:0000255|PROSITE-
ProRule:PRU00779}.
DOMAIN 192 470 ZP. {ECO:0000255|PROSITE-
ProRule:PRU00375}.
COMPBIAS 299 318 Pro-rich.
CARBOHYD 76 76 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 97 97 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 206 206 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
CARBOHYD 223 223 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
CARBOHYD 296 296 O-linked (GalNAc...) serine.
{ECO:0000250}.
CARBOHYD 306 306 O-linked (GalNAc...) threonine.
{ECO:0000250}.
CARBOHYD 478 478 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 482 482 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 371 446 {ECO:0000255|PROSITE-ProRule:PRU00779}.
SEQUENCE 540 AA; 59835 MW; 030EE13D057F6D6F CRC64;
MAPGSTMWLL GYIFLCFPVS FALIKQPKPE TPTDPGVLHC RPWNFKFTIN FQNQETGSSP
VLVTWDNQGR LHRLQNDTDC GTRVGEGPGP SVVLEANYSS CYVTESEPYY VMLVGVEEVD
AAGQNLVTKQ QLLKCPMHLP APDAGLCDSV PVQDRLPCAT APISQEDCEE LGCCHSSEEV
NACYYGNTVT SHCTQEGHFS IAVSRNVSSP PLHLDSVHLV FGNDSECQPV VATRAFVLFL
FPFTACGTTR QITGDRAIYE NELLATREVR TWSRGSITRD SIFRLRVSCS YSISSSALPV
DMHVLTLPPP LPETQPGPLT VVLQIAKDKD YHSYYTMDDY PVVKLLRDPI YVDVSILYRT
DPYLGLRLHQ CWATPRTNPL YQPQWPILVK GCPYTGDNYQ TQLIPVQEAF DLPFPSHHQR
FSISTFSFLD SSVAKEALKG PIYLHCSVSV CQPTGTQSCT VTCPIDSRRR NSDINFQNST
ANISSKGPMI LLQATEDPSE KLHKHSGVPV HPGALWVAGL SGIFIIGALL VSYVAIRTRR


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