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dITP/XTP pyrophosphatase (EC 3.6.1.66) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)

 A0A1Q6A338_9SPHI        Unreviewed;       193 AA.
A0A1Q6A338;
12-APR-2017, integrated into UniProtKB/TrEMBL.
12-APR-2017, sequence version 1.
27-SEP-2017, entry version 4.
RecName: Full=dITP/XTP pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01405};
EC=3.6.1.66 {ECO:0000256|HAMAP-Rule:MF_01405};
AltName: Full=Non-canonical purine NTP pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01405};
AltName: Full=Non-standard purine NTP pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01405};
AltName: Full=Nucleoside-triphosphate diphosphatase {ECO:0000256|HAMAP-Rule:MF_01405};
AltName: Full=Nucleoside-triphosphate pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01405};
Short=NTPase {ECO:0000256|HAMAP-Rule:MF_01405};
ORFNames=RG47T_3897 {ECO:0000313|EMBL:OKS88430.1};
Mucilaginibacter polytrichastri.
Bacteria; Bacteroidetes; Sphingobacteriia; Sphingobacteriales;
Sphingobacteriaceae; Mucilaginibacter.
NCBI_TaxID=1302689 {ECO:0000313|EMBL:OKS88430.1, ECO:0000313|Proteomes:UP000186720};
[1] {ECO:0000313|EMBL:OKS88430.1, ECO:0000313|Proteomes:UP000186720}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=RG4-7 {ECO:0000313|EMBL:OKS88430.1,
ECO:0000313|Proteomes:UP000186720};
Li Y.;
"Whole Genome Sequencing of Mucilaginibacter polytrichastri RG4-7(T)
isolated from the moss sample.";
Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Pyrophosphatase that catalyzes the hydrolysis of
nucleoside triphosphates to their monophosphate derivatives, with
a high preference for the non-canonical purine nucleotides XTP
(xanthosine triphosphate), dITP (deoxyinosine triphosphate) and
ITP. Seems to function as a house-cleaning enzyme that removes
non-canonical purine nucleotides from the nucleotide pool, thus
preventing their incorporation into DNA/RNA and avoiding
chromosomal lesions. {ECO:0000256|HAMAP-Rule:MF_01405,
ECO:0000256|SAAS:SAAS00805977}.
-!- CATALYTIC ACTIVITY: ITP + H(2)O = IMP + diphosphate.
{ECO:0000256|HAMAP-Rule:MF_01405, ECO:0000256|SAAS:SAAS00805978}.
-!- CATALYTIC ACTIVITY: XTP + H(2)O = XMP + diphosphate.
{ECO:0000256|HAMAP-Rule:MF_01405, ECO:0000256|SAAS:SAAS00805983}.
-!- CATALYTIC ACTIVITY: dITP + H(2)O = dIMP + diphosphate.
{ECO:0000256|HAMAP-Rule:MF_01405, ECO:0000256|SAAS:SAAS00805979}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|HAMAP-Rule:MF_01405};
Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|HAMAP-
Rule:MF_01405};
-!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01405,
ECO:0000256|SAAS:SAAS00730484}.
-!- SIMILARITY: Belongs to the HAM1 NTPase family. {ECO:0000256|HAMAP-
Rule:MF_01405, ECO:0000256|RuleBase:RU003781,
ECO:0000256|SAAS:SAAS00730348}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:OKS88430.1}.
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EMBL; MPPL01000001; OKS88430.1; -; Genomic_DNA.
RefSeq; WP_074491007.1; NZ_MPPL01000001.1.
Proteomes; UP000186720; Unassembled WGS sequence.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
GO; GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IEA:UniProtKB-UniRule.
GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
GO; GO:0009146; P:purine nucleoside triphosphate catabolic process; IEA:UniProtKB-UniRule.
CDD; cd00515; HAM1; 1.
Gene3D; 3.90.950.10; -; 1.
HAMAP; MF_01405; Non_canon_purine_NTPase; 1.
InterPro; IPR020922; dITP/XTP_pyrophosphatase.
InterPro; IPR002637; Ham1p-like.
InterPro; IPR029001; ITPase-like_fam.
PANTHER; PTHR11067; PTHR11067; 1.
Pfam; PF01725; Ham1p_like; 1.
SUPFAM; SSF52972; SSF52972; 1.
TIGRFAMs; TIGR00042; TIGR00042; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000186720};
Hydrolase {ECO:0000256|HAMAP-Rule:MF_01405,
ECO:0000256|RuleBase:RU003781, ECO:0000256|SAAS:SAAS00730407};
Magnesium {ECO:0000256|HAMAP-Rule:MF_01405,
ECO:0000256|SAAS:SAAS00730390};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_01405,
ECO:0000256|SAAS:SAAS00730432};
Nucleotide metabolism {ECO:0000256|HAMAP-Rule:MF_01405,
ECO:0000256|SAAS:SAAS00730340};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01405,
ECO:0000256|SAAS:SAAS00730332};
Reference proteome {ECO:0000313|Proteomes:UP000186720}.
REGION 9 14 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_01405}.
REGION 150 153 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_01405}.
REGION 178 179 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_01405}.
ACT_SITE 70 70 Proton acceptor. {ECO:0000256|HAMAP-
Rule:MF_01405}.
METAL 41 41 Magnesium. {ECO:0000256|HAMAP-
Rule:MF_01405}.
METAL 70 70 Magnesium. {ECO:0000256|HAMAP-
Rule:MF_01405}.
BINDING 71 71 Substrate; via amide nitrogen.
{ECO:0000256|HAMAP-Rule:MF_01405}.
BINDING 173 173 Substrate. {ECO:0000256|HAMAP-
Rule:MF_01405}.
SEQUENCE 193 AA; 21740 MW; C5808D48ED65B83C CRC64;
MPYQLVFATN NRHKLEEVAA KTGDKFSLLT LSDIGCTDEI EENGSTFNEN ASIKSNYVFN
HYQLDCFGDD SGLEIDALNG EPGIYSARYA GTHGDHDANI NKVLDKLKNE TNCKARFRTV
ISLLWKGEEH FFEGTVEGTI RPHRSGAEGF GYDPIFQPDG YDVTFAEMSM EEKNAISHRA
IAMEKLLEFL KER


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