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leucine-rich repeat serine/threonine-protein kinase 2

 A0A1U7U4B5_TARSY        Unreviewed;      2527 AA.
A0A1U7U4B5;
10-MAY-2017, integrated into UniProtKB/TrEMBL.
10-MAY-2017, sequence version 1.
05-DEC-2018, entry version 13.
SubName: Full=leucine-rich repeat serine/threonine-protein kinase 2 {ECO:0000313|RefSeq:XP_008060122.1};
Name=LRRK2 {ECO:0000313|RefSeq:XP_008060122.1};
Tarsius syrichta (Philippine tarsier).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Tarsiiformes; Tarsiidae; Carlito.
NCBI_TaxID=1868482 {ECO:0000313|Proteomes:UP000189704, ECO:0000313|RefSeq:XP_008060122.1};
[1] {ECO:0000313|RefSeq:XP_008060122.1}
IDENTIFICATION.
RefSeq;
Submitted (APR-2017) to UniProtKB.
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RefSeq; XP_008060122.1; XM_008061931.1.
GeneID; 103264290; -.
CTD; 120892; -.
Proteomes; UP000189704; Genome assembly.
GO; GO:0044753; C:amphisome; IEA:Ensembl.
GO; GO:0044754; C:autolysosome; IEA:Ensembl.
GO; GO:0099400; C:caveola neck; IEA:Ensembl.
GO; GO:0032473; C:cytoplasmic side of mitochondrial outer membrane; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0032839; C:dendrite cytoplasm; IEA:Ensembl.
GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0005798; C:Golgi-associated vesicle; IEA:Ensembl.
GO; GO:0030426; C:growth cone; IEA:Ensembl.
GO; GO:0016234; C:inclusion body; IEA:Ensembl.
GO; GO:0005902; C:microvillus; IEA:Ensembl.
GO; GO:0097487; C:multivesicular body, internal vesicle; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0043204; C:perikaryon; IEA:Ensembl.
GO; GO:1990909; C:Wnt signalosome; IEA:Ensembl.
GO; GO:0003779; F:actin binding; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:InterPro.
GO; GO:0030276; F:clathrin binding; IEA:Ensembl.
GO; GO:0005525; F:GTP binding; IEA:Ensembl.
GO; GO:0034211; F:GTP-dependent protein kinase activity; IEA:Ensembl.
GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
GO; GO:0004708; F:MAP kinase kinase activity; IEA:Ensembl.
GO; GO:0036479; F:peroxidase inhibitor activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0051018; F:protein kinase A binding; IEA:Ensembl.
GO; GO:0017048; F:Rho GTPase binding; IEA:Ensembl.
GO; GO:0017075; F:syntaxin-1 binding; IEA:Ensembl.
GO; GO:0015631; F:tubulin binding; IEA:Ensembl.
GO; GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
GO; GO:1903351; P:cellular response to dopamine; IEA:Ensembl.
GO; GO:0071287; P:cellular response to manganese ion; IEA:Ensembl.
GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
GO; GO:0008340; P:determination of adult lifespan; IEA:Ensembl.
GO; GO:0006897; P:endocytosis; IEA:Ensembl.
GO; GO:0007029; P:endoplasmic reticulum organization; IEA:Ensembl.
GO; GO:0035640; P:exploration behavior; IEA:Ensembl.
GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
GO; GO:0046039; P:GTP metabolic process; IEA:Ensembl.
GO; GO:0048312; P:intracellular distribution of mitochondria; IEA:Ensembl.
GO; GO:1902902; P:negative regulation of autophagosome assembly; IEA:Ensembl.
GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0034260; P:negative regulation of GTPase activity; IEA:Ensembl.
GO; GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IEA:Ensembl.
GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
GO; GO:0032091; P:negative regulation of protein binding; IEA:Ensembl.
GO; GO:0010955; P:negative regulation of protein processing; IEA:Ensembl.
GO; GO:1903215; P:negative regulation of protein targeting to mitochondrion; IEA:Ensembl.
GO; GO:1903125; P:negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0007528; P:neuromuscular junction development; IEA:Ensembl.
GO; GO:0070997; P:neuron death; IEA:Ensembl.
GO; GO:0048812; P:neuron projection morphogenesis; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0060161; P:positive regulation of dopamine receptor signaling pathway; IEA:Ensembl.
GO; GO:0043068; P:positive regulation of programmed cell death; IEA:Ensembl.
GO; GO:1902499; P:positive regulation of protein autoubiquitination; IEA:Ensembl.
GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0070973; P:protein localization to endoplasmic reticulum exit site; IEA:Ensembl.
GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:2000172; P:regulation of branching morphogenesis of a nerve; IEA:Ensembl.
GO; GO:1905289; P:regulation of CAMKK-AMPK signaling cascade; IEA:Ensembl.
GO; GO:0061001; P:regulation of dendritic spine morphogenesis; IEA:Ensembl.
GO; GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO; GO:0035751; P:regulation of lysosomal lumen pH; IEA:Ensembl.
GO; GO:0051900; P:regulation of mitochondrial depolarization; IEA:Ensembl.
GO; GO:1902692; P:regulation of neuroblast proliferation; IEA:Ensembl.
GO; GO:0014041; P:regulation of neuron maturation; IEA:Ensembl.
GO; GO:1905279; P:regulation of retrograde transport, endosome to Golgi; IEA:Ensembl.
GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IEA:Ensembl.
GO; GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; IEA:Ensembl.
GO; GO:1904887; P:Wnt signalosome assembly; IEA:Ensembl.
Gene3D; 1.25.10.10; -; 2.
Gene3D; 1.25.40.20; -; 1.
Gene3D; 2.130.10.10; -; 1.
Gene3D; 3.80.10.10; -; 2.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR011989; ARM-like.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR032171; COR.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR020859; ROC_dom.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR036322; WD40_repeat_dom_sf.
Pfam; PF16095; COR; 1.
Pfam; PF13855; LRR_8; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00369; LRR_TYP; 7.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF48371; SSF48371; 2.
SUPFAM; SSF50978; SSF50978; 1.
SUPFAM; SSF52540; SSF52540; 1.
SUPFAM; SSF56112; SSF56112; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51450; LRR; 11.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PROSITE; PS51424; ROC; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000189704};
Kinase {ECO:0000313|RefSeq:XP_008060122.1};
Reference proteome {ECO:0000313|Proteomes:UP000189704};
Transferase {ECO:0000313|RefSeq:XP_008060122.1}.
DOMAIN 1328 1511 Roc. {ECO:0000259|PROSITE:PS51424}.
DOMAIN 1879 2146 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
COILED 326 346 {ECO:0000256|SAM:Coils}.
SEQUENCE 2527 AA; 285736 MW; FC85140395071BD9 CRC64;
MASGSRQGCE EDEETLKKLI VRLNNVQEGK QIETLVQILE DLLVFTYAEH AFKLFQGKNV
HVPLLIVLDS YMRVASVQQV GWSLLCKLIE ISPDTMQSLM GPQDIGNDWE VLGVHQLILK
MLTIHNASVN LSTIGLKVLD LLLTSGKITL LILDEESDIF LLIFDAMHTF SANDEVQKLG
CKALHVLFER VSEEQLIEFV ENKDYMILLS ALKHFKDEED IVLHVLHCLH SLAIPCNNVE
VLMSGNVRCY NIVVEAMKAF PVSEKIQEVS CCLLHRLTLG NFFNILVLNE VHEFVVKAVK
QYPENAALQI SALSCLALLT ETIFLNQDLE EKSENQENDD EEEEDKLFWL EACYKALTWH
RKNKHVQEAA CWALNNLLMY QNSLHKKIGD EDDQFPAHRE VMLSMLMHSS SKDVFQSSAN
ALSTLLEQNV NFRKILLSKG IYLNVLELMQ KHIHSPEVAE SGCKMLSHLF EGSNTSLDTV
AAVVPKITAV MKSHETSLSV QLEALRAILH FLVPDFPEES REDTESQRKL NMIKKQCFKN
NIHKLVLAAL NRFIGNPGIQ KCGLKVISSI AHYPDVLEIL SLEGAVDSVL HTLQMYPDDQ
EIQYLGLSLI GCLITKKNLC IGTGHLLAKI LVSSLQRFKD VAEVQTKGFQ TILAILELSV
SFSKLLVNHS FDSVIFYQMS SGILEQKDQQ FLNLCCKCFA KLATDDQLKS VMLERACDQN
NSIMVECLLL LGADTNQAKE STSLICQVCE KESSPKLVEL LLNNGSREQD VRKALTISIR
KGDSQVISLL LQRLALDMAN NSICLGGFCI GKIEPSWLGP LFPDKTSNLR KQANIGSTLA
RMVLRYQMKS SIEEGAAAGS NGNFSEDVLD KFDEWTFIPD SSMDSVFAQS DDLDSEGSEG
SFLVKKKSNS ISVGEFYRDR ALQRCSPNLQ RHSNSLGPIL DHEDLLKRKR KILSSDDSLR
SSKLQSHMRH SDSISSLASE REYITSLDLS ANELRDIDAL SQKCCISGHL EHLEKLELHQ
NVLTSFPQQL CETLKRLTHL DLHSNKFTSF PSYLLKMNCV AYLDVSRNDI GPSVALDPAM
KCPTLKQFNL SYNQLSSVPE NLAEVVEKLE QLILEGNKIS GICSSLSLKE LKILNLSKNH
ISSLSENFLE SCPKVESFSA RMNSLAAMPS LPSSITSLKL SQNKFTCVPE AILNLPHLRS
LDMNSNDIQY LPGPAHWKSL NLRELLFSYN QISILDLSEK AYLWSRVEKL HLSHNKLKEI
PPEIGCLENL TSLDVSYNLE LKSFPNEMGK LSKIWDLPLD ELHLNFDFKH IGCKAKDIIR
FLQQRLKKAV PYNRMKLMIV GNTGSGKTTL LQQLMKTKKS DLGMQNSTVG IDVKDWPIQI
RGKRKKDLIL NVWDFAGREE FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA
RASSSPVILV GTHLDVSDEK QRKACISKIT KELLNKRGFP AIRDYHFVNA TEESDALAKL
RKTIINESLN FKIRDQPVVG QLIPDCYVEL EKIILSERKN VPIEFPVIDR KRLLQLVREN
QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP KWLCKIMAQI LTVKVEGCPK
HPKGIISRRD VEKFLSKKKR FPKNYMLQYF KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI
ELPHCENSEI IIRLYEMPYF PMGFWSRLIS RLLEISPYML SGRERALRPN RMYWRQGIYL
NWSPEAYCLV GSEVLDNHPE SFLKITVPSC RKGCILLGQV VDHIDSLMEE WFPGLLEIDI
CGEGETLLKK WALYSFNDGE EHQKILLDDL MKKAEEGDLL VNPDQPRLTI PISQIAPDLI
LADLPRNIML NHDELEFEQS PEFLLGDGSF GSVYRAAYEG EEVAVKIFNK HTSLRLLRQE
LVVLCHLHHP SLISLLAAGI RPRMLVMELA SKGSLDRLLQ HDKASLTRTL QHRIALHVAD
GLRYLHSAMI IYRDLKPHNV LLFTLYPNAA IIAKIADYGI AQYCCRMGIK TSEGTPGFRA
PEVARGNVIY NQQADVYSFG LLLYDILTTG GRIVEGLKFP NEFDELAIQG KLPDPVKEYG
CAPWPMVEKL IKKCLKENPQ ERPTSAQVFD ILNSAELICL MRHILLPKNV VVECMAATHH
NSKNASIWLG CGHTDKGQLS FLDLNTEEHT SEEVTDSRIL CLTLVHLPVE KESWIVSGMQ
SGTLLVTSTE DGKKRHTLEK MTDSVTCLYC SSFSKQSKQK NFLLVGTADG NLAIFEDKTI
KFKGAAPLKI LNIGNVSTPL MCLSESTNST EKNIMWGGCG TKIFSFSNEF TIQKLIETRT
NQLFSYAAFS DSNIIAVVVD TALYIAKKNS PVVEVWDKKT EKLCELIDCV HFLKEVMVKI
NKESKHKMTY SGRVKTLCLQ KNTALWIGTG GGHVLLLDLS TRRIICIIYN FCDSVRVMMP
AQLGSLKNVM LVLGYNRKST EGTQQHKEIQ SCLTVWDINL PHEVQNLEKH IEVRNELAEK
MRGTSVE


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