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mRNA export factor ICP27 homolog (Immediate-early protein 4) (IE4) (Transcriptional transactivator IE4)

 ICP27_VZVD              Reviewed;         452 AA.
P09269;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
12-APR-2017, entry version 70.
RecName: Full=mRNA export factor ICP27 homolog;
AltName: Full=Immediate-early protein 4;
Short=IE4;
AltName: Full=Transcriptional transactivator IE4;
ORFNames=ORF4;
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Alphaherpesvirinae; Varicellovirus.
NCBI_TaxID=10338;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=3018124;
Davison A.J., Scott J.E.;
"The complete DNA sequence of varicella-zoster virus.";
J. Gen. Virol. 67:1759-1816(1986).
[2]
FUNCTION.
PubMed=9261438;
Defechereux P., Debrus S., Baudoux L., Rentier B., Piette J.;
"Varicella-zoster virus open reading frame 4 encodes an immediate-
early protein with posttranscriptional regulatory properties.";
J. Virol. 71:7073-7079(1997).
[3]
INTERACTION WITH IE62.
PubMed=10873781; DOI=10.1006/viro.2000.0389;
Spengler M.L., Ruyechan W.T., Hay J.;
"Physical interaction between two varicella zoster virus gene
regulatory proteins, IE4 and IE62.";
Virology 272:375-381(2000).
[4]
SUBUNIT.
PubMed=10889190; DOI=10.1074/jbc.M001444200;
Baudoux L., Defechereux P., Rentier B., Piette J.;
"Gene activation by Varicella-zoster virus IE4 protein requires its
dimerization and involves both the arginine-rich sequence, the central
part, and the carboxyl-terminal cysteine-rich region.";
J. Biol. Chem. 275:32822-32831(2000).
[5]
FUNCTION, AND INTERACTION WITH HUMAN SRSF1; SRSF3; SRSF7 AND SRPK1.
STRAIN=NIK;
PubMed=19924249; DOI=10.1371/journal.pone.0007882;
Ote I., Lebrun M., Vandevenne P., Bontems S., Medina-Palazon C.,
Manet E., Piette J., Sadzot-Delvaux C.;
"Varicella-zoster virus IE4 protein interacts with SR proteins and
exports mRNAs through the TAP/NXF1 pathway.";
PLoS ONE 4:E7882-E7882(2009).
-!- FUNCTION: Multifunctional regulator of the expression of viral
genes that mediates nuclear export of viral intronless mRNAs. This
immediate early (EI) protein promotes the nuclear export of viral
intronless mRNAs by interacting with mRNAs and host NXF1/TAP (By
similarity). {ECO:0000250, ECO:0000269|PubMed:19924249,
ECO:0000269|PubMed:9261438}.
-!- SUBUNIT: Homodimer. Homodimerization is required for
transactivation. Associates in a complex with RNA, and host export
factors NXF1/TAP and ALYREF; these interactions allow nuclear
export of viral transcripts. Interacts with three host shuttling
SR proteins SRSF1, SRSF3 and SRSF7. Interacts with host SRPK1.
Interacts with IE62; this interaction enhances IE62
transactivation. {ECO:0000269|PubMed:10873781,
ECO:0000269|PubMed:10889190, ECO:0000269|PubMed:19924249}.
-!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Host nucleus
{ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm
(Probable). IE4 utilizes, at least, XPO1/CRM1 as a cofactor for
nuclear export. {ECO:0000305}.
-!- DOMAIN: Binds viral intronless RNAs and SR proteins through the
Arg-rich region.
-!- PTM: Phosphorylated in vitro by SRPK1.
-!- SIMILARITY: Belongs to the HHV-1 ICP27 protein family.
{ECO:0000305}.
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EMBL; X04370; CAA27887.1; -; Genomic_DNA.
PIR; D27212; WZBE4.
SMR; P09269; -.
PRIDE; P09269; -.
OrthoDB; VOG09000093; -.
Proteomes; UP000002602; Genome.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0016032; P:viral process; IEA:UniProtKB-KW.
InterPro; IPR008648; ICP27-like.
Pfam; PF05459; Herpes_UL69; 1.
1: Evidence at protein level;
Activator; Complete proteome; Early protein; Host cytoplasm;
Host nucleus; Host-virus interaction; Metal-binding;
Reference proteome; RNA-binding; Transcription;
Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 452 mRNA export factor ICP27 homolog.
/FTId=PRO_0000115831.
ZN_FING 335 426 CHC2-type.
{ECO:0000250|UniProtKB:P10238}.
COMPBIAS 71 143 Arg-rich.
COMPBIAS 405 452 Cys-rich.
METAL 335 335 Zinc. {ECO:0000250|UniProtKB:P10238}.
METAL 417 417 Zinc. {ECO:0000250|UniProtKB:P10238}.
METAL 421 421 Zinc. {ECO:0000250|UniProtKB:P10238}.
METAL 426 426 Zinc. {ECO:0000250|UniProtKB:P10238}.
SEQUENCE 452 AA; 51543 MW; 42926E4A71E380B4 CRC64;
MASASIPTDP DVSTICEDFM NLLPDEPSDD FALEVTDWAN DEAIGSTPGE DSTTSRTVYV
ERTADTAYNP RYSKRRHGRR ESYHHNRPKT LVVVLPDSNH HGGRDVETGY ARIERGHRRS
SRSYNTQSSR KHRDRSLSNR RRRPTTPPAM TTGERNDQTH DESYRLRFSK RDARRERIRK
EYDIPVDRIT GRAIEVVSTA GASVTIDSVR HLDETIEKLV VRYATIQEGD SWASGGCFPG
IKQNTSWPEL MLYGHELYRT FESYKMDSRI ARALRERVIR GESLIEALES ADELLTWIKM
LAAKNLPIYT NNPIVATSKS LLENLKLKLG PFVRCLLLNR DNDLGSRTLP ELLRQQRFSD
ITCITTYMFV MIARIANIVV RGSKFVEYDD ISCNVQVLQE YTPGSCLAGV LEALITHQRE
CGRVECTLST WAGHLSDARP YGKYFKCSTF NC


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