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multidrug resistance regulator 2

 MRR2_CANAL              Reviewed;         710 AA.
Q59MJ1; A0A1D8PKW3;
01-APR-2015, integrated into UniProtKB/Swiss-Prot.
26-APR-2005, sequence version 1.
22-NOV-2017, entry version 83.
RecName: Full=multidrug resistance regulator 2 {ECO:0000303|PubMed:23844834};
Name=MRR2 {ECO:0000303|PubMed:23844834};
Synonyms=ZCF34 {ECO:0000303|PubMed:22073120};
OrderedLocusNames=CAALFM_C307860CA; ORFNames=CaO19.6182;
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
Candida/Lodderomyces clade; Candida.
NCBI_TaxID=237561;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=15123810; DOI=10.1073/pnas.0401648101;
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
Davis R.W., Scherer S.;
"The diploid genome sequence of Candida albicans.";
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
[2]
GENOME REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
Chibana H., Nantel A., Magee P.T.;
"Assembly of the Candida albicans genome into sixteen supercontigs
aligned on the eight chromosomes.";
Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
"Assembly of a phased diploid Candida albicans genome facilitates
allele-specific measurements and provides a simple model for repeat
and indel structure.";
Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
[4]
IDENTIFICATION.
PubMed=18629206; DOI=10.1002/cfg.492;
Maicas S., Moreno I., Nieto A., Gomez M., Sentandreu R., Valentin E.;
"In silico analysis for transcription factors with Zn(II)(2)C(6)
binuclear cluster DNA-binding domains in Candida albicans.";
Comp. Funct. Genomics 6:345-356(2005).
[5]
IDENTIFICATION, FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=22073120; DOI=10.1371/journal.pone.0026962;
Vandeputte P., Ischer F., Sanglard D., Coste A.T.;
"In vivo systematic analysis of Candida albicans Zn2-Cys6
transcription factors mutants for mice organ colonization.";
PLoS ONE 6:E26962-E26962(2011).
[6]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=22359502; DOI=10.1371/journal.ppat.1002525;
Finkel J.S., Xu W., Huang D., Hill E.M., Desai J.V., Woolford C.A.,
Nett J.E., Taff H., Norice C.T., Andes D.R., Lanni F., Mitchell A.P.;
"Portrait of Candida albicans adherence regulators.";
PLoS Pathog. 8:E1002525-E1002525(2012).
[7]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=23844834; DOI=10.1111/mmi.12327;
Schillig R., Morschhauser J.;
"Analysis of a fungus-specific transcription factor family, the
Candida albicans zinc cluster proteins, by artificial activation.";
Mol. Microbiol. 89:1003-1017(2013).
-!- FUNCTION: Transcription factor that controls the expression of
CDR1, the major multidrug efflux pump. Required for yeast cell
adherence to silicone substrate and plays a role in virulence.
{ECO:0000269|PubMed:22073120, ECO:0000269|PubMed:22359502,
ECO:0000269|PubMed:23844834}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00227}. Membrane {ECO:0000255}; Multi-pass membrane
protein {ECO:0000255}.
-!- DISRUPTION PHENOTYPE: Leads to increased drug susceptibility.
Displays decreased colonization of mouse kidneys. Shows decreased
yeast cell adherence to silicone substrate.
{ECO:0000269|PubMed:22073120, ECO:0000269|PubMed:22359502,
ECO:0000269|PubMed:23844834}.
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EMBL; CP017625; AOW28784.1; -; Genomic_DNA.
RefSeq; XP_710938.1; XM_705846.1.
ProteinModelPortal; Q59MJ1; -.
SMR; Q59MJ1; -.
PRIDE; Q59MJ1; -.
EnsemblFungi; AOW28784; AOW28784; CAALFM_C307860CA.
GeneID; 3647468; -.
KEGG; cal:CAALFM_C307860CA; -.
CGD; CAL0000180700; MRR2.
EuPathDB; FungiDB:C3_07860C_A; -.
InParanoid; Q59MJ1; -.
OrthoDB; EOG092C15L8; -.
Proteomes; UP000000559; Chromosome 3.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISO:CGD.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0035690; P:cellular response to drug; IMP:CGD.
GO; GO:0044117; P:growth of symbiont in host; IMP:CGD.
GO; GO:1900189; P:positive regulation of cell adhesion involved in single-species biofilm formation; IMP:CGD.
GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IMP:CGD.
GO; GO:2001040; P:positive regulation of cellular response to drug; IMP:CGD.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:CGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:CGD.
GO; GO:0044011; P:single-species biofilm formation on inanimate substrate; IMP:CGD.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00067; GAL4; 1.
Gene3D; 4.10.240.10; -; 1.
InterPro; IPR007219; Transcription_factor_dom_fun.
InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
Pfam; PF04082; Fungal_trans; 1.
Pfam; PF00172; Zn_clus; 1.
SMART; SM00066; GAL4; 1.
SUPFAM; SSF57701; SSF57701; 1.
PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
3: Inferred from homology;
Activator; Complete proteome; DNA-binding; Membrane; Metal-binding;
Nucleus; Reference proteome; Transcription; Transcription regulation;
Transmembrane; Transmembrane helix; Zinc.
CHAIN 1 710 multidrug resistance regulator 2.
/FTId=PRO_0000431800.
TRANSMEM 475 495 Helical; Name=1. {ECO:0000255}.
TRANSMEM 525 545 Helical; Name=2. {ECO:0000255}.
DNA_BIND 11 37 Zn(2)-C6 fungal-type.
{ECO:0000255|PROSITE-ProRule:PRU00227}.
SEQUENCE 710 AA; 82103 MW; E449624B2C350E3A CRC64;
MTKRDRTIYS CDACRSRKIK CNRQTPCASC HKSKRDCVYT VSRQRDAQIT NRKLDKKTYH
QISAIEKKIS ALEGKKGLLQ VETINFNKSF TDQTPLVELQ SLFPYLLLSK QDPGCVLVRH
HCHHLLEKDP RYFEYSQLLA DLSLTKRHHL TARAKALLGE AYIPSPQEGH TIDQLKHVLS
LNPNFRFAGN FADPLTSFFS LIPPAWANKQ LVDTFFQHIY PVIPIIDETD FNTSINRVLG
PQIDGHYINS FPSIGSADDL PFLALFLLVL RISYMYTPGA CPVSYDTLRA AETIMKEFDI
TKTHSLTALQ AEIMLRFYKI VAPESYTQSN YVQVSVGVLI QNCYSLALHR DPEYIGEHNP
KQQHLRRKIW HLLLRMEVID SAIFQTILSS NPDASDTKLP QLIDQAPPME QSIVKHIWRS
TDLFVSLRKL VEINSKTSED TPLETVLELL VEVETKLQAF LATIDSEAST VFYNDLVIFS
VNFLLVYMYY SLYLFKGPTP LGNKYLLKSA QILFVDLART RSTSLFLAYF NLNYIHLVLM
ITNFLRMRVD CIIHRHLRAQ DSSVQDLQCC RYFLKIIFFS HVKELGNYSS SHKYAWQMRK
VYLTLAKIME RSSDVLISND PELVKSAAVD IPVKEINKLL EQYINFKGFT PTTLFDPTDN
ELIDEMQHEN LWNAMENIEY SEKVYSGWID AIKNVPSNWD WDYWDFLKIS


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