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pH-response transcription factor pacC/RIM101 (pH-response regulator protein 2)

 PACC_CANAL              Reviewed;         661 AA.
Q9UW14; A0A1D8PFX3; Q59ZU5;
21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
21-JUN-2005, sequence version 2.
22-NOV-2017, entry version 99.
RecName: Full=pH-response transcription factor pacC/RIM101;
AltName: Full=pH-response regulator protein 2;
Name=RIM101; Synonyms=HRM101, PRR2;
OrderedLocusNames=CAALFM_C114340CA; ORFNames=CaO19.7247;
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
Candida/Lodderomyces clade; Candida.
NCBI_TaxID=237561;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND MUTAGENESIS OF
463-SER--PHE-661.
STRAIN=SC5314 / CAI4 / ATCC MYA-682;
PubMed=10629054; DOI=10.1128/MCB.20.3.971-978.2000;
Davis D.A., Wilson R.B., Mitchell A.P.;
"RIM101-dependent and -independent pathways govern pH responses in
Candida albicans.";
Mol. Cell. Biol. 20:971-978(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=15123810; DOI=10.1073/pnas.0401648101;
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
Davis R.W., Scherer S.;
"The diploid genome sequence of Candida albicans.";
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
[3]
GENOME REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
Chibana H., Nantel A., Magee P.T.;
"Assembly of the Candida albicans genome into sixteen supercontigs
aligned on the eight chromosomes.";
Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
"Assembly of a phased diploid Candida albicans genome facilitates
allele-specific measurements and provides a simple model for repeat
and indel structure.";
Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
[5]
FUNCTION, AND INDUCTION.
PubMed=10601210;
Ramon A.M., Porta A., Fonzi W.A.;
"Effect of environmental pH on morphological development of Candida
albicans is mediated via the PacC-related transcription factor encoded
by PRR2.";
J. Bacteriol. 181:7524-7530(1999).
[6]
MUTAGENESIS OF 476-GLN--PHE-661 AND 584-SER--PHE-661.
PubMed=10848590; DOI=10.1128/MCB.20.13.4635-4647.2000;
El Barkani A., Kurzai O., Fonzi W.A., Ramon A.M., Porta A., Frosch M.,
Muehlschlegel F.A.;
"Dominant active alleles of RIM101 (PRR2) bypass the pH restriction on
filamentation of Candida albicans.";
Mol. Cell. Biol. 20:4635-4647(2000).
[7]
DNA-BINDING, AND FUNCTION IN TRANSCRIPTIONAL ACTIVATION.
PubMed=12912891; DOI=10.1128/EC.2.4.718-728.2003;
Ramon A.M., Fonzi W.A.;
"Diverged binding specificity of Rim101p, the Candida albicans
ortholog of PacC.";
Eukaryot. Cell 2:718-728(2003).
[8]
PROTEOLYTIC PROCESSING.
PubMed=15189995; DOI=10.1128/EC.3.3.741-751.2004;
Li M., Martin S.J., Bruno V.M., Mitchell A.P., Davis D.A.;
"Candida albicans Rim13p, a protease required for Rim101p processing
at acidic and alkaline pHs.";
Eukaryot. Cell 3:741-751(2004).
-!- FUNCTION: Transcription factor that mediates regulation of both
acid- and alkaline-expressed genes in response to ambient pH. At
alkaline ambient pH, activates transcription of alkaline-expressed
genes (including RIM101 itself) and represses transcription of
acid-expressed genes. Specifically recognizes and binds the
consensus sequence 5'-CCAAGAA-3'. Required for the control of
alkaline pH-induced filamentation (dimorphic switch) and
virulence. {ECO:0000269|PubMed:10601210,
ECO:0000269|PubMed:12912891}.
-!- SUBUNIT: Binds to DNA. Interacts with RIM20, which binds to the
YPX[LI] motifs and is required for proteolytic processing (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
{ECO:0000250}.
-!- INDUCTION: By alkaline conditions. {ECO:0000269|PubMed:10601210}.
-!- PTM: Activated by C-terminal proteolytic cleavage. At neutral to
alkaline ambient pH, the signaling protease (probably RIM13)
cleaves RIM101 to yield the 74 kDa functional form. Also exists as
a 65 kDa form at acidic pH, which may govern pH-independent
processes. {ECO:0000269|PubMed:15189995}.
-!- SIMILARITY: Belongs to the pacC/RIM101 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAD51714.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AF173841; AAD51714.1; ALT_INIT; Genomic_DNA.
EMBL; CP017623; AOW27034.1; -; Genomic_DNA.
RefSeq; XP_715047.1; XM_709954.1.
ProteinModelPortal; Q9UW14; -.
SMR; Q9UW14; -.
IntAct; Q9UW14; 1.
PRIDE; Q9UW14; -.
EnsemblFungi; AOW27034; AOW27034; CAALFM_C114340CA.
GeneID; 3643280; -.
KEGG; cal:CAALFM_C114340CA; -.
CGD; CAL0000174156; RIM101.
EuPathDB; FungiDB:C1_14340C_A; -.
InParanoid; Q9UW14; -.
OrthoDB; EOG092C1EDI; -.
Proteomes; UP000000559; Chromosome 1.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IDA:CGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0071469; P:cellular response to alkaline pH; IMP:CGD.
GO; GO:0071280; P:cellular response to copper ion; IMP:CGD.
GO; GO:0035690; P:cellular response to drug; IMP:CGD.
GO; GO:0010106; P:cellular response to iron ion starvation; IMP:CGD.
GO; GO:0071285; P:cellular response to lithium ion; IMP:CGD.
GO; GO:0036244; P:cellular response to neutral pH; IMP:CGD.
GO; GO:0071467; P:cellular response to pH; IDA:CGD.
GO; GO:0001410; P:chlamydospore formation; IMP:CGD.
GO; GO:0044409; P:entry into host; IMP:CGD.
GO; GO:0030447; P:filamentous growth; IMP:CGD.
GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
GO; GO:0036171; P:filamentous growth of a population of unicellular organisms in response to chemical stimulus; IMP:CGD.
GO; GO:0036178; P:filamentous growth of a population of unicellular organisms in response to neutral pH; IMP:CGD.
GO; GO:0036177; P:filamentous growth of a population of unicellular organisms in response to pH; IMP:CGD.
GO; GO:0044416; P:induction by symbiont of host defense response; IMP:CGD.
GO; GO:0009405; P:pathogenesis; IMP:CGD.
GO; GO:1900430; P:positive regulation of filamentous growth of a population of unicellular organisms; IMP:CGD.
GO; GO:1900439; P:positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus; IMP:CGD.
GO; GO:0002666; P:positive regulation of T cell tolerance induction; IMP:CGD.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:CGD.
GO; GO:0007165; P:signal transduction; IGI:CGD.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
SMART; SM00355; ZnF_C2H2; 3.
SUPFAM; SSF57667; SSF57667; 2.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
1: Evidence at protein level;
Coiled coil; Complete proteome; Cytoplasm; Metal-binding; Nucleus;
Reference proteome; Repeat; Repressor; Zinc; Zinc-finger.
CHAIN 1 661 pH-response transcription factor
pacC/RIM101.
/FTId=PRO_0000046824.
ZN_FING 208 233 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 244 268 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 274 296 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
COILED 626 654 {ECO:0000255}.
MOTIF 290 296 Nuclear localization signal.
MOTIF 498 501 YPX[LI] motif 1.
MOTIF 531 534 YPX[LI] motif 2.
MOTIF 655 658 YPX[LI] motif 3.
COMPBIAS 108 186 Gln-rich.
COMPBIAS 431 436 Poly-His.
COMPBIAS 438 496 Gln-rich.
MUTAGEN 463 661 Missing: In RIM101-405; is active
independent on proteolytic processing.
Allows filamentation at alkaline pH in
the absence of RIM13 or RIM8 and RIM20.
{ECO:0000269|PubMed:10629054}.
MUTAGEN 476 661 Missing: In CEM-1; dominant active allele
that allows filamentation, activates
alkaline-expressed and represses acid-
expressed genes at acidic pH.
{ECO:0000269|PubMed:10848590}.
MUTAGEN 584 661 Missing: In CEM-2; dominant active allele
that allows filamentation, activates
alkaline-expressed and represses acid-
expressed genes at acidic pH.
{ECO:0000269|PubMed:10848590}.
CONFLICT 401 407 AGSAEFT -> RRFWSSSP (in Ref. 1;
AAD51714). {ECO:0000305}.
SEQUENCE 661 AA; 74695 MW; B3C1C613CD8CAA95 CRC64;
MNYNIHPVTY LNADSNTGAS ESTASHHGSK KSPSSDIDVD NATSPSSFTS SQSPHINAMG
NSPHSSFTSQ SAANSPITDA KQHLVKPTTT KPAAFAPSAN QSNTTASQSY TQPAQQLPTQ
LHPSLNQAYN NQPSYYLHQP TYGYQQQQQQ QQQHQEFNQP SQQYHDHHGY YSNNNILNQN
QPAPQQNPVK PFKKTYKKIR DEDLKGPFKC LWSNCNIIFE TPEILYDHLC DDHVGRKSSN
NLSLTCLWEN CGTTTVKRDH ITSHLRVHVP LKPFHCDLCP KSFKRPQDLK KHSKTHAEDH
PKKLKKAQRE LMKQQQKEAK QQQKLANKRA NSMNATTASD LQLNYYSGNP ADGLNYDDTS
RKRRYENNSQ HNMYVVNSIL NDFNFQQMAQ APQQPGVVGT AGSAEFTTKR MKAGTEYNID
VFNKLNHLDD HLHHHHPQQQ HPQQQYGGNI YEAEKFFNSL SNSIDMQYQN MSTQYQQQHA
GSTFAQQKPT QQASGQLYPS LPTIGNGSYT TSGSSHKEGL VNNHNGYLPS YPQINRSLPY
SSGVAQQPPS ALEFGGVSTY QKSAQSYEED SSDSSEEDDY STSSEDELDT LFDKLNIDDN
KVEEVTIDGF NLKDVAKHRE MIHAVLGYLR NQIEQQEKEK SKEQKEVDVN ETKLYPTITA
F


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