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snRNA-activating protein complex subunit 1 (SNAPc subunit 1) (Proximal sequence element-binding transcription factor subunit gamma) (PSE-binding factor subunit gamma) (PTF subunit gamma) (Small nuclear RNA-activating complex polypeptide 1) (snRNA-activating protein complex 43 kDa subunit) (SNAPc 43 kDa subunit)

 SNPC1_HUMAN             Reviewed;         368 AA.
Q16533;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
25-OCT-2017, entry version 140.
RecName: Full=snRNA-activating protein complex subunit 1;
Short=SNAPc subunit 1;
AltName: Full=Proximal sequence element-binding transcription factor subunit gamma;
Short=PSE-binding factor subunit gamma;
Short=PTF subunit gamma;
AltName: Full=Small nuclear RNA-activating complex polypeptide 1;
AltName: Full=snRNA-activating protein complex 43 kDa subunit;
Short=SNAPc 43 kDa subunit;
Name=SNAPC1; Synonyms=SNAP43;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
PubMed=7715707; DOI=10.1038/374653a0;
Henry R.W., Sadowski C.L., Kobayashi R., Hernandez N.;
"A TBP-TAF complex required for transcription of human snRNA genes by
RNA polymerase II and III.";
Nature 374:653-656(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8524284; DOI=10.1128/MCB.16.1.1;
Yoon J.B., Roeder R.G.;
"Cloning of two proximal sequence element-binding transcription factor
subunits (gamma and delta) that are required for transcription of
small nuclear RNA genes by RNA polymerases II and III and interact
with the TATA-binding protein.";
Mol. Cell. Biol. 16:1-9(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney, and Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INTERACTION WITH SNAPC3 AND SNAPC4.
PubMed=11056176; DOI=10.1074/jbc.M009301200;
Ma B., Hernandez N.;
"A map of protein-protein contacts within the small nuclear RNA-
activating protein complex SNAPc.";
J. Biol. Chem. 276:5027-5035(2001).
[5]
FUNCTION, AND INTERACTION WITH SNAPC3 AND TBP.
PubMed=12621023; DOI=10.1074/jbc.M204247200;
Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.;
"The small nuclear RNA-activating protein 190 Myb DNA binding domain
stimulates TATA box-binding protein-TATA box recognition.";
J. Biol. Chem. 278:18649-18657(2003).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-290, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21406692; DOI=10.1126/scisignal.2001570;
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
Blagoev B.;
"System-wide temporal characterization of the proteome and
phosphoproteome of human embryonic stem cell differentiation.";
Sci. Signal. 4:RS3-RS3(2011).
-!- FUNCTION: Part of the SNAPc complex required for the transcription
of both RNA polymerase II and III small-nuclear RNA genes. Binds
to the proximal sequence element (PSE), a non-TATA-box basal
promoter element common to these 2 types of genes. Recruits TBP
and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}.
-!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3,
SNAPC4 and TBP. {ECO:0000269|PubMed:11056176,
ECO:0000269|PubMed:12621023}.
-!- SUBCELLULAR LOCATION: Nucleus.
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EMBL; Z47542; CAA87590.1; -; mRNA.
EMBL; U44754; AAC50358.1; -; mRNA.
EMBL; BC014984; AAH14984.1; -; mRNA.
EMBL; BC019038; AAH19038.1; -; mRNA.
CCDS; CCDS9755.1; -.
PIR; JC6081; JC6081.
RefSeq; NP_003073.1; NM_003082.3.
UniGene; Hs.179312; -.
ProteinModelPortal; Q16533; -.
BioGrid; 112501; 16.
CORUM; Q16533; -.
DIP; DIP-504N; -.
IntAct; Q16533; 1.
STRING; 9606.ENSP00000216294; -.
iPTMnet; Q16533; -.
PhosphoSitePlus; Q16533; -.
BioMuta; SNAPC1; -.
DMDM; 8134716; -.
EPD; Q16533; -.
MaxQB; Q16533; -.
PaxDb; Q16533; -.
PeptideAtlas; Q16533; -.
PRIDE; Q16533; -.
DNASU; 6617; -.
Ensembl; ENST00000216294; ENSP00000216294; ENSG00000023608.
GeneID; 6617; -.
KEGG; hsa:6617; -.
UCSC; uc001xft.3; human.
CTD; 6617; -.
DisGeNET; 6617; -.
EuPathDB; HostDB:ENSG00000023608.4; -.
GeneCards; SNAPC1; -.
HGNC; HGNC:11134; SNAPC1.
HPA; HPA029311; -.
MIM; 600591; gene.
neXtProt; NX_Q16533; -.
OpenTargets; ENSG00000023608; -.
PharmGKB; PA35982; -.
eggNOG; KOG4746; Eukaryota.
eggNOG; ENOG410Z6WG; LUCA.
GeneTree; ENSGT00390000018691; -.
HOGENOM; HOG000294209; -.
HOVERGEN; HBG058831; -.
InParanoid; Q16533; -.
KO; K15208; -.
OMA; SYRMKKK; -.
OrthoDB; EOG091G0R68; -.
PhylomeDB; Q16533; -.
TreeFam; TF324445; -.
Reactome; R-HSA-6807505; RNA polymerase II transcribes snRNA genes.
Reactome; R-HSA-749476; RNA Polymerase III Abortive And Retractive Initiation.
Reactome; R-HSA-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
ChiTaRS; SNAPC1; human.
GeneWiki; SNAPC1; -.
GenomeRNAi; 6617; -.
PRO; PR:Q16533; -.
Proteomes; UP000005640; Chromosome 14.
Bgee; ENSG00000023608; -.
CleanEx; HS_SNAPC1; -.
Genevisible; Q16533; HS.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0019185; C:snRNA-activating protein complex; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0042795; P:snRNA transcription from RNA polymerase II promoter; IBA:GO_Central.
GO; GO:0042796; P:snRNA transcription from RNA polymerase III promoter; IBA:GO_Central.
InterPro; IPR019188; SNAPc_SNAP43.
PANTHER; PTHR15131; PTHR15131; 1.
Pfam; PF09808; SNAPc_SNAP43; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; DNA-binding; Nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 368 snRNA-activating protein complex subunit
1.
/FTId=PRO_0000072017.
REGION 1 168 SNAPC3-binding.
REGION 164 268 SNAPC4-binding.
COMPBIAS 347 352 Poly-Glu.
MOD_RES 289 289 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 290 290 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692}.
SEQUENCE 368 AA; 42994 MW; 324E89CF8B540C32 CRC64;
MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE KNMFTKEALA
LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA LKDWDEVLKF QQDLVNAQHF
DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK KIHRAEVTEE FKDPSDRVMK LITSDVLEEM
LNVHDHYQNM KHVISVDKSK PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKTN
DGEEKMEGNS QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DSDSASGQGQ
VKATRKKEKK ERLKPAGRKM SLRNKGNVQN IHKEDKPLSL SMPVITEEEE NESLSGTEFT
ASKKRRKH


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