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snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE-binding factor subunit delta) (PTF subunit delta) (Small nuclear RNA-activating complex polypeptide 2) (snRNA-activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit)

 SNPC2_HUMAN             Reviewed;         334 AA.
Q13487; B2RBZ6; D6W663; Q13486;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
27-SEP-2017, entry version 139.
RecName: Full=snRNA-activating protein complex subunit 2;
Short=SNAPc subunit 2;
AltName: Full=Proximal sequence element-binding transcription factor subunit delta;
Short=PSE-binding factor subunit delta;
Short=PTF subunit delta;
AltName: Full=Small nuclear RNA-activating complex polypeptide 2;
AltName: Full=snRNA-activating protein complex 45 kDa subunit;
Short=SNAPc 45 kDa subunit;
Name=SNAPC2; Synonyms=SNAP45;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Teratocarcinoma;
PubMed=8633057; DOI=10.1073/pnas.93.9.4289;
Sadowski C.L., Henry R.W., Kobayashi R., Hernandez N.;
"The SNAP45 subunit of the small nuclear RNA (snRNA) activating
protein complex is required for RNA polymerase II and III snRNA gene
transcription and interacts with the TATA box binding protein.";
Proc. Natl. Acad. Sci. U.S.A. 93:4289-4293(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8524284; DOI=10.1128/MCB.16.1.1;
Yoon J.B., Roeder R.G.;
"Cloning of two proximal sequence element-binding transcription factor
subunits (gamma and delta) that are required for transcription of
small nuclear RNA genes by RNA polymerases II and III and interact
with the TATA-binding protein.";
Mol. Cell. Biol. 16:1-9(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-118.
TISSUE=Lung;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-118.
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
INTERACTION WITH SNAPC4.
PubMed=9418884; DOI=10.1128/MCB.18.1.368;
Wong M.W., Henry R.W., Ma B., Kobayashi R., Klages N., Matthias P.,
Strubin M., Hernandez N.;
"The large subunit of basal transcription factor SNAPc is a Myb domain
protein that interacts with Oct-1.";
Mol. Cell. Biol. 18:368-377(1998).
[7]
INTERACTION WITH TBP.
PubMed=12621023; DOI=10.1074/jbc.M204247200;
Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.;
"The small nuclear RNA-activating protein 190 Myb DNA binding domain
stimulates TATA box-binding protein-TATA box recognition.";
J. Biol. Chem. 278:18649-18657(2003).
-!- FUNCTION: Part of the SNAPc complex required for the transcription
of both RNA polymerase II and III small-nuclear RNA genes. Binds
to the proximal sequence element (PSE), a non-TATA-box basal
promoter element common to these 2 types of genes. Recruits TBP
and BRF2 to the U6 snRNA TATA box.
-!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and
SNAPC4. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}.
-!- SUBCELLULAR LOCATION: Nucleus.
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EMBL; U44898; AAB06230.1; -; mRNA.
EMBL; U44755; AAC50359.1; -; mRNA.
EMBL; AK314878; BAG37393.1; -; mRNA.
EMBL; CH471139; EAW68957.1; -; Genomic_DNA.
EMBL; CH471139; EAW68958.1; -; Genomic_DNA.
EMBL; BC011868; AAH11868.1; -; mRNA.
CCDS; CCDS12190.1; -.
PIR; JC6082; JC6082.
RefSeq; NP_003074.1; NM_003083.3.
UniGene; Hs.631860; -.
ProteinModelPortal; Q13487; -.
SMR; Q13487; -.
BioGrid; 112502; 6.
CORUM; Q13487; -.
DIP; DIP-505N; -.
IntAct; Q13487; 1.
STRING; 9606.ENSP00000221573; -.
iPTMnet; Q13487; -.
PhosphoSitePlus; Q13487; -.
BioMuta; SNAPC2; -.
DMDM; 8134714; -.
EPD; Q13487; -.
MaxQB; Q13487; -.
PaxDb; Q13487; -.
PeptideAtlas; Q13487; -.
PRIDE; Q13487; -.
DNASU; 6618; -.
Ensembl; ENST00000221573; ENSP00000221573; ENSG00000104976.
GeneID; 6618; -.
KEGG; hsa:6618; -.
UCSC; uc002miw.3; human.
CTD; 6618; -.
EuPathDB; HostDB:ENSG00000104976.11; -.
GeneCards; SNAPC2; -.
HGNC; HGNC:11135; SNAPC2.
HPA; HPA049843; -.
MIM; 605076; gene.
neXtProt; NX_Q13487; -.
OpenTargets; ENSG00000104976; -.
PharmGKB; PA35983; -.
eggNOG; ENOG410IX3I; Eukaryota.
eggNOG; ENOG410YPM6; LUCA.
GeneTree; ENSGT00390000017407; -.
HOGENOM; HOG000132929; -.
HOVERGEN; HBG079198; -.
InParanoid; Q13487; -.
KO; K15209; -.
OMA; VEHMTET; -.
OrthoDB; EOG091G0O5J; -.
PhylomeDB; Q13487; -.
TreeFam; TF336993; -.
Reactome; R-HSA-6807505; RNA polymerase II transcribes snRNA genes.
Reactome; R-HSA-749476; RNA Polymerase III Abortive And Retractive Initiation.
Reactome; R-HSA-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
GeneWiki; SNAPC2; -.
GenomeRNAi; 6618; -.
PRO; PR:Q13487; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000104976; -.
CleanEx; HS_SNAPC2; -.
ExpressionAtlas; Q13487; baseline and differential.
Genevisible; Q13487; HS.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0016604; C:nuclear body; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; TAS:ProtInc.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; TAS:ProtInc.
GO; GO:0009301; P:snRNA transcription; TAS:ProtInc.
GO; GO:0042795; P:snRNA transcription from RNA polymerase II promoter; TAS:Reactome.
GO; GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc.
GO; GO:0006383; P:transcription from RNA polymerase III promoter; TAS:ProtInc.
InterPro; IPR021281; SnAPC_su2-like.
PANTHER; PTHR15132; PTHR15132; 1.
Pfam; PF11035; SnAPC_2_like; 1.
1: Evidence at protein level;
Complete proteome; Nucleus; Polymorphism; Reference proteome;
Transcription; Transcription regulation.
CHAIN 1 334 snRNA-activating protein complex subunit
2.
/FTId=PRO_0000072020.
VARIANT 118 118 L -> V (in dbSNP:rs475002).
{ECO:0000269|PubMed:14702039,
ECO:0000269|Ref.4}.
/FTId=VAR_011806.
SEQUENCE 334 AA; 35556 MW; 441894AF6E1F4083 CRC64;
MKPPPRRRAA PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL ARELRGRSEA
EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI EVWTDLAEKI TGPLEEALAV
AFSQVLTIAA TEPVTLLHSK PPKPTQARGK PLLLSAPGGQ EDPAPEIPSS APAAPSSAPR
TPDPAPEKPS ESSAGPSTEE DFAVDFEKIY KYLSSVSRSG RSPELSAAES AVVLDLLMSL
PEELPLLPCT ALVEHMTETY LRLTAPQPIP AGGSLGPAAE GDGAGSKAPE ETPPATEKAE
HSELKSPWQA AGICPLNPFL VPLELLGRAA TPAR


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