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snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Proximal sequence element-binding transcription factor subunit beta) (PSE-binding factor subunit beta) (PTF subunit beta) (Small nuclear RNA-activating complex polypeptide 3) (snRNA-activating protein complex 50 kDa subunit) (SNAPc 50 kDa subunit)

 SNPC3_HUMAN             Reviewed;         411 AA.
Q92966; D3DRI8; Q2VPI6; Q5T285;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
12-SEP-2018, entry version 148.
RecName: Full=snRNA-activating protein complex subunit 3;
Short=SNAPc subunit 3;
AltName: Full=Proximal sequence element-binding transcription factor subunit beta;
Short=PSE-binding factor subunit beta;
Short=PTF subunit beta;
AltName: Full=Small nuclear RNA-activating complex polypeptide 3;
AltName: Full=snRNA-activating protein complex 50 kDa subunit;
Short=SNAPc 50 kDa subunit;
Name=SNAPC3; Synonyms=SNAP50;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Teratocarcinoma;
PubMed=9003788;
Henry R.W., Ma B., Sadowski C.L., Kobayashi R., Hernandez N.;
"Cloning and characterization of SNAP50, a subunit of the snRNA-
activating protein complex SNAPc.";
EMBO J. 15:7129-7136(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8816454; DOI=10.1128/MCB.16.10.5419;
Bai L., Wang Z., Yoon J.B., Roeder R.G.;
"Cloning and characterization of the beta subunit of human proximal
sequence element-binding transcription factor and its involvement in
transcription of small nuclear RNA genes by RNA polymerases II and
III.";
Mol. Cell. Biol. 16:5419-5426(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164053; DOI=10.1038/nature02465;
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
Rogers J., Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
INTERACTION WITH SNAPC1.
PubMed=11056176; DOI=10.1074/jbc.M009301200;
Ma B., Hernandez N.;
"A map of protein-protein contacts within the small nuclear RNA-
activating protein complex SNAPc.";
J. Biol. Chem. 276:5027-5035(2001).
[7]
FUNCTION, AND INTERACTION WITH SNAPC1.
PubMed=12621023; DOI=10.1074/jbc.M204247200;
Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.;
"The small nuclear RNA-activating protein 190 Myb DNA binding domain
stimulates TATA box-binding protein-TATA box recognition.";
J. Biol. Chem. 278:18649-18657(2003).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic kidney;
PubMed=17525332; DOI=10.1126/science.1140321;
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,
Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,
Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks
responsive to DNA damage.";
Science 316:1160-1166(2007).
-!- FUNCTION: Part of the SNAPc complex required for the transcription
of both RNA polymerase II and III small-nuclear RNA genes. Binds
to the proximal sequence element (PSE), a non-TATA-box basal
promoter element common to these 2 types of genes. Recruits TBP
and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}.
-!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
{ECO:0000269|PubMed:11056176, ECO:0000269|PubMed:12621023}.
-!- INTERACTION:
Q8IYX8:CEP57L1; NbExp=3; IntAct=EBI-1760638, EBI-1104570;
Q8IYX8-2:CEP57L1; NbExp=3; IntAct=EBI-1760638, EBI-10181988;
Q9BPX1:HSD17B14; NbExp=3; IntAct=EBI-1760638, EBI-742664;
Q8NI38:NFKBID; NbExp=4; IntAct=EBI-1760638, EBI-10271199;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the SNAPC3/SRD2 family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; U71300; AAC50948.1; -; mRNA.
EMBL; U66413; AAD09214.1; -; mRNA.
EMBL; AL441925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471071; EAW58681.1; -; Genomic_DNA.
EMBL; CH471071; EAW58682.1; -; Genomic_DNA.
EMBL; BC014985; AAH14985.1; -; mRNA.
EMBL; BC108743; AAI08744.1; -; mRNA.
EMBL; BC121011; AAI21012.1; -; mRNA.
EMBL; BC121012; AAI21013.1; -; mRNA.
CCDS; CCDS6478.1; -.
RefSeq; NP_001034786.1; NM_001039697.1.
RefSeq; XP_016870545.1; XM_017015056.1.
RefSeq; XP_016870546.1; XM_017015057.1.
UniGene; Hs.546299; -.
ProteinModelPortal; Q92966; -.
BioGrid; 112503; 8.
CORUM; Q92966; -.
IntAct; Q92966; 15.
MINT; Q92966; -.
STRING; 9606.ENSP00000370200; -.
iPTMnet; Q92966; -.
PhosphoSitePlus; Q92966; -.
BioMuta; SNAPC3; -.
DMDM; 8134719; -.
EPD; Q92966; -.
MaxQB; Q92966; -.
PaxDb; Q92966; -.
PeptideAtlas; Q92966; -.
PRIDE; Q92966; -.
ProteomicsDB; 75633; -.
DNASU; 6619; -.
Ensembl; ENST00000380821; ENSP00000370200; ENSG00000164975.
Ensembl; ENST00000467062; ENSP00000436699; ENSG00000164975.
Ensembl; ENST00000490969; ENSP00000432393; ENSG00000164975.
Ensembl; ENST00000610884; ENSP00000483273; ENSG00000164975.
GeneID; 6619; -.
KEGG; hsa:6619; -.
UCSC; uc003zlt.4; human.
CTD; 6619; -.
EuPathDB; HostDB:ENSG00000164975.15; -.
GeneCards; SNAPC3; -.
HGNC; HGNC:11136; SNAPC3.
HPA; HPA053145; -.
HPA; HPA066031; -.
MIM; 602348; gene.
neXtProt; NX_Q92966; -.
OpenTargets; ENSG00000164975; -.
PharmGKB; PA35984; -.
eggNOG; KOG2664; Eukaryota.
eggNOG; ENOG411090A; LUCA.
GeneTree; ENSGT00390000005708; -.
HOGENOM; HOG000146435; -.
HOVERGEN; HBG071400; -.
InParanoid; Q92966; -.
KO; K15210; -.
OMA; QTAKMED; -.
OrthoDB; EOG091G0BC6; -.
PhylomeDB; Q92966; -.
TreeFam; TF317705; -.
Reactome; R-HSA-6807505; RNA polymerase II transcribes snRNA genes.
Reactome; R-HSA-749476; RNA Polymerase III Abortive And Retractive Initiation.
Reactome; R-HSA-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
ChiTaRS; SNAPC3; human.
GeneWiki; SNAPC3; -.
GenomeRNAi; 6619; -.
PRO; PR:Q92966; -.
Proteomes; UP000005640; Chromosome 9.
Bgee; ENSG00000164975; Expressed in 228 organ(s), highest expression level in testis.
CleanEx; HS_SNAPC3; -.
ExpressionAtlas; Q92966; baseline and differential.
Genevisible; Q92966; HS.
GO; GO:0016604; C:nuclear body; IDA:HPA.
GO; GO:0005730; C:nucleolus; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; IDA:HPA.
GO; GO:0003677; F:DNA binding; IBA:GO_Central.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0009301; P:snRNA transcription; TAS:ProtInc.
GO; GO:0042795; P:snRNA transcription by RNA polymerase II; TAS:Reactome.
GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc.
GO; GO:0006383; P:transcription by RNA polymerase III; TAS:ProtInc.
InterPro; IPR022042; snRNA-activating_su3.
PANTHER; PTHR13421; PTHR13421; 1.
Pfam; PF12251; zf-SNAP50_C; 1.
1: Evidence at protein level;
Complete proteome; DNA-binding; Nucleus; Polymorphism;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 411 snRNA-activating protein complex subunit
3.
/FTId=PRO_0000072024.
VARIANT 398 398 E -> A (in dbSNP:rs3087653).
/FTId=VAR_051366.
SEQUENCE 411 AA; 46753 MW; 920584BE4CFA366A CRC64;
MAEGSRGGPT CSGVGGRQDP VSGSGGCNFP EYELPELNTR AFHVGAFGEL WRGRLRGAGD
LSLREPPASA LPGSQAADSD REDAAVARDL DCSLEAAAEL RAVCGLDKLK CLEDGEDPEV
IPENTDLVTL GVRKRFLEHR EETITIDRAC RQETFVYEME SHAIGKKPEN SADMIEEGEL
ILSVNILYPV IFHKHKEHKP YQTMLVLGSQ KLTQLRDSIR CVSDLQIGGE FSNTPDQAPE
HISKDLYKSA FFYFEGTFYN DKRYPECRDL SRTIIEWSES HDRGYGKFQT ARMEDFTFND
LCIKLGFPYL YCHQGDCEHV IVITDIRLVH HDDCLDRTLY PLLIKKHWLW TRKCFVCKMY
TARWVTNNDS FAPEDPCFFC DVCFRMLHYD SEGNKLGEFL AYPYVDPGTF N


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