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tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5)

 A0A0L6WZR2_9AGAR        Unreviewed;      1132 AA.
A0A0L6WZR2;
11-NOV-2015, integrated into UniProtKB/TrEMBL.
11-NOV-2015, sequence version 1.
05-DEC-2018, entry version 22.
RecName: Full=tRNA (guanine(37)-N1)-methyltransferase {ECO:0000256|HAMAP-Rule:MF_03152};
EC=2.1.1.228 {ECO:0000256|HAMAP-Rule:MF_03152};
AltName: Full=M1G-methyltransferase {ECO:0000256|HAMAP-Rule:MF_03152};
AltName: Full=tRNA [GM37] methyltransferase {ECO:0000256|HAMAP-Rule:MF_03152};
AltName: Full=tRNA methyltransferase 5 {ECO:0000256|HAMAP-Rule:MF_03152};
Name=TRM5 {ECO:0000256|HAMAP-Rule:MF_03152};
ORFNames=J132_04887 {ECO:0000313|EMBL:KNZ80644.1};
Termitomyces sp. J132.
Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
Agaricomycetes; Agaricomycetidae; Agaricales; Lyophyllaceae;
Termitomyces.
NCBI_TaxID=1306850 {ECO:0000313|EMBL:KNZ80644.1, ECO:0000313|Proteomes:UP000053712};
[1] {ECO:0000313|Proteomes:UP000053712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=J132 {ECO:0000313|Proteomes:UP000053712};
Hu H., Poulsen M.;
"The genome of Termitomyces.";
Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Specifically methylates the N1 position of guanosine-37
in various cytoplasmic and mitochondrial tRNAs. Methylation is not
dependent on the nature of the nucleoside 5' of the target
nucleoside. This is the first step in the biosynthesis of
wybutosine (yW), a modified base adjacent to the anticodon of
tRNAs and required for accurate decoding. {ECO:0000256|HAMAP-
Rule:MF_03152}.
-!- CATALYTIC ACTIVITY:
Reaction=guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) +
N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine;
Xref=Rhea:RHEA:36899, Rhea:RHEA-COMP:10145, Rhea:RHEA-
COMP:10147, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
ChEBI:CHEBI:59789, ChEBI:CHEBI:73542, ChEBI:CHEBI:74269;
EC=2.1.1.228; Evidence={ECO:0000256|HAMAP-Rule:MF_03152,
ECO:0000256|SAAS:SAAS00165815};
-!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_03152,
ECO:0000256|SAAS:SAAS00165808}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03152,
ECO:0000256|SAAS:SAAS00534542}. Mitochondrion matrix
{ECO:0000256|HAMAP-Rule:MF_03152}. Nucleus {ECO:0000256|HAMAP-
Rule:MF_03152, ECO:0000256|SAAS:SAAS00534555}. Note=Predominantly
in the mitochondria and in the nucleus. {ECO:0000256|HAMAP-
Rule:MF_03152}.
-!- SIMILARITY: Belongs to the TRM5 / TYW2 family. {ECO:0000256|HAMAP-
Rule:MF_03152}.
-!- SIMILARITY: Belongs to the class I-like SAM-binding
methyltransferase superfamily. TRM5/TYW2 family.
{ECO:0000256|SAAS:SAAS00534547}.
-!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29)
family. {ECO:0000256|RuleBase:RU000488,
ECO:0000256|SAAS:SAAS00548220}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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EMBL; KQ412229; KNZ80644.1; -; Genomic_DNA.
EnsemblFungi; KNZ80644; KNZ80644; J132_04887.
Proteomes; UP000053712; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
GO; GO:0052906; F:tRNA (guanine(37)-N(1))-methyltransferase activity; IEA:UniProtKB-EC.
Gene3D; 1.50.40.10; -; 1.
HAMAP; MF_03152; TRM5; 1.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR018247; EF_Hand_1_Ca_BS.
InterPro; IPR002048; EF_hand_dom.
InterPro; IPR030382; MeTrfase_TRM5/TYW2.
InterPro; IPR002067; Mit_carrier.
InterPro; IPR040062; Mitochondrial_carrier_protein.
InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
InterPro; IPR023395; Mt_carrier_dom_sf.
InterPro; IPR029063; SAM-dependent_MTases.
InterPro; IPR025792; tRNA_Gua_MeTrfase_euk.
PANTHER; PTHR24089; PTHR24089; 1.
Pfam; PF00036; EF-hand_1; 1.
Pfam; PF13833; EF-hand_8; 1.
Pfam; PF02475; Met_10; 1.
Pfam; PF00153; Mito_carr; 3.
PRINTS; PR00926; MITOCARRIER.
SMART; SM00054; EFh; 2.
SUPFAM; SSF103506; SSF103506; 1.
SUPFAM; SSF47473; SSF47473; 2.
SUPFAM; SSF53335; SSF53335; 1.
PROSITE; PS00018; EF_HAND_1; 1.
PROSITE; PS50222; EF_HAND_2; 2.
PROSITE; PS51684; SAM_MT_TRM5_TYW2; 1.
PROSITE; PS50920; SOLCAR; 3.
3: Inferred from homology;
Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
Complete proteome {ECO:0000313|Proteomes:UP000053712};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03152,
ECO:0000256|SAAS:SAAS00494912};
Membrane {ECO:0000256|SAAS:SAAS00013441};
Methyltransferase {ECO:0000256|HAMAP-Rule:MF_03152,
ECO:0000256|SAAS:SAAS00494913};
Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03152,
ECO:0000256|SAAS:SAAS00494910};
Nucleus {ECO:0000256|HAMAP-Rule:MF_03152,
ECO:0000256|SAAS:SAAS00165814};
Reference proteome {ECO:0000313|Proteomes:UP000053712};
Repeat {ECO:0000256|SAAS:SAAS01075419};
S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_03152,
ECO:0000256|SAAS:SAAS00415313};
Transferase {ECO:0000256|HAMAP-Rule:MF_03152,
ECO:0000256|SAAS:SAAS00494913};
Transmembrane {ECO:0000256|SAAS:SAAS00013441};
Transmembrane helix {ECO:0000256|SAAS:SAAS00013441};
Transport {ECO:0000256|RuleBase:RU000488,
ECO:0000256|SAAS:SAAS01075442};
tRNA processing {ECO:0000256|HAMAP-Rule:MF_03152,
ECO:0000256|SAAS:SAAS00494919}.
DOMAIN 140 449 SAM_MT_TRM5_TYW2.
{ECO:0000259|PROSITE:PS51684}.
DOMAIN 539 574 EF-hand. {ECO:0000259|PROSITE:PS50222}.
DOMAIN 611 646 EF-hand. {ECO:0000259|PROSITE:PS50222}.
REPEAT 776 866 Solcar. {ECO:0000256|PROSITE-
ProRule:PRU00282}.
REPEAT 875 962 Solcar. {ECO:0000256|PROSITE-
ProRule:PRU00282}.
REPEAT 973 1064 Solcar. {ECO:0000256|PROSITE-
ProRule:PRU00282}.
CA_BIND 552 563 {ECO:0000256|PROSITE-ProRule:PRU00448}.
REGION 267 268 S-adenosyl-L-methionine binding.
{ECO:0000256|HAMAP-Rule:MF_03152}.
REGION 295 296 S-adenosyl-L-methionine binding.
{ECO:0000256|HAMAP-Rule:MF_03152}.
BINDING 229 229 S-adenosyl-L-methionine.
{ECO:0000256|HAMAP-Rule:MF_03152}.
BINDING 354 354 S-adenosyl-L-methionine.
{ECO:0000256|HAMAP-Rule:MF_03152}.
SEQUENCE 1132 AA; 127431 MW; 9C866BAD458310EB CRC64;
MSRKLTLDLT PPDWTDVPTI TVFDRKAFTK SFDILAVRAP VSKISTILRA PEMKGSLLDI
PKVHSVDVDP QNPQSHRLVL LKAATKTEVP EKVVNFLETQ TGSNELVPYT MTLDYDHWTA
EEIIRAVMPR HLKNGAPSGF AITGHIAHVN LTDDYLSYRK LIGQIILDKN KAIRTVVNKL
DSIHSVFRFF EMDLIAGEPD FVVEHSESDC TFTFDFREVY WNSRLHTEHA RLVQLFNPDD
VVADVFAGVG PFAVPSAKRG CAVFANDLNP NSTKYLKINV EKNGVDPFVR VSCEDGRDFI
RSVFRRSFED PFPALRGPRL SKTQERRIKK AGLYEPPTVT DAPPRRRISH VVMNLPDIAI
TFLDAFRGIL VSDEVPGLRE IYDVMPMIHC HCFTRELDPK KAEVDIRKRV ERRLGASLTA
DFYLHWRTRL IMAPLPNVDG DSERGSSLTR SALKTVRTAL DVPERELARW RRIFDANAKV
IDGEKYLDPE SFVNAIAPSG DLTKIGRAQF ALLFRVADAS RRGLVSWDDF TVFETLLKRP
DADYWMAFQY FDVDHDGYIT FNEFKNVFTA NVGPDAIPFD FDCDWVKLYL GKKNGTHVLG
YNEFTQLMKG LQGERLRQAF KYLDADQDGF IRPDQFKHII LEIAGHKLSQ AVIERLPTLC
TLTPGQRISY SEVVAFHNVV REMDMVERII REATAKSKDG RIDQSDFLNH ASSSSRYSLF
TPMEASIIFH FASRGVANSR LALIDFAQFL DPRWRAPHED AEFQVNTSKS LLSSVLASSY
NFVLGGFAGA FGATIVYPID MVKTRMQNQR STVVGQLLYK NSLDCARKIF RNEGFLGFYR
GLGPQLVGVA PEKAIKLTVN DLIRGRATDP ETGRIKLYWE LVAGGTAGGC QVVFTNPLEI
VKIRLQIQGE AAKAEGAVPK GAIHIIRQLG VFGLYKGASA CLLRDIPFSA IYFPAYWHLK
KDLFQEGYNG KQLSFFETLA AAGIAGMPAA YFTTPADVVK TRLQVEARQG QTNYKGLRDA
FIKIYKEEGF RALFKGGPAR IVRSSPQFGF TLLDCIGYET LKTYLPYPWE DKPRKVETAL
TSRPDDLSKI RARNALRILL DVHGDFGRKV AASGVPLSLS SPRLSAQLGR EK


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