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Index / ABM / p21 Antibody / Product Detail : Y058132 p21 Antibody
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Oct
23th

#Y058132 p21 Antibody

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  Price : 190   EUR
216   USD
147   GBP
799   Zloty
25478   JPY
1468   NOK
1573   SEK
215   CHF

Product name : p21 Antibody

Catalog number : Y058132

Quantity: 100ul

Availability: Yes

Supplier name : ABM

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About this Product :

p21 Antibody antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of p21 Antibody.
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More Details about

Antibody Type Primary Antibody
Accession # NM_000389.3
Description p21 is a This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
   
   
Immunogen Synthetic peptide conjugated to KLH
Species Reactivity Human
Specificity Not yet tested in other species.
Tested Applications Peptide ELISA, WB, IHC
Application Notes For research use only Peptide ELISA titer: 1:20,000-1ï¼?0,000 Western blot analysis: 1:200-1000 Immunohistochemistry: 1:50-200 Optimal dilutions/concentrations should be determined by the end use.
Raised In Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Purity Affinity purified
Storage Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Formulation Liquid
Concentration 100ug/100ul
Storage Store at -20°C/1 year
References Azzato,E.M., Driver,K.E., Lesueur,F., et al. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (er) Breast Cancer Res. 10 (3), R47 (2008).
Caution p21 is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.

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