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Index / ABM / Anti-ADAM-33 A Disintegrin And Metalloproteinase-33; Cytoplasmic domain antibody / Product Detail : Y051519 Anti-ADAM-33 A Disintegrin And Metalloproteinase-33; Cytoplasmic domain antibody
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Oct
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#Y051519 Anti-ADAM-33 A Disintegrin And Metalloproteinase-33; Cytoplasmic domain antibody

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  Price : 1208   EUR
1371   USD
937   GBP
5073   Zloty
161605   JPY
9314   NOK
9980   SEK
1366   CHF

Product name : Anti-ADAM-33 A Disintegrin And Metalloproteinase-33; Cytoplasmic domain antibody

Catalog number : Y051519

Quantity: 250ug

Availability: Yes

Supplier name : ABM

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About this Product :

Anti-ADAM-33 A Disintegrin And Metalloproteinase-33; Cytoplasmic domain antibody antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Anti-ADAM-33 A Disintegrin And Metalloproteinase-33; Cytoplasmic domain antibody.
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Anti-ADAM-33 A Disintegrin And Metalloproteinase-33; Cytoplasmic domain antibody storing antibdies for longer storage periods of the Anti-ADAM-33 A Disintegrin And Metalloproteinase-33; Cytoplasmic domain antibody we recommend - 21C or lower and for short periods lees than 1 month we suggest +5C fridge temperatures.
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More Details about

Antibody Type Primary Antibody
Description Anti-ADAM-33 (A Disintegrin And Metalloproteinase-33); Cytoplasmic domain is a The antibody is a polyclonal antibody made to the metalloproteinase ADAM-33. The antibody is made to a synthetic peptide based on cytoplasmic domain of human ADAM-33. The antibody has been peptide-affinity purified, concentrated to 1.0 mg/ml, with the addition of 0.05% sodium azide as preservative and 50% glycerol as cryoprotectant. ADAM-33 was first described from mouse brain, as an ADAM protease containing the conserved disintegrin domains found in other family members. Both human and mouse ADAM-33 were cloned, and have relatively high identity (71%), but lower identity (37%) with xenopus ADAM-13 (thought to be a species orthologue). ADAM-33 maps to chromosome 20 in humans and to chromosome 2 in mouse. A second sequence, alternatively spliced, has been reported for both human and mouse ADAM-33. The smaller sequence lacks exon #17, leading to a shorter EGF-like domain. ADAM-33 appears to be widely expressed, found in most organs analyzed. Testis showed a smaller message than other tissues, and may represent a truncated form of ADAM-33. ADAM-33 does not contain SH3 ligand domains in the Cytoplasmic portion, as ADAM-13 does, and thus may be differently regulated. ADAM-33 may also act as a cell-attachment molecule, by binding integrins through the cysteine-rich domain. Other ADAMs family members (ADAM-10, ADAM-17) have been more thoroughly studied, and are known to play key roles in inflammation, growth factor maturation and release, and a wide range of other functions. Recent work suggests that mutations in ADAM-33 may be linked to asthma; indeed, many of the mutations generate new cysteine residues, which may well disturb ADAM-33 function. ADAM-33 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, as well as disintegrin, cysteine-rich, EGF-like, transmembrane and Cytoplasmic domains. The full length human ADAM-33 sequence codes for a 813 amino acid protein, with predicted mass of 87.739kD, but glycosylation and cyteine-rich regions give ADAM-33 an apparent MW of 99 kD on reduced SDS PAGE gels. The smaller sequence is 728 AA, predicting a 78.319 kD zymogen. Mouse sequences are 797 and 685 AA, predicting 87.009 and 74.719 kD proteins, respectively, before posttranslational modifications. ADAM-33 contains a putative furin cleavage site, suggesting that a prohormone convertase cleaves the propeptide domain away from the catalytic domain. RP3-ADAM-33 recognizes bands of 99 kD (minor band), 58 kD (major band), and cleaved products_recover in reduced Western blots of cell lysates. A recommended starting concentration for Western blots is 1:1,000 when using colorimetric substrates such as BCIP/NBT, and 1:5,000 for chemiluminescent substrates. Higher concentrations of antibody may be needed for samples from more distantly related species. FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.
Immunogen Synthetic peptide from Human ADAM33 based on the cytoplasmic domain.
Species Reactivity Human
Tested Applications Recommended dilutions ICC/IF: Use at an assay dependent dilution. IHC-R: Use at an assay dependent dilution. WB: 1:1000. Detects a band of approximately 99 kDa (minor form), due to glycosylation and cysteine rich regions, and a band at 58 kDa (major band), under reducing conditions. (Predicted molecular weight: 88 kDa). Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Raised In Rabbit
Clonality Polyclonal
Isotype IgG
Purity Immunogen Affinity purified
Storage Buffer PBS, pH 7.4 with 0.05% sodium azide.
Formulation Liquid
Concentration 1ug/ul
Storage The undiluted antibody solution is stable for approximately 6 months at 4 ° C.For longer storage, store at -20 ° C.
Caution Anti-ADAM-33 (A Disintegrin And Metalloproteinase-33); Cytoplasmic domain is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.

 

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