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Index / ABM / to ADAMTS-1 A Disintigrin And Metalloproteinase with ThromboSpondin-1 motif METH-1; Carboxyterminal end antibody / Product Detail : Y051520 to ADAMTS-1 A Disintigrin And Metalloproteinase with ThromboSpondin-1 motif METH-1; Carboxyterminal end antibody
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Nov
19th

#Y051520 to ADAMTS-1 A Disintigrin And Metalloproteinase with ThromboSpondin-1 motif METH-1; Carboxyterminal end antibody

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  Price : 1208   EUR
1371   USD
937   GBP
5073   Zloty
161605   JPY
9314   NOK
9980   SEK
1366   CHF

Product name : to ADAMTS-1 A Disintigrin And Metalloproteinase with ThromboSpondin-1 motif METH-1; Carboxyterminal end antibody

Catalog number : Y051520

Quantity: 250ug

Availability: Yes

Supplier name : ABM

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to ADAMTS-1 A Disintigrin And Metalloproteinase with ThromboSpondin-1 motif METH-1; Carboxyterminal end antibody antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of to ADAMTS-1 A Disintigrin And Metalloproteinase with ThromboSpondin-1 motif METH-1; Carboxyterminal end antibody.
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More Details about

Antibody Type Primary Antibody
Description to ADAMTS-1 (A Disintigrin And Metalloproteinase with ThromboSpondin-1 motif, METH-1); Carboxyterminal end is a The antibody is a polyclonal antibody made to the metalloproteinase ADAMTS-1. The antibody is made to a synthetic peptide based on the carboxy end of human ADAMTS-1. The antibody has been peptide-affinity purified, concentrated to 1.0 mg/ml, with the addition of 0.05% sodium azide as preservative and 50% glycerol as cryoprotectant. ADAMTS-1, also known as METH-1, was first described as a protein elevated in invasive mouse tumors. Initial observations indicated a role for ADAMTS-1 in tumor progression, since the protein was preferentially expressed in more invasive tumor cell lines. Induction of ADAMTS-1 by LPS in mouse suggested the possibility that ADAMTS-1 could be involved in inflammation. ADAMTS-1 is also elevated in ovulation, where the expression seems to be under hormonal regulation. ADAMTS-1 has also been implicated in arthritis, possibly due to the turnover of aggrecan. ADAMTS-1 was also identified in mouse heart and kidney, and the human ortholog, METH-1, was found in heart, kidney, adrenal gland, thymus, liver, and skeletal muscle. A knockout mouse lacking ADAMTS-1 was found to have numerous developmental defects. A member of the metalloproteinase family containing disintegrin-like domains (ADAMs), the function of ADAMTS-1 is still poorly understood. ADAMTS-1 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active, cleaving aggrecan. In addition to the metalloprotease domain, ADAMTS-1 has a propeptide domain, two Prohormone Convertase (PC, furin) cleavage sites, a cysteine-rich domain and three thrombospondin-1 like domains. The ADAMTS proteins do not have a transmembrane domain, unlike the ADAMs proteases, and are secreted proteins. ADAMTS-1 is thought to be preferentially secreted into the ECM, where it binds via the thrombospondin motifs to the ECM. The full length ADAMTS-1 sequence codes for a 967 amino acid protein, with a predicted mass of 105.383 kD, but glycosylation and the abundance of cysteine residues gives ADAMTS-1 a greater apparent molecular weight on reduced SDS PAGE gels. ADAMTS-1 is cleaved by furin or other prohormone convertases at one or both of the furin consensus sites in the amino portion of the molecule, producing the proteolytically active form. A second cleavage by a metalloproteinase is thought to yield a shed form of ADAMTS-1, releasing it from the ECM by cleavage between the first and second thrombospondin motifs. RP1-ADAMTS-1 recognizes the zymogen of ADAMTS-1, and the furin cleaved ADAMTS-1, but not the shed form. A recommended starting concentration for Western blots is 1:1,000 when using colorimetric substrates such as BCIP/NBT, and 1:5,000 for chemiluminescent substrates. Higher concentrations of antibody may be needed for samples from more distantly related species. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen. FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.
Immunogen Synthetic peptide based on the carboxy end of human ADAMTS1.
Species Reactivity Human
Specificity The antibody recognizes the zymogen of ADAMTS1, and the furin cleaved ADAMTS1, but not the shed form.
Tested Applications Western Blot 1:1000
Application Notes Recommended dilutions WB: Use at an assay dependent dilution. Predicted molecular weight: 105 kDa. A recommended starting concentration for Western blots is 1:1,000 when using colorimetric substrates such as BCIP/NBT, and 1:5,000 for chemiluminescent substrates. Higher concentrations of antibody may be needed for samples from more distantly related species. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Raised In Rabbit
Clonality Polyclonal
Isotype IgG
Purity Immunogen Affinity purified
Storage Buffer PBS, pH 7.4 with 0.05% sodium azide.
Formulation Liquid
Concentration 1ug/ul
Storage The undiluted antibody solution is stable for 12 months at -20°C.
Caution to ADAMTS-1 (A Disintigrin And Metalloproteinase with ThromboSpondin-1 motif, METH-1); Carboxyterminal end is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.

 

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