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Index / BPS Bioscience / Noggin / Product Detail : 90256-2 Noggin
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Nov
20th

#90256-2 Noggin

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  Price : 378   EUR
429   USD
293   GBP
1590   Zloty
50671   JPY
2920   NOK
3129   SEK
428   CHF

Product name : Noggin

Catalog number : 90256-2

Quantity: 50

Availability: Yes

Supplier name : BPS Bioscience

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More Details about

Description:  Human Noggin, also known
as  symphalangism  1  (SYM1)  or  synostoses
(multiple)  syndrome  1  (SYNS1),  GenBank
Accession No. NM_005450, amino-acids 28-
232(end),  disulfide-linked  homodimer.
MW=~28kDa (monomer), expressed in Freestyle 293F cells.
 
Endotoxin Level: <1 EU/μg.
 
Biological Activity:  measured  by
Noggin’s  ability  to  inhibit  BMP-4-induced
alkaline  phosphatase  production  by  C2C12
mouse  myoblast  cells.  The  ED50  is  <  20
ng/ml  in  the presence of 30 ng/ml of human
BMP-4.
 
Application:  Noggin gel

Useful  for  the  study  of  enzyme  kinetics,
screening  inhibitors,  and  selectivity
profiling. 

Formulation: Lyophilized  from  a  0.2  μM
filtered, aqueous solution.
 
Reconstitution: Supplied as a lyophilized solid.  
Reconstitute  in  sterile water with  0.1% BSA  to  a
final concentration of 0.1 mg/ml.  Final formulation
will be 50 mM Tris, pH 8.0, 1.2 M NaCl, 2.7 mM
KCl, 0.1% BSA.  
 
Stability:  ≥12  months  at  –80°C  (as  a  solid). 
Store  reconstituted  protein  in  aliquots  at  –20°C  to 
–80°C  for  up  to  6  months.  Avoid  freeze/thaw
cycles.
 
References:
1.  Tao, Y.X., et al. (2010). Indian J. Exp. Biol.
     48(5):444-52.
2.  Mfopou, J.K., et al. (2010). Gastroenter-ology.
     138(7):2233- 2245. 
3.  Chaturvedi, G., et al. (2009). Cell Prolif.
     42(4):425-33

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