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Index / QED / Anti_Thymidine Kinase Mono / Product Detail : 34003 Anti_Thymidine Kinase Mono
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#34003 Anti_Thymidine Kinase Mono

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  Price : 468   EUR
531   USD
363   GBP
1968   Zloty
62695   JPY
3613   NOK
3871   SEK
529   CHF

Product name : Anti_Thymidine Kinase Mono

Catalog number : 34003

Quantity: 200ug

Availability: Yes

Supplier name : QED

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More Details about

ORDERING INFORMATION

Catalog No.: 34003 (3B3.E11) Size: 200 ug Protein G-purified antibody in PBS: pH 7.4.

BACKGROUND

Thymidine kinase (TK) belongs to a group of enzymes such as dihydrofolate reductase, thymidylate synthase, and DNA polymerase that are involved in DNA synthesis and precursor production. High levels of these enzymes are present in proliferating cells, and low levels are found in resting cells, due to multiple regulatory mechanisms that ensure exclusive expression of these enzymes in replicating cells. TK is responsible for catalyzing the phosphorylation of thymidine, which functions as a part of the pyrimidine salvage pathway involved in DNA synthesis. The activities of enzymes such as TK are essential for the activation of several chemotherapeutically important nucleoside analogues that are administered as prodrugs.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.

SPECIFICATION SUMMARY

Antigen: 5'-His-tagged recombinant human thymidine kinase. Host Species: Mouse Antibody Class: lgG1 Stabilizers: None Preservatives: None. Available on request.

SPECIFICITY

This antibody specifically recognizes human thymidine kinase.

APPLICATIONS

Immunoblotting: antibody at 10 ug/ml will recognize TK in 5, 10, or 20 ug lysates of ceils that express TK. ELISA: use antibody at 2-5 ug/ml (optimized for TK on solid phase at 10 ug/ml).

DILUTION INSTRUCTIONS

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE AND STABILITY

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

 

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