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Index / Reliatech / Human PDGF_CC Source E. coli / Product Detail : 100-354 Human PDGF_CC Source E. coli
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Jul
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#100-354 Human PDGF_CC Source E. coli

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  Price : 323   EUR
366   USD
250   GBP
1357   Zloty
43228   JPY
2491   NOK
2669   SEK
365   CHF

Product name : Human PDGF_CC Source E. coli

Catalog number : 100-354

Quantity: 20 µg

Availability: Yes

Supplier name : Reliatech

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More Details about

Human PDGF-CC

Host:
E. coli
Size:
20 µg
Price:
 
Formulation:
lyophilized
Catalog Number:
100-354
Synonyms:
PDGF-CC
Purity Confirmation:
>98% (SDS-PAGE, HPLC)
Biological activity:
Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected The ED50 for this effect is 15-20 ng/ml.
Protein Sequence:
MVVDLNLLTE EVRLYSCTPR NFSVSIREEL KRTDTIFWPG CLLVKR CGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP KTGVRGLHKS L TDVALEHHE ECDCVCRGST GG
Description:
The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules epithelial cell development. Mature PDGFs are stored in platelet α-granules and are released upon platelet activation. PDGF-AA, -AB, -BB and –CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor. Recombinant human PDGF-CC is a 25 kDa protein consisting of two identical disulfide-linked 114 amino-acid polypeptide chains.
Uniprot:
Q9NRA1

 

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