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Index / Abfron / Thioredoxin Reductase 2, SelCys523Cys, Human / Product Detail : LF-P0019 Thioredoxin Reductase 2, SelCys523Cys, Human
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Sep
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#LF-P0019 Thioredoxin Reductase 2, SelCys523Cys, Human

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  Price : 375   EUR
426   USD
291   GBP
1577   Zloty
50242   JPY
2895   NOK
3102   SEK
424   CHF

Product name : Thioredoxin Reductase 2, SelCys523Cys, Human

Catalog number : LF-P0019

Quantity: 0.5 mg

Availability: Yes

Supplier name : Abfron

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About this Product :

Thioredoxin Reductase 2, SelCys523Cys, Human Human samples 80 % of the research is conducted on human samples. GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as Thioredoxin Reductase 2, SelCys523Cys, Human .
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The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxido-reductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly- Cys-) . However, they are distinct with a C-terminal extension containing a catalytically active enultimate selenocysteine (SeCys) residue in the conserved sequence(-Gly-Cys-SeCys- Gly). Each monomer in the homodimeric protein TrxR includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH and the active-site disulfide to C-terminal SeCys-containing redox center. Then this reduces substrates like thioredoxin. The members of TrxR family range from 55 to 58 kilodalton in molecular size and are composed of three isoforms. Such isoforms include cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, also known as Trx and GSSG reductase (TGR). TrxR plays a key role in protection of cells against oxidative stress and is part of the redox-regulatory mechanism of transcription factors and various biological phenomena.

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