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Index / Signosis 2011 / Stem Cell TF Activation Profiling Plate Array I / Product Detail : FA-1003 Stem Cell TF Activation Profiling Plate Array I
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#FA-1003 Stem Cell TF Activation Profiling Plate Array I

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  Price : 725   EUR
823   USD
562   GBP
3046   Zloty
97048   JPY
5593   NOK
5993   SEK
820   CHF

Product name : Stem Cell TF Activation Profiling Plate Array I

Catalog number : FA-1003

Quantity: 6

Availability: Yes

Supplier name : Signosis 2011

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Cancer Stem Cell TF Activation Profiling Plate Array

Transcriptional regulation plays a critical role in the control of biological processes, and transcription factors have been considered as master switches for cell fate determination. The cancer stem cell paradigm postulates that decontrolled tissue-specific stem cells or progenitor cells are precursors for cancer biogenesis. Cancer stem cells are a subset of cancer cells within a tumor that have stem cell-like characteristics. During tumorigenesis, deregulated transcription factor expression or activation can promote abnormal self-renewal, proliferation, and differentiation of the cells. For example, OCT4, Sox2,KLF4, Myc and Nanog have been shown to possess the power to reprogram somatic cells into pluripotent cells by reactivating pluripotent genes and silencing somatic genes. Understanding the activation patterns of cancer stem cell related transcription factors in a tumor can help to understand the transcriptional mechanism of cancer stem cell and provide better approaches for targeting and eliminating cancer stem cells.

List of Applicable TFs:

  1 2 3 4 5 6 7 8 9 10 11 12
A Androgen KLF4 Snail Androgen KLF4 Snail Androgen KLF4 Snail Androgen KLF4 Snail
B AP1 (Jun) Myc SOX2 AP1 (Jun) Myc SOX2 AP1 (Jun) Myc SOX2 AP1 (Jun) Myc SOX2
C AP2 Nanog SOX9 AP2 Nanog SOX9 AP2 Nanog SOX9 AP2 Nanog SOX9
D CREB NFkB1 STAT3 CREB NFkB1 STAT3 CREB NFkB1 STAT3 CREB NFkB1 STAT3
E ER NKX3.1 TBX3 ER NKX3.1 TBX3 ER NKX3.1 TBX3 ER NKX3.1 TBX3
F FoxO3 Oct-3/4 Twist-1 FoxO3 Oct-3/4 Twist-1 FoxO3 Oct-3/4 Twist-1 FoxO3 Oct-3/4 Twist-1
G GU p53 WT1 GU p53 WT1 GU p53 WT1 GU p53 WT1
H HIF-1 PRDM14 Blank HIF-1 PRDM14 Blank HIF-1 PRDM14 Blank HIF-1 PRDM14 Blank

 

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