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Index / Biovis / Tubastatin A / Product Detail : 1724-5 Tubastatin A
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Dec
3th

#1724-5 Tubastatin A

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  Price : 653   EUR
741   USD
507   GBP
2745   Zloty
87458   JPY
5040   NOK
5401   SEK
739   CHF

Product name : Tubastatin A

Catalog number : 1724-5

Quantity: 5 mg

Availability: Yes

Supplier name : Biovis

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More Details about

MOLECULAR WEIGHT: 371.86
CAS NUMBER: 1239262-52-5
APPEARANCE: Off-white solid
SOLUBILITY: DMSO (~90 mg/ml) or water (~ 4mg/ml) or 2% TWEEN-80/water (~2mg/ml) or 30% PEG (avg. MW = 400 g/mol)/50mM phosphate buffer (pH = 2.25) (25 mg/ml) (heating is required to initially dissolve the compound).
PURITY: 95% by HPLC
STORAGE: Store at -20℃
DESCRIPTION: Cell-permeable, A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16.4 μM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. Tubastatin A displayed dosedependent protection against HCA (homocysteic acid)- induced neuronal cell death starting at 5 μM with near complete protection at 10 μM.
HANDLING: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.


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