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Index / Biovis / Kenpaullone / Product Detail : 1904-1 Kenpaullone
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Apr
20th
#1904-1 Kenpaullone
Price : | 136 | EUR |
155 | USD | |
106 | GBP | |
575 | Zloty | |
18321 | JPY | |
1056 | NOK | |
1131 | SEK | |
154 | CHF |
Product name : Kenpaullone
Catalog number : 1904-1
Quantity: 1 mg
Availability: Yes
Supplier name : Biovis
Data sheet: Ask more or other datasheet now !
More Details about
Alternate Name/Synonyms: 9-Bromo-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
Peptide Sequence: N/A
Appearance: Tan solid
Formulation: N/A
CAS Number: 142273-20-9
Molecular Formula: C₁₆H₁₁BrN₂O
Molecular Weight: 327.18
Purity: ≥98%
Solubility: DMSO (>25 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Description: Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases. In addition, it has been found to be a useful GSK-3β inhibitor (IC₅₀ = 23nM). More recently, kenpaullone has been shown to increase neurogenesis of human neural progenitor cells through stimulation of Wnt/β-catenin signaling pathway
Handling: Protect from air and light
USAGE: For Research Use Only! Not For Use in Humans.
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Bibliography :
[29577900] Protective effects of kenpaullone on cardiomyocytes following HO-induced oxidative stress are attributed to inhibition of connexin 43 degradation by SGSM3.
[29515060] Isolation and characterization of buffalo (bubalus bubalis) amniotic mesenchymal stem cells derived from amnion from the first trimester pregnancy.
[29514916] CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss.
[29128602] Developmental effects of the protein kinase inhibitor kenpaullone on the sea urchin embryo.
[29046299] High-content screening assay-based discovery of paullones as novel podocyte-protective agents.
[28959019] CD24, CD44 and EpCAM enrich for tumour-initiating cells in a newly established patient-derived xenograft of nasopharyngeal carcinoma.
[28223128] A screening assay for the identification of host cell requirements and antiviral targets for hepatitis D virus infection.
[27008992] Small molecule-mediated up-regulation of microRNA targeting a key cell death modulator BNIP3 improves cardiac function following ischemic injury.
[26989171] Development of the aboral domain in Nematostella requires β-catenin and the opposing activities of Six3/6 and Frizzled5/8.
[26820057] Identification of compounds that modulate retinol signaling using a cell-based qHTS assay.
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