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Index / Trevigen / H2AX Phosphorylated Histone Double Affinity Purified Antibody / Product Detail : 4418-APC-100 H2AX Phosphorylated Histone Double Affinity Purified Antibody
#4418-APC-100 H2AX Phosphorylated Histone Double Affinity Purified Antibody
Product name : H2AX Phosphorylated Histone Double Affinity Purified Antibody
Catalog number : 4418-APC-100
Quantity: 100 ul
Supplier name : Trevigen
Data sheet: Ask more or other datasheet now !
About this Product :H2AX Phosphorylated Histone Double Affinity Purified Antibody antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of H2AX Phosphorylated Histone Double Affinity Purified Antibody.
More Details about
Background: Histone H2AX is a 14 kDa ubiquitous member of the H2A histone family that contains an evolutionarily conserved SQ motif at the C-terminus in eukaryotes. Serine 139 within this motif becomes rapidly phosphorylated to yield a form known as g-H2AX in response to double-strand DNA damage and apoptosis. Phosphorylation reaches half its maximum between 1-3 minutes after DNA damage occurs, and hundreds to several thousand molecules of g-H2AX are present per double-strand break. This antibody is unique in only detecting double-strand DNA breaks.
Physical State: Peptide affinity purified rabbit polyclonal antibody raised against synthetic phosphorylated peptide (CKATQA[pS]QEY). Provided at 0.5 μg/μl in phosphate buffered saline buffer with 50% glycerol.
Specificity: Recognizes human and mouse g-H2AX.
Applications: Suitable for Western blotting and immunocytochemistry (IC). For Western blot analysis, a starting dilution of 1:1,000 – 1:2,500 is recommended, whereas for IC, a starting dilution of 1:100 is recommended. Empirical determination of antibody concentration is required for optimal results.
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WP1807: Double-Strand Break Repair
WP2361: Gastric cancer network 1
WP2366: Butyrate-induced histone acetylation
WP2369: Histone modifications
WP300: Histone modifications
Related Genes :
[H2AFX H2AX] Histone H2AX (H2a/x) (Histone H2A.X)
[H2afx H2a.x H2ax Hist5-2ax] Histone H2AX (H2a/x) (Histone H2A.X)
[H2AX DDB_G0279667] Histone H2AX (H2a/x) (Histone H2A.X)
[HTA1 TTHERM_00790790] Histone H2AX (Histone H2A.1) (H2A1) (Histone H2A.X)
[HTA1] Histone H2AX (Histone H2A.1) (H2A1) (Histone H2A.X)
[h2afx zgc:56329] Histone H2AX (H2a/x) (Histone H2A.X)
[Eya1] Eyes absent homolog 1 (EC 126.96.36.199) (EC 188.8.131.52)
[ATM] Serine-protein kinase ATM (EC 184.108.40.206) (Ataxia telangiectasia mutated) (A-T mutated)
[PRKDC HYRC HYRC1] DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 220.127.116.11) (DNPK1) (p460)
[h2afx] Histone H2AX (H2a/x) (Histone H2A.X)
[BRCA1 RNF53] Breast cancer type 1 susceptibility protein (EC 18.104.22.168) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
[HSF1 HSTF1] Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1)
[EYA1] Eyes absent homolog 1 (EC 22.214.171.124) (EC 126.96.36.199)
[RNF8 KIAA0646] E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 188.8.131.52) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
[RNF168] E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 184.108.40.206) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168)
[APBB1 FE65 RIR] Amyloid beta A4 precursor protein-binding family B member 1 (Protein Fe65)
 Histone H2AX
[NBN NBS NBS1 P95] Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1)
[Atm] Serine-protein kinase ATM (EC 220.127.116.11) (Ataxia telangiectasia mutated homolog) (A-T mutated homolog)
[HIS2A] Histone H2AX
[ATR FRP1] Serine/threonine-protein kinase ATR (EC 18.104.22.168) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)
[OTUB1 OTB1 OTU1 HSPC263] Ubiquitin thioesterase OTUB1 (EC 22.214.171.124) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)
[EYA3] Eyes absent homolog 3 (EC 126.96.36.199)
[UIMC1 RAP80 RXRIP110] BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1)
[BRCC3 BRCC36 C6.1A CXorf53] Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)
[BAZ1B WBSC10 WBSCR10 WBSCR9 WSTF] Tyrosine-protein kinase BAZ1B (EC 188.8.131.52) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2)
[Rnf8] E3 ubiquitin-protein ligase RNF8 (EC 184.108.40.206) (ActA-interacting protein 37) (AIP37) (LaXp180) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
[MDC1 KIAA0170 NFBD1] Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
[Eya3] Eyes absent homolog 3 (EC 220.127.116.11)
[Apbb1 Fe65] Amyloid beta A4 precursor protein-binding family B member 1 (Protein Fe65)
 gamma-H2AX: Can it be established as a classical cancer prognostic factor?
 Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP.
 Alternative Chk1-independent S/M checkpoint in somatic cells that prevents premature mitotic entry.
 Double strand break repair and γ-H2AX formation in erythrocytes of medaka (Oryzias latipes) after γ-irradiation.
 The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D.
 Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer.
 Transmission of persistent ionizing radiation-induced foci through cell division in human primary cells.
 Repositioning disulfiram as a radiosensitizer against atypical teratoid/rhabdoid tumor.
 Combined therapy with melatonin and exendin-4 effectively attenuated the deterioration of renal function in rat cardiorenal syndrome.
 BRE modulates granulosa cell death to affect ovarian follicle development and atresia in the mouse.
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