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Index / Trevigen / Tankyrase 1 Colorimetric Activity Assay / Product Detail : 4700-192-K Tankyrase 1 Colorimetric Activity Assay
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#4700-192-K Tankyrase 1 Colorimetric Activity Assay

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  Price : 1494   EUR
1696   USD
1159   GBP
6278   Zloty
199966   JPY
11525   NOK
12349   SEK
1690   CHF

Product name : Tankyrase 1 Colorimetric Activity Assay

Catalog number : 4700-192-K

Quantity: 192 samples

Availability: Yes

Supplier name : Trevigen

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Tankyrase 1 Colorimetric Activity Assay
Catalog #: 4700-192-K

 Tankyrase 1 Colorimetric Activity Assay

Trevigen's Tankyrase 1 Colorimetric Activity Assay is a highly sensitive colorimetric screening kit for the identification of Tankyrase 1 inhibitors in an in vitro system. Tankyrase 1, also known as PARP5a, is a telomere associated poly (ADPribose) polymerase that is recruited to telomeres via its interaction with TRF1 and plays a role in the maintenance of telomere length, sister telomere association, and mitotic spindle organization1. Changes in telomere function have been associated
with various diseases, including cancer and aging. Tankyrase 1 has also been shown to destabilize axin, thereby activating Wnt signaling and driving tumor cell proliferation2,3. Given these known activities, Tankyrase 1 has become a prominent
cancer drug target4.

Trevigen's Tankyrase 1 Colorimetric Activity Assay is ideal for the screening of Tankyrase 1 inhibitors and determining IC50 values. The Tankyrase 1 Colorimetric Activity Assay is an ELISA which semi-quantitatively detects poly (ADP-ribose) (PAR) deposited onto immobilized histone proteins in a 96-well format. An anti-PAR monoclonal antibody, goat anti-mouse IgG-HRP conjugate, and HRP substrate are used to generate a colorimetric signal. Thus, the conversion of blue substrate correlates with Tankyrase 1 activity. Important features of the assay include: 1) colorimetric, non-radioactive format; 2) higher throughput 96 test size, and 3) sensitivity down to 0.1 mUnits of Tankyrase 1.

Precautions and Limitations

1. For Research Use Only. Not for use in diagnostic procedures.
2.The physical, chemical, and toxicological properties of the chemicals and reagents contained in the Tankyrase 1 Colorimetric Activity Assay may not yet have been fully investigated. Therefore, Trevigen recommends the use of gloves, lab coats, and eye protection while using any of these chemical reagents. Trevigen assumes no liability for damage resulting from

 

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