GENTAUR Molecular Products.
Monoclonal Antibody, ELISA Kit, Polyclonal Antibody, Recombinant/Purified Protein.
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Index / Biovis / Chk2 Inhibitor1 mg / Product Detail : 1702-1 Chk2 Inhibitor1 mg
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Oct
18th
#1702-1 Chk2 Inhibitor1 mg
| Price : | 177 | EUR |
| 201 | USD | |
| 137 | GBP | |
| 746 | Zloty | |
| 23761 | JPY | |
| 1369 | NOK | |
| 1467 | SEK | |
| 200 | CHF |
Product name : Chk2 Inhibitor1 mg
Catalog number : 1702-1
Quantity: 1 mg
Availability: Yes
Supplier name : Biovis
Data sheet: Ask more or other datasheet now !
More Details about
Alternate Name/Synonyms: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: 516480-79-8
Molecular Formula: C20H14CIN2O2
Molecular Weight: 363.8
Purity: ≥98% by HPLC
Solubility: DMSO (10 mg/ml)
Storage Temp.: +4°C
Shipping Conditions: RT
Description: A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC₅₀ = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC₅₀ = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC₅₀ of 3 µM and 7.6 µM, respectively.
Handling: Protect from air and moisture
USAGE: For Research Use Only! Not For Use in Humans.
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WP1013: Triacylglyceride Synthesis
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1050: Oxidative Stress
WP1124: metapathway biotransformation
WP1166: Oxidative Stress
WP1251: metapathway biotransformation
WP1286: metapathway biotransformation
WP1372: Oxidative Stress
WP1502: Mitochondrial biogenesis
WP173: Oxidative Stress
WP212: Triacylglyceride Synthesis
WP2141: serotonin and anxiety
WP2298: NFE2L2
WP2364: NFE2L2
WP2370: NFE2L2
WP2376: NFE2L2
WP279: Triacylglyceride Synthesis
WP310: mRNA processing
WP375: Wnt Signaling Pathway NetPath
WP408: Oxidative Stress
WP412: Oxidative Stress
WP65: Insulin Signaling
WP654: ATM
WP702: metapathway biotransformation
WP889: metapathway biotransformation
Related Genes :
[CHEK2 CDS1 CHK2 RAD53] Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)
[Chek2 Chk2 Rad53] Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Checkpoint kinase 2)
[chk-2 cds-1 Y60A3A.12] Serine/threonine-protein kinase chk-2 (EC 2.7.11.1) (Ce-cds-1) (Ce-chk-2)
[Chek2 rCG_21791] CHK2 checkpoint homolog (S. pombe), isoform CRA_a (Checkpoint kinase 2) (Checkpoint kinase Chk2)
[SIRT1 SIR2L1] NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
[CHEK1 CHK1] Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)
[PML MYL PP8675 RNF71 TRIM19] Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19)
[lok 10895 38B.4 chk CHK-2 CHK2 Chk2 chk2 DChk2 DmCHk2 DmChk2 Dmchk2 Dmel\CG10895 Dmnk Dmnk-L Dmnk-S LOKI MNK mnk CG10895 Dmel_CG10895] Loki, isoform C (EC 2.7.11.-) (EC 2.7.11.26)
[lok 10895 38B.4 chk CHK-2 CHK2 Chk2 chk2 DChk2 DmCHk2 DmChk2 Dmchk2 Dmel\CG10895 Dmnk Dmnk-L Dmnk-S lok-RC LOKI MNK mnk CG10895 Dmel_CG10895] Loki, isoform D (EC 2.7.11.-) (EC 2.7.11.26) (MIP15302p) (MIP15402p)
[ATM] Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
[BRCA1 RNF53] Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
[BRCA2 FACD FANCD1] Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein)
[ATMIN KIAA0431 ZNF822] ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ) (Zinc finger protein 822)
[COI] Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Fragment)
[YWHAZ] 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
[YWHAG] 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
[CHEK2] Checkpoint kinase 2 (Protein kinase CHK2 isoform a)
[CDK1 CDC2 CDC28A CDKN1 P34CDC2] Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
[YWHAB] 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
[Atmin Kiaa0431] ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ)
[YWHAE] 14-3-3 protein epsilon (14-3-3E)
[CDC28 CDK1 HSL5 SRM5 YBR160W YBR1211] Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (Cell division control protein 28) (Cell division protein kinase 1)
[CHEK2] Serine/threonine-protein kinase Chk2 isoform b
[I79_008128] Serine/threonine-protein kinase Chk2
[PSME3] Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma)
[E2F1 RBBP3] Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
[CHK2 GUITHDRAFT_88097] CHK2 DNA damage checkpoint kinase
[CHK2] Histidine kinase CHK2
[MDC1 KIAA0170 NFBD1] Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
[mei-41 CG4252] Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein homolog) (ATR homolog) (dATR) (Meiotic protein 41)
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