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Index / Biovis / Chk2 Inhibitor1 mg / Product Detail : 1702-1 Chk2 Inhibitor1 mg
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Dec
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#1702-1 Chk2 Inhibitor1 mg

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  Price : 177   EUR
201   USD
137   GBP
746   Zloty
23761   JPY
1369   NOK
1467   SEK
200   CHF

Product name : Chk2 Inhibitor1 mg

Catalog number : 1702-1

Quantity: 1 mg

Availability: Yes

Supplier name : Biovis

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More Details about

 

Alternate Name/Synonyms: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 516480-79-8

Molecular Formula: C20H14CIN2O2

Molecular Weight: 363.8

Purity: ≥98% by HPLC

Solubility: DMSO (10 mg/ml)

Storage Temp.: +4°C

Shipping Conditions: RT

Description: A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC₅₀ = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC₅₀ = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC₅₀ of 3 µM and 7.6 µM, respectively.

Handling: Protect from air and moisture

 

USAGE: For Research Use Only! Not For Use in Humans.

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