GENTAUR Molecular Products.
Monoclonal Antibody, ELISA Kit, Polyclonal Antibody, Recombinant/Purified Protein.
GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc 6017 Snell Ave, Ste 357, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, sales@genprice.com
Index / Biovis / Chk2 Inhibitor1 mg / Product Detail : 1702-1 Chk2 Inhibitor1 mg
Related keywords:
Sep
27th
#1702-1 Chk2 Inhibitor1 mg
| Price : | 177 | EUR |
| 201 | USD | |
| 137 | GBP | |
| 746 | Zloty | |
| 23761 | JPY | |
| 1369 | NOK | |
| 1467 | SEK | |
| 200 | CHF |
Product name : Chk2 Inhibitor1 mg
Catalog number : 1702-1
Quantity: 1 mg
Availability: Yes
Supplier name : Biovis
Data sheet: Ask more or other datasheet now !
More Details about
Alternate Name/Synonyms: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: 516480-79-8
Molecular Formula: C20H14CIN2O2
Molecular Weight: 363.8
Purity: ≥98% by HPLC
Solubility: DMSO (10 mg/ml)
Storage Temp.: +4°C
Shipping Conditions: RT
Description: A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC₅₀ = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC₅₀ = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC₅₀ of 3 µM and 7.6 µM, respectively.
Handling: Protect from air and moisture
USAGE: For Research Use Only! Not For Use in Humans.
Contact us about this product :
Our team will respond you as soon as possible !
We have also other products like : Chk2 Inhibitor1 mg
Related products : Chk2 Inhibitor1 mg
other names
GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45
Fax 0032 16 50 90 45
info@gentaur.com | Gentaur
GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur
GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50
Fax 01 43 25 01 60
RCS Paris B 484 237 888
SIRET 48423788800017
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
france@gentaur.com | Gentaur
GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur
GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel: 0208-080893 Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62 SWIFT RABONL2U
GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur
ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF
GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX 058 710 33 48
poland@gentaur.com | Gentaur
Other countries
Österreich +43720880899
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Danmark +4569918806
Finland Helsset +358942419041
Magyarország Budapest +3619980547
Ireland Dublin+35316526556
Luxembourg+35220880274
Norge Oslo+4721031366
Sverige Stockholm+46852503438
Schweiz Züri+41435006251
US New York+17185132983
GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo
Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur
Related products : Chk2 Inhibitor1 mg
Gentaurpub
WP1013: Triacylglyceride Synthesis
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1050: Oxidative Stress
WP1124: metapathway biotransformation
WP1166: Oxidative Stress
WP1251: metapathway biotransformation
WP1286: metapathway biotransformation
WP1372: Oxidative Stress
WP1502: Mitochondrial biogenesis
WP173: Oxidative Stress
WP212: Triacylglyceride Synthesis
WP2141: serotonin and anxiety
WP2298: NFE2L2
WP2364: NFE2L2
WP2370: NFE2L2
WP2376: NFE2L2
WP279: Triacylglyceride Synthesis
WP310: mRNA processing
WP375: Wnt Signaling Pathway NetPath
WP408: Oxidative Stress
WP412: Oxidative Stress
WP65: Insulin Signaling
WP654: ATM
WP702: metapathway biotransformation
WP889: metapathway biotransformation
Related Genes :
[CHEK2 CDS1 CHK2 RAD53] Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)
[Chek2 Chk2 Rad53] Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Checkpoint kinase 2)
[chk-2 cds-1 Y60A3A.12] Serine/threonine-protein kinase chk-2 (EC 2.7.11.1) (Ce-cds-1) (Ce-chk-2)
[Chek2 rCG_21791] CHK2 checkpoint homolog (S. pombe), isoform CRA_a (Checkpoint kinase Chk2) (Protein Chek2)
[BRCA1 RNF53] Breast cancer type 1 susceptibility protein (EC 6.3.2.-) (RING finger protein 53)
[SIRT1 SIR2L1] NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
[CHEK1 CHK1] Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)
[PML MYL PP8675 RNF71 TRIM19] Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19)
[ATMIN KIAA0431 ZNF822] ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ) (Zinc finger protein 822)
[ATM] Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
[BRCA2 FACD FANCD1] Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein)
[COI] Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Fragment)
[Atmin Kiaa0431] ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ)
[coi] Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Fragment)
[YWHAZ] 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
[CDK1 CDC2 CDC28A CDKN1 P34CDC2] Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
[CHEK2] Protein kinase CHK2 isoform a (Uncharacterized protein)
[CDC28 CDK1 HSL5 SRM5 YBR160W YBR1211] Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (Cell division control protein 28) (Cell division protein kinase 1)
[mei-41 CG4252] Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein homolog) (ATR homolog) (dATR) (Meiotic protein 41)
[MDC1 KIAA0170 NFBD1] Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
[E2F1 RBBP3] Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
[YWHAB] 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
[PSME3] Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma)
[YWHAE] 14-3-3 protein epsilon (14-3-3E)
[PLK3 CNK FNK PRK] Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase)
[CCAR2 DBC1 KIAA1967] Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC)
[RAD51C RAD51L2] DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2)
[CCNB1 CCNB] G2/mitotic-specific cyclin-B1
[SFN HME1] 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
[chk-2 Cbr-chk-2 CBG20512 CBG_20512] Protein CBR-CHK-2
Bibliography :
[27654901] HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization.
[27643582] Comparison of the Radiosensitizing Effect of ATR, ATM and DNA-PK Kinase Inhibitors on Cervical Carcinoma Cells.
[27621574] Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer.
[27609583] [Preparation and identification of monoclonal antibodies against chicken cell cycle checkpoint kinase 2 (cChk2)].
[27601420] Exposure to cyclic volatile methylsiloxanes (cVMS) causes anchorage-independent growth and reduction of BRCA1 in non-transformed human breast epithelial cells.
[27600610] Effect of Combined Treatment of Radiation and Tissue-specific Recombinant Oncolytic Adenovirus on bladder cancer cells.
[27599846] DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP.
[27597417] Stabilization of c-myc G-Quadruplex DNA, inhibition of telomerase activity, disruption of mitochondrial functions and tumor cell apoptosis by platinum(II) complex with 9-amino-oxoisoaporphine.
[27574017] The novel mTORC1/2 dual inhibitor INK128 enhances radiosensitivity of breast cancer cell line MCF-7.
[27564101] Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia.
Share this page:
Enter catalog number :
Favorites Pages:
No Favorits