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Index / BPS Bioscience / PDE1B Assay Kit / Product Detail : 60311 PDE1B Assay Kit
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Apr
21th
#60311 PDE1B Assay Kit
Price : | 615 | EUR |
698 | USD | |
477 | GBP | |
2584 | Zloty | |
82305 | JPY | |
4743 | NOK | |
5083 | SEK | |
695 | CHF |
Product name : PDE1B Assay Kit
Catalog number : 60311
Quantity: 100 reactions
Availability: Yes
Supplier name : BPS Bioscience
Data sheet: Ask more or other datasheet now !
More Details about
DESCRIPTION: Phosphodiesterases (PDEs) play an important role in dynamic
regulation of cAMP and cGMP signaling. PDE1B is a calcium-dependent cyclic
nucleotide phosphodiesterase that is highly expressed in the striatum. It plays a
physiological role in the central nervous system, and PDE1B activity has been linked to
impaired cognition and spatial learning. The PDE1B Assay Kit is designed for
identification of PDE1B inhibitors using fluorescence polarization. The assay is based on
the binding of a fluorescent nucleotide monophosphate generated by PDE1B to the
binding agent.
Phosphodiesterases catalyze the hydrolysis of the phosphodiester bond in dye-labeled
cyclic monophosphates. Beads selectively bind the phosphate group in the nucleotide
product. This increases the size of the nucleotide relative to unreacted cyclic
monophosphate. In the polarization assay, dye molecules with absorption transition
vectors parallel to the linearly-polarized excitation light are selectively excited. Dyes
attached to the rapidly-rotating cyclic monophosphates will obtain random orientations
and emit light with low polarization. Dyes attached to the slowly-rotating nucleotide-bead
complexes will not have time to reorient and therefore will emit highly polarized light.
The PDE1B inhibitor screening assay kit comes in a convenient 96-well format,
including purified PDE1B enzyme, fluorescently labeled PDE1B substrate (cAMP),
binding agent, and PDE assay buffer for 100 enzyme reactions. The key to the PDE1B
Assay Kit is the specific binding agent. Using this kit, only two simple steps on a
microtiter plate are required for PDE1B reactions. First, the fluorescently labeled cAMP
is incubated with a sample containing PDE1B for 1 hour. Second, a binding agent is
added to the reaction mix to produce a change in fluorescent polarization that can then be
measured using a fluorescence reader equipped for the measurement of fluorescence
polarization.
COMPONENTS:
APPLICATIONS: Great for studying enzyme kinetics and screening small molecular
inhibitors for drug discovery and HTS applications.
REFERENCE:
Siuciak JA, et al. (2007) Neuropharmacology 53(1):113-24.
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Related Genes :
[PDE1B PDE1B1 PDES1B] Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)
[Pde1b Pde1b1] Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)
[Pde1b Pde1b1] Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)
[PDE1B PDE1B1] Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)
[PDE1B1] Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (Fragment)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B CK820_G0046524] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[POT1] Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B PANDA_012629] Phosphodiesterase (EC 3.1.4.-) (Fragment)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B GW7_04406] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B hCG_21934] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[PDE1B] Phosphodiesterase (EC 3.1.4.-)
[Pde1b] Phosphodiesterase (EC 3.1.4.-)
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