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Product name : Anti-Chymotrypsin
Catalog number : 13603
Supplier name : QED
Data sheet: Ask more or other datasheet now !
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This red cAMP derivative is a specific substrate for phosphodiesterase (PDE) IV. It can be used for assaying PDE IV activities or screening PDE IV inhibitors in combination with anti-cAMP antibody in a FRET readout or FP format. PDE is a group of enzymes that degrade the second messenger molecules: cyclic nucleotides cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules. PDE enzymes are often targets for pharmacological inhibition due to their unique tissue distribution, structural and functional properties. Inhibitors of PDE can prolong or enhance the effects of physiological processes mediated by cAMP or cGMP by inhibition of their degradation by PDE. PDE inhibitors have been identified as new potential therapeutics in areas such as pulmonary arterial hypertension, coronary heart disease, dementia, depression and schizophrenia.
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WP1963: The effect of Glucocorticoids on target gene expression
Related Genes :
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 184.108.40.206) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[F9] Coagulation factor IX (EC 220.127.116.11) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]
[TP53 P53] Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
[CTRC CLCR] Chymotrypsin-C (EC 18.104.22.168) (Caldecrin)
[rseA mclA yfiJ b2572 JW2556] Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA) (Sigma-E factor negative regulatory protein)
[BCL2] Apoptosis regulator Bcl-2
[rsrA SCO5217] Anti-sigma factor RsrA (Regulator of SigR) (Sigma-R anti-sigma factor RsrA)
[BCAR1 CAS CASS1 CRKAS] Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
[Ctrb1 Ctrb] Chymotrypsinogen B (EC 22.214.171.124) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C]
[Bcl2 Bcl-2] Apoptosis regulator Bcl-2
[AMHR2 AMHR MISR2] Anti-Muellerian hormone type-2 receptor (EC 126.96.36.199) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII)
[ASF1 CIA1 YJL115W J0755] Histone chaperone ASF1 (Anti-silencing function protein 1) (yASF1)
[APP A4 AD1] Amyloid beta A4 protein (ABPP) (APPI) (APP) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Beta-amyloid precursor protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
[CELA1 ELA1] Chymotrypsin-like elastase family member 1 (EC 188.8.131.52) (Elastase-1)
[OTUD7B ZA20D1] OTU domain-containing protein 7B (EC 184.108.40.206) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)
[chrR RHOS4_27110 RSP_1093] Anti-sigma-E factor ChrR (Sigma-E anti-sigma factor ChrR) (Transcriptional activator ChrR)
[Cela1 Ela1] Chymotrypsin-like elastase family member 1 (EC 220.127.116.11) (Elastase-1)
[CTRB1 CTRB] Chymotrypsinogen B (EC 18.104.22.168) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C]
 Cytochrome c oxidase subunit 1 (EC 22.214.171.124) (Fragment)
[SLPI WAP4 WFDC4] Antileukoproteinase (ALP) (BLPI) (HUSI-1) (Mucus proteinase inhibitor) (MPI) (Protease inhibitor WAP4) (Secretory leukocyte protease inhibitor) (Seminal proteinase inhibitor) (WAP four-disulfide core domain protein 4)
 Chymotrypsin-like protease VLCTLP (EC 3.4.21.-) (Snake venom serine protease) (SVSP) (Vipera Lebetina with chymotrypsin-like proteolytic activity)
[CTRB2] Chymotrypsinogen B2 (EC 126.96.36.199) [Cleaved into: Chymotrypsin B2 chain A; Chymotrypsin B2 chain B; Chymotrypsin B2 chain C]
[CELA1 ELA1] Chymotrypsin-like elastase family member 1 (EC 188.8.131.52) (Elastase-1) (Pancreatic elastase 1)
[BTG2 PC3] Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3)
 Chymotrypsinogen A (EC 184.108.40.206) [Cleaved into: Chymotrypsin A chain A; Chymotrypsin A chain B; Chymotrypsin A chain C]
[Amhr2] Anti-Muellerian hormone type-2 receptor (EC 220.127.116.11) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII)
[Amhr2] Anti-Muellerian hormone type-2 receptor (EC 18.104.22.168) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (C14) (MIS type II receptor) (MISRII) (MRII)
[rslA Rv0736] Anti-sigma-L factor RslA (Regulator of SigL) (Sigma-L anti-sigma factor RslA)
[ASF1A CGI-98 HSPC146] Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA)
[CELA2A ELA2A] Chymotrypsin-like elastase family member 2A (EC 22.214.171.124) (Elastase-2A)
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