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Product name : Anti-Chymotrypsin
Catalog number : 13604
Supplier name : QED
Data sheet: Ask more or other datasheet now !
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This green fluorescent cGMP derivative is a specific substrate for phosphodiesterase (PDE) V. It can be used for assaying PDE V activities or screening PDE V inhibitors in combination with anti-cGMP antibody in a FRET readout or FP format. PDE is a group of enzymes that degrade the second messenger molecules: cyclic nucleotides cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules. PDE enzymes are often targets for pharmacological inhibition due to their unique tissue distribution, structural and functional properties. Inhibitors of PDE can prolong or enhance the effects of physiological processes mediated by cAMP or cGMP by inhibition of their degradation by PDE. PDE inhibitors have been identified as new potential therapeutics in areas such as pulmonary arterial hypertension, coronary heart disease, dementia, depression and schizophrenia. For example, Sildenafil (Viagra) is an inhibitor of cGMP-specific PDE V, which enhances the vasodilatory effects of cGMP in the corpus cavernosum, and is used to treat erectile dysfunction.
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WP1963: The effect of Glucocorticoids on target gene expression
Related Genes :
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 22.214.171.124) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[F9] Coagulation factor IX (EC 126.96.36.199) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]
[TP53 P53] Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
[CTRC CLCR] Chymotrypsin-C (EC 188.8.131.52) (Caldecrin)
[BCL2] Apoptosis regulator Bcl-2
[rseA mclA yfiJ b2572 JW2556] Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA) (Sigma-E factor negative regulatory protein)
[rsrA SCO5217] Anti-sigma factor RsrA (Regulator of SigR) (Sigma-R anti-sigma factor RsrA)
[BCAR1 CAS CASS1 CRKAS] Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
[Bcl2 Bcl-2] Apoptosis regulator Bcl-2
[AMHR2 AMHR MISR2] Anti-Muellerian hormone type-2 receptor (EC 184.108.40.206) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII)
[Ctrb1 Ctrb] Chymotrypsinogen B (EC 220.127.116.11) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C]
[ASF1 CIA1 YJL115W J0755] Histone chaperone ASF1 (Anti-silencing function protein 1) (yASF1)
[chrR RHOS4_27110 RSP_1093] Anti-sigma-E factor ChrR (Sigma-E anti-sigma factor ChrR) (Transcriptional activator ChrR)
[CELA1 ELA1] Chymotrypsin-like elastase family member 1 (EC 18.104.22.168) (Elastase-1)
 Cytochrome c oxidase subunit 1 (EC 22.214.171.124) (Fragment)
[BTG2 PC3] Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3)
[Cela1 Ela1] Chymotrypsin-like elastase family member 1 (EC 126.96.36.199) (Elastase-1)
[APP A4 AD1] Amyloid beta A4 protein (ABPP) (APPI) (APP) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Beta-amyloid precursor protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
 Chymotrypsin-like protease VLCTLP (EC 3.4.21.-) (Snake venom serine protease) (SVSP) (Vipera Lebetina with chymotrypsin-like proteolytic activity)
[CTRB1 CTRB] Chymotrypsinogen B (EC 188.8.131.52) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C]
[SLPI WAP4 WFDC4] Antileukoproteinase (ALP) (BLPI) (HUSI-1) (Mucus proteinase inhibitor) (MPI) (Protease inhibitor WAP4) (Secretory leukocyte protease inhibitor) (Seminal proteinase inhibitor) (WAP four-disulfide core domain protein 4)
[CTRB2] Chymotrypsinogen B2 (EC 184.108.40.206) [Cleaved into: Chymotrypsin B2 chain A; Chymotrypsin B2 chain B; Chymotrypsin B2 chain C]
[CELA1 ELA1] Chymotrypsin-like elastase family member 1 (EC 220.127.116.11) (Elastase-1) (Pancreatic elastase 1)
[Amhr2] Anti-Muellerian hormone type-2 receptor (EC 18.104.22.168) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII)
[OTUD7B ZA20D1] OTU domain-containing protein 7B (EC 22.214.171.124) (Cellular zinc finger anti-NF-kappa-B protein) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)
[Amhr2] Anti-Muellerian hormone type-2 receptor (EC 126.96.36.199) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (C14) (MIS type II receptor) (MISRII) (MRII)
[rslA Rv0736] Anti-sigma-L factor RslA (Regulator of SigL) (Sigma-L anti-sigma factor RslA)
 Chymotrypsinogen A (EC 188.8.131.52) [Cleaved into: Chymotrypsin A chain A; Chymotrypsin A chain B; Chymotrypsin A chain C]
[rsbW usfX Rv3287c] Anti-sigma-F factor RsbW (Anti-sigma-F factor UsfX) (Regulator of SigF) (Sigma-F anti-sigma factor RsbW)
[AMH MIF] Muellerian-inhibiting factor (Anti-Muellerian hormone) (AMH) (Muellerian-inhibiting substance) (MIS)
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