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#34003 Anti-Thymidine Kinase
Product name : Anti-Thymidine Kinase
Catalog number : 34003
Supplier name : QED
Data sheet: Ask more or other datasheet now !
More Details about
Catalog No.: 34003 (3B3.E11) Size: 200 ug Protein G-purified antibody in PBS: pH 7.4.
Thymidine kinase (TK) belongs to a group of enzymes such as dihydrofolate reductase, thymidylate synthase, and DNA polymerase that are involved in DNA synthesis and precursor production. High levels of these enzymes are present in proliferating cells, and low levels are found in resting cells, due to multiple regulatory mechanisms that ensure exclusive expression of these enzymes in replicating cells. TK is responsible for catalyzing the phosphorylation of thymidine, which functions as a part of the pyrimidine salvage pathway involved in DNA synthesis. The activities of enzymes such as TK are essential for the activation of several chemotherapeutically important nucleoside analogues that are administered as prodrugs.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.
Antigen: 5'-His-tagged recombinant human thymidine kinase. Host Species: Mouse Antibody Class: lgG1 Stabilizers: None Preservatives: None. Available on request.
This antibody specifically recognizes human thymidine kinase.
Immunoblotting: antibody at 10 ug/ml will recognize TK in 5, 10, or 20 ug lysates of ceils that express TK. ELISA: use antibody at 2-5 ug/ml (optimized for TK on solid phase at 10 ug/ml).
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
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WP1493: Carbon assimilation C4 pathway
WP1567: Glycolysis and Gluconeogenesis
WP1619: Amino sugar and nucleotide sugar metabolism
WP1653: Galactose metabolism
WP1681: Pantothenate and CoA biosynthesis
WP1701: Starch and sucrose metabolism
WP1703: Streptomycin biosynthesis
WP1844: MAP kinase cascade
WP1845: MAPK targets/ Nuclear events mediated by MAP kinases
WP1946: Cori Cycle
WP1963: The effect of Glucocorticoids on target gene expression
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP32: Translation Factors
Related Genes :
[TK2] Thymidine kinase 2, mitochondrial (EC 184.108.40.206) (Mt-TK)
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 220.127.116.11) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[TP53 P53] Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
[TK1] Thymidine kinase, cytosolic (EC 18.104.22.168)
[Tk2] Thymidine kinase 2, mitochondrial (EC 22.214.171.124) (Mt-TK)
[BCL2] Apoptosis regulator Bcl-2
[TYMP ECGF1] Thymidine phosphorylase (TP) (EC 126.96.36.199) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase)
[rseA mclA yfiJ b2572 JW2556] Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA) (Sigma-E factor negative regulatory protein)
[rsrA SCO5217] Anti-sigma factor RsrA (Regulator of SigR) (Sigma-R anti-sigma factor RsrA)
[BCAR1 CAS CASS1 CRKAS] Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
[Bcl2 Bcl-2] Apoptosis regulator Bcl-2
[tmk Rv3247c] Thymidylate kinase (EC 188.8.131.52) (Thymidine monophosphate kinase) (dTMP kinase) (TMPK)
[TK UL23] Thymidine kinase (EC 184.108.40.206)
[AMHR2 AMHR MISR2] Anti-Muellerian hormone type-2 receptor (EC 220.127.116.11) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII)
[TK1A At3g07800 F17A17.14 MLP3.25] Thymidine kinase a (AtTK1a) (EC 18.104.22.168)
[ASF1 CIA1 YJL115W J0755] Histone chaperone ASF1 (Anti-silencing function protein 1) (yASF1)
[chrR RHOS4_27110 RSP_1093] Anti-sigma-E factor ChrR (Sigma-E anti-sigma factor ChrR) (Transcriptional activator ChrR)
[JBP1] Thymine dioxygenase JBP1 (EC 22.214.171.124) (J-binding protein 1) (Thymidine hydroxylase JBP1)
[TK1B At5g23070 MYJ24.6] Thymidine kinase b (AtTK1b) (EC 126.96.36.199)
[Tk1 Tk-1] Thymidine kinase, cytosolic (EC 188.8.131.52)
 Cytochrome c oxidase subunit 1 (EC 184.108.40.206) (Fragment)
[BTG2 PC3] Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3)
[tdk TM_0401] Thymidine kinase (EC 220.127.116.11)
[TK MVA086R ACAM3000_MVA_086 J2R] Thymidine kinase (EC 18.104.22.168)
[Tk1 Tk-1] Thymidine kinase, cytosolic (EC 22.214.171.124) (Fragment)
[Amhr2] Anti-Muellerian hormone type-2 receptor (EC 126.96.36.199) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII)
[thymidine kinase/TK] Thymidine kinase (EC 188.8.131.52)
[thyB DDB_G0289179] Thymidine kinase 1 (TK1) (EC 184.108.40.206) (Calmodulin-binding protein ThyB)
[thymidine kinase] Thymidine kinase (EC 220.127.116.11)
[TK2 QccE-13136] Thymidine kinase 2, mitochondrial (EC 18.104.22.168) (Mt-TK)
 Synthesis, anti-thymidine phosphorylase activity and molecular docking of 5-thioxo-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ones.
 A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities.
 The development and validation of an immunoassay for the measurement of anti-thymidine phosphorylase antibodies in mouse and dog sera.
 Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors.
 Development of human anti-thymidine kinase antibodies.
 [Successful treatment of hepatic metastasis of gastric cancer with 5'-DFUR and Lentinan].
 Detection of single-stranded DNA damage using monoclonal anti-thymidine antibody.
 [Approaches to predicting the reaction of human tumors to radiotherapy].
 Local and overall conformations of DNA double helices with the A - T base pairs.
 Binding of cis- and trans-diamminedichloroplatinum(II) to deoxyribonucleic acid exposes nucleosides as measured immunochemically with anti-nucleoside antibodies.
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