GENTAUR Molecular Products.
Monoclonal Antibody, ELISA Kit, Polyclonal Antibody, Recombinant/Purified Protein.
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Index / Biovis / PD-0325901; Appearance Off-white solid / Product Detail : 1643-25 PD-0325901; Appearance Off-white solid
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#1643-25 PD-0325901; Appearance Off-white solid
| Price : | 1280 | EUR |
| 1453 | USD | |
| 993 | GBP | |
| 5379 | Zloty | |
| 171338 | JPY | |
| 9875 | NOK | |
| 10581 | SEK | |
| 1448 | CHF |
Product name : PD-0325901; Appearance Off-white solid
Catalog number : 1643-25
Quantity: 25 mg
Availability: Yes
Supplier name : Biovis
Data sheet: Ask more or other datasheet now !
More Details about
MOLECULAR WEIGHT: 482.2
CAS NUMBER: 391210-10-9
APPEARANCE: Off-white solid
Solubility: DMSO or Ethanol (~20 mg/ml)
PURITY: >98% by HPLC
STORAGE: Keep cool and dry. Store at -20°C
DESCRIPTION: A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.
HANDLING: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
FOR RESEARCH USE ONLY! Not to be used on humans.
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Bibliography :
[29642934] Correlation of gene expression and associated mutation profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with chemosensitivity of cancer cell lines to drug treatment.
[29397960] Synergistic anti-proliferative effects of mTOR and MEK inhibitors in high-grade chondrosarcoma cell line OUMS-27.
[29179218] Puerarin Enhances Ca2+ Reuptake and Ca2+ Content of Sarcoplasmic Reticulum in Murine Embryonic Stem Cell-Derived Cardiomyocytes via Upregulation of SERCA2a.
[29067643] A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer.
[28923853] Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase-Driven Leukemias and Other Malignancies.
[28865806] Resveratrol promotes human embryonic stem cells self-renewal by targeting SIRT1-ERK signaling pathway.
[28856457] Mitogen-activated protein kinases (MAPKs) are modulated during in vitro and in vivo infection with the intracellular bacterium Burkholderia pseudomallei.
[28691888] Signal-Regulated Protein Kinases/Protein Kinase B-p53-BH3-Interacting Domain Death Agonist Pathway Regulates Gingipain-Induced Apoptosis in Osteoblasts.
[28644741] Ras Signaling Regulates Stem Cells and Amelogenesis in the Mouse Incisor.
[28606806] BCL2 induced by LAMTOR3/MAPK is a druggable target of chemoradioresistance in mesenchymal lung cancer.
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