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Index / Gentaur / Cholera toxin azide free / Product Detail : 19-CHOL Cholera toxin azide free
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Jul
28th

#19-CHOL Cholera toxin azide free

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  Price : 353   EUR
400   USD
273   GBP
1483   Zloty
47236   JPY
2722   NOK
2917   SEK
399   CHF

Product name : Cholera toxin azide free

Catalog number : 19-CHOL

Quantity: 1 mg

Availability: Yes

Supplier name : Gentaur

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More Details about

CHOLERA TOXINS AND RELATED PRODUCTS 
Produced by Vibrio cholerae, cholera toxin (CT) is a multimeric enterotoxin that transfers ADP-ribose to a G protein, locking adenyl cyclase in an 'on' position. By binding to the membrane of enteric cells, cholera toxin stimulates the cellular adenylate cyclase system, causing the hyper-secretion of chloride and bicarbonate ions, which results in increased fluid secretion and the severe diarrhea characteristic of the disease cholera. The pentameric B subunit of CT binds with high efficiency to GM1 monosialoganglioside cell membrane receptors, present in many cell types, allowing its use experimentally in cell culture.  Following binding, the toxin is endocytosed and travels retrogradely to the endoplasmic reticulum where the enzymatically active A subunit (CTA1) is translocated to the cytosol.  Within the cytosol, CTA1 catalyzes the ADP-ribosylation of the Gs protein, activating adenylate cyclase and as a consequence increasing the intracellular concentration of cAMP.  Relevant to the development of vaccine adjuvants, CT effectively modulates mammalian immune systems and acts as an adjuvant for co-administered antigens. 

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