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Index / BBridge / RANK Ligand Soluble, Human, recombinant / Product Detail : 188-01473 RANK Ligand Soluble, Human, recombinant
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Sep
30th

#188-01473 RANK Ligand Soluble, Human, recombinant

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Product name : RANK Ligand Soluble, Human, recombinant

Catalog number : 188-01473

Quantity: 1 mg

Availability: Yes

Supplier name : BBridge

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About this Product :

RANK Ligand Soluble, Human, recombinant recombinant proteins Most stable storage is at - 81 C or lower but some lyophilised proteins can be stored at +4C. Please read carefully the data sheet of the RANK Ligand Soluble, Human, recombinant.
http://mybiofast.com/ver.php?search=rec.&submit=Search

RANK Ligand Soluble, Human, recombinant Human samples 80 % of the research is conducted on human samples. GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as RANK Ligand Soluble, Human, recombinant.
http://mybiofast.com/ver.php?search=human+&submit=Search

More Details about

Source : Human RANK ligand cDNA expressed in E. coli
Appearance : Lyophilized powder (carrier free)
Molecular weight : 20,000
Biological Activity : The ED50 is less than 10ng/mL determined by the dose-dependent stimulation of IL-8 production by human PBMC cells.
Endotoxin : Less than 0.1 ng/ g (1 EU/ g)
Reconstitution : Reconstitute in water to a concentration of 0.1 1.0 mg/mL. Avoid multiple freeze-thaw cycles.
Storage Store at 20
Package
182-01471: 10 µg
186-01474: 50 µg
188-01473: 1 mg

 

Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene.[1][2] RANKL is important in bone metabolism. This natural and necessary surface-bound molecule (also known as CD254) found on osteoblasts serves to activate osteoclasts, which are the cells involved in bone resorption. [edit] Function RANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL also has a function in the immune system, where it is expressed by T helper cells and is thought to be involved in dendritic cell maturation. This protein was shown to be a dendritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor 6 (TRAF6), which indicated this protein may have a role in the regulation of cell apoptosis.

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