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Index / Neuromi / pro-insulin recombinant protein, 50 ug. / Product Detail : PR15081-50 pro-insulin recombinant protein, 50 ug.
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Dec
4th

#PR15081-50 pro-insulin recombinant protein, 50 ug.

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  Price : 436   EUR
495   USD
338   GBP
1833   Zloty
58401   JPY
3366   NOK
3606   SEK
493   CHF

Product name : pro-insulin recombinant protein, 50 ug.

Catalog number : PR15081-50

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Availability: Yes

Supplier name : Neuromi

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About this Product :

pro-insulin recombinant protein, 50 ug. recombinant proteins Most stable storage is at - 81 C or lower but some lyophilised proteins can be stored at +4C. Please read carefully the data sheet of the pro-insulin recombinant protein, 50 ug..
http://mybiofast.com/ver.php?search=rec.&submit=Search

More Details about

Type: Protein
Size: 50 ug
 
Species Reactivity: H; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
 
Description/Data:
pro-Insulin is synthesized as a single chain, 110 amino acid (aa) preproprecursor that contains a 24 aa signal sequence and an 86 aa proinsulin propeptide. Following removal of the signal peptide, the pro-insulin peptide undergoes further proteolysis to generate mature insulin, a 51 aa disulfide linked dimer that consists of a 30 aa B chain (aa 25 54) bound to a 21 aa A chain (aa 90 110). The 34 aa intervening peptide (aa 55 89) that connects the B and A chains is termed the C-peptide. Human proIinsulin shares 84% and 80% aa sequence identity with the rat and bovine protein, respectively. Most of the sequence variation between species occurs in the region of the C-peptide (1).

This peptide generates a structural conformation that allows for the correct formation of the intrachain disulphide bonds (1). Insulin is a molecule that facilitates the cellular uptake of glucose. This is accomplished by regulating the appearance of membrane glucose transporters. Low insulin levels or lack of insulin are associated with type 2 and type 1 diabetes mellitus, respectively. These conditions are associated with an increased risk for microvascular complications such as retinopathy, nephropathy, and peripheral neuropathy (3). pro-Insulin also circulates, but its physiologic role is less well understood. It does possess about 25% of the activity of mature insulin, but it would seem unlikely to be a natural substitute for insulin (4). In type 2 diabetes, an elevated pro-insulin to insulin ratio in the circulation is a wellknown abnormality (5 9). Perhaps this abnormality represents either compromised proteolytic processing or a general inability to process increased levels of insulin precursor (5). In any event, pro-insulin will stimulate amylin secretion by β-cells, and amyloid formation in pancreatic islets that promotes decreased β cell function (10). Studies also suggest that fasting serum proinsulin may be a better predictor of future type 2 diabetes than fasting insulin levels in obese children (11).

 

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