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Index / JaIC / Anti 8_OHdG monoclonal antibody / Product Detail : MOG-020P Anti 8_OHdG monoclonal antibody
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Aug
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#MOG-020P Anti 8_OHdG monoclonal antibody

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  Price : 287   EUR
326   USD
223   GBP
1208   Zloty
38504   JPY
2219   NOK
2377   SEK
325   CHF

Product name : Anti 8_OHdG monoclonal antibody

Catalog number : MOG-020P

Quantity: 20 micro gram

Availability: Yes

Supplier name : JaIC

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About this Product :

Anti 8_OHdG monoclonal antibody http://biotech-map.com/aa_search/table_sample.html?q=monoclonal&filter=
Description
Anti 8_OHdG monoclonal antibody is a monoclonal antibody which is greatly purified and with high binding affinity for the antigen that it is risen against. If used correctly and according the protocol, this antibody will provide excellent and reproducible results with guaranteed success for the tested and confirmed applications. Amongst the advantages of the monoclonal antibodies are: the fact that while the hybridoma takes a bit longer to be produced, once the line is ready there is virtually an endless supply of these antibodie throughout time with little to no variations in recognition sites of the antigen in different batches; in comparison to the polyclonal antibodies monoclonal antibodies are highly specific to a given epitope and can be used in applications where specific targeting is required.

More Details about

 

Anti 8-OHdG/ 8-oxo-dG/ 8-hydroxy-2'-deoxyguanosine monoclonal antibody (N45.1).
Suitable for immunohistocheistry and ELISA. For research use only.
About 8-hydroxy-2'-deoxyguanosine (8-OHdG):
Reactive oxygen species (ROS) and oxidative stress may be crucial for development of various diseases such as diabetes, cancer, and may play an important role in the aging process. 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a product of oxidatively damaged DNA formed by hydroxy radical, singlet oxygen and direct photodynamic action. 8-OHdG can be detected in tissue, serum, urine and other biomaterials. Anti 8-OHdG monoclonal antibody (clone N45.1) is highly specific for DNA damage, not cross react with RNA oxidation products such as 8-hydroxy-guanine and 8-hydroxy-guanosine. Suitable for immunohistochemistry and ELISA.
Epidermis from hairless mouse by chronic UVB irradiation after 4 weeks of treatment stained with N45.1.
(Y.Hattori, et.al.: J Invest Dermatol 107, p733-737, 1996)
Specifications
Clone #: N45.1
Antigen: 8-OHdG-conjugated Keyhole Limpet Hemocyanin
Subclass: Mouse IgG1(kappa)
Prepared as ascite, and ammnonium sulphate purified.
Form: Lyophilized Powder
Package: 20 or 100 micro gram of IgG / vial (MOG-020P and MOG-100P respectively).
Specificity: 19 analogues of 8-OHdG {guanosine (G), 7-methyl-G, 6-SH-G, 8-bromo-G, dA, dC, dT, dI, dU, dG, O6-methyl-dG, 8-OHdA, guanine (Gua), O6-methyl-Gua, 8-OHGua, uric acid, Urea, creatine, creatinine} demonstrate no cross-reactivity. Only 8-sulfhydryl-G and 8-OHG demonstrate minimal cross-reactivity (less than 1%).
Use: Immunohistochemistry and ELISA
Storage: Less than -20°C for 5 years
When transport, stable at least 7 days at room temperature.
References
1) S.Toyokuni, T.Tanaka, Y.Hattori, Y,Nishiyama, A.Yoshida, K.Uchida, H.Hiai, H.Ochi, and T.Osawa: Quantitative immunohistochemical determination of 8-hydroxy-2'deoxyguanosine by a monoclonal antibody N45.1: Its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab. Invest. 76(3), p365-374 (1997)
[ Specifity of the antibody clone N45.1.]
2) Y.Hattori, C.Nishigori, T.Tanaka, K.Uchida, O.Nikaido, T.Osawa, H.Hiai, S.Imamura, and S.Toyokuni: 8-Hydroxy-2'deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J. Invest. Dermatol. 107, p733-737 (1996)
[ Immunohistochemistry of UV-B irradiated mouse skin. ]
3) T.Tanaka, Y.Nishiyama, K.Okada, K.Hirota, M.Matsui, J.Yodoi, H.Hiai, and S.Toyokuni: Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion. Lab. Invest. 77(2), p145-155 (1997)
[ Immunohistochemistry of ferric nitrotriacetate-treated mouse kidney. ]
4) Y.Ihara, S.Toyokuni, K.Uchida, H.Odaka, T.Tanaka, H.Ikeda, H.Hiai, Y.Seino, and Y.Yamada: Hyperglycemia causes oxidative stress in pancreatic -cells of GK rats, a model of type 2 diabetes. Diabetes 48, p927-932 (1999)
[ Immunohistochemistry of pancreatic islets from GK rat, a diabetes model. ]
5) T. Ichiseki, A. Kaneuji, S. Katsuda1, Y. Ueda,T. Sugimori and T. Matsumoto: DNA oxidation injury in bone early after steroid administration is involved in the pathogenesis of steroid-induced osteonecrosis. Rheumatology 44,p456-460(2005)
[ Immunohistochemistry of rabbit tissue. ]
6) Lee YA, Cho EJ, Yokozawa T: Protective effect of persimmon (Diospyros kaki) peel proanthocyanidin against oxidative damage under H2O2 -induced cellular senescence. Biol Pharm Bull 31(6)p1265-1269(2008)
[ Application to human cultured cells. ]
Product name Code Content
Anti 8-OHdG monoclonal antibody MOG-020P 20 micro gram of IgG
MOG-100P 100 micro gram of IgG
 

 

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